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ROCEPHIN
Bacterial infections
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Drug Name:

ROCEPHIN Rx

Generic Name and Formulations:
Ceftriaxone sodium 500mg, 1g; IM or IV inj; sodium content 3.6mEq/g.

Company:
Roche Diagnostics Corp.

Therapeutic Use:

Indications for ROCEPHIN:

Susceptible bacterial septicemia, acute bacterial otitis media, lower respiratory tract, UTIs, skin and skin structure, bone and joint, pelvic inflammatory disease (PID), intraabdominal infections, meningitis, uncomplicated gonorrhea. Surgical prophylaxis.

Adult:

1–2g IM or IV once daily or in 2 equally divided doses; max 4g/day. Gonorrhea: 250mg IM once. Surgery: a single dose of 1g IV ½–2 hours pre-op.

Children:

50–75mg/kg per day in equally divided doses every 12hrs; max 2g/day. Skin and skin structures: may give once daily or in 2 equally divided doses every 12hrs; max 2g/day. Meningitis: 100mg/kg (max 4g) for 1 dose, then 100mg/kg per day (max 4g/day) once daily or in 2 equally divided doses every 12hrs for 7–14 days. Otitis media: 50mg/kg (max 1g) IM once.

Contraindications:

Hyperbilirubinemic or premature neonates. Concomitant calcium-containing IV solutions or products in neonates. Ceftriaxone solutions containing lidocaine for IV administration.

Warnings/Precautions:

Penicillin or other beta-lactam allergy. Discontinue if urolithiasis, oliguria, renal or gallbladder sonographic abnormalities, signs or symptoms occur. Renal failure: monitor; decrease dose if drug accumulation occurs. Chronic hepatic disease or malnutrition (impaired Vit. K synthesis or storage): monitor prothrombin time. Both hepatic and significant renal impairment: usual max 2g/day. GI disease (esp. colitis). Ensure adequate hydration. Pregnancy (Cat.B). Nursing mothers.

Interactions:

See Contraindications. Increase risk of bleeding with concomitant Vit. K antagonists. May be potentiated by probenecid. Precipitation can form with calcium-containing solutions; avoid. May cause false (+) Clinitest or Coomb's test.

Pharmacological Class:

Cephalosporin.

Adverse Reactions:

Local reactions, hematologic effects (eg, eosinophilia), rash, diarrhea, elevated liver enzymes; rare: hemolytic anemia, allergic pneumonitis, seizures, anaphylaxis, pancreatitis.

How Supplied:

Vials—1, 10

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