Risk Assessment

Recurrence Score Appears To Be Driving Personalized Treatment for Breast Cancer

Recurrence Score Appears To Be Driving Personalized Treatment for Breast Cancer

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The recurrence score assay stratifies early stage, estrogen receptor-positive breast cancer by recurrence risk. This study assessed how clinicians use the recurrence score to recommend adjuvant systemic therapy or patients' experiences with testing decision-making.

Socioeconomic Status Inversely Related to Risk for Ovarian Cancer in African American Women

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Risk of ovarian cancer is higher in African American women with lower socioeconomic status, the opposite of trends seen in breast cancer.

Prophylactic Gynecologic Resections Increase Risk for Aggressive Uterine Cancer in BRCA Gene Mutation Carriers

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Women who carry the BRCA1 mutation are at increased risk for serous/serous-like endometrial carcinoma after risk-reducing salpingo-oophorectomy. Yet uncertainty exists over the need to perform a full hysterectomy in these women.

Sleep Disorders in Cancer Radiation Therapy: Little Understood, Often Undetected — and Important

Sleep Disorders in Cancer Radiation Therapy: Little Understood, Often Undetected — and Important

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Sleep patterns and habits should be a part of oncology nurses' routine patient assessment, as sleep disorders can be a significant challenge for cancer patients undergoing radiation therapy.

Baseline PSA Levels in Midlife Could Predict Risk of Lethal Prostate Cancer

Baseline PSA Levels in Midlife Could Predict Risk of Lethal Prostate Cancer

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Screening PSA levels at midlife could identify men who are at greater risk of developing prostate cancer later in life and who should be monitored more closely.

Biochemical Marker Is a Better Predictor of Adverse Effects in Patients with Non-small Cell Lung Cancer

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Albumin concentration with an established cutoff point is proven a better predictor of both chemotherapy toxicity and survival in patients with advanced lung cancer.

Prognostic Index Will Improve Clinical Practice Management of Patients With CLL and in Clinical Trials

Prognostic Index Will Improve Clinical Practice Management of Patients With CLL and in Clinical Trials

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An international consortium devised an international prognostic index for chronic lymphocytic leukemia (CLL-IPI) that combines genetic, biochemical, and clinical parameters into a prognostic model to enable more targeted management of patients with CLL.

Rates of Colorectal Cancer Are Increasing in Younger Patients, Despite an Overall Decline

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Reasons for the continuing increase in cases of young-onset colorectal cancer, despite a decline in the overall rate of the disease in recent years, are unclear.

Study Finds Racial Disparities in Breast and Ovarian Cancer Risk Management

Study Finds Racial Disparities in Breast and Ovarian Cancer Risk Management

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Disparities in cancer risk management among BRCA carriers across a diverse sample of young black, Hispanic, and non-Hispanic white breast cancer survivors underscores that "the benefit from genetic testing comes from acting on the test results," not just the testing itself, a study presented at the ASCO 2016 Annual Meeting concluded.

Participants Understand Implications of Multiplex Gene Testing for Inherited Cancer Risk

Participants Understand Implications of Multiplex Gene Testing for Inherited Cancer Risk

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Multiplex gene testing of diverse patients has found that patients who test positive advise relatives to test, "suggesting that participants understood the implications of test results," according to results of a planned interim analysis of a prospective trial presented at the ASCO 2016 Annual Meeting.

New Research Questions Recommendations Regarding PSA Tests for Prostate Cancer Screening

New Research Questions Recommendations Regarding PSA Tests for Prostate Cancer Screening

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New research results favor testing for prostate specific antigen (PSA) levels for detection of prostate cancer. PSA tests can reduce the number of fatal cases of prostate cancer by detecting disease early.

Moderate Link for Automated and Clinical Breast Density Measures

Moderate Link for Automated and Clinical Breast Density Measures

Both automated and clinical assessments of breast density are associated with breast cancer risk.

Recent Cancer Diagnoses May Coincide With Mental Health Comorbidities

Recent Cancer Diagnoses May Coincide With Mental Health Comorbidities

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Having a recent cancer diagnosis is associated with an increased risk for some mental health disorders and increased use of psychiatric medications.

More Than HPV Vaccine Uptake Is Needed to Reduce the Burden of HPV-associated Cancers

More Than HPV Vaccine Uptake Is Needed to Reduce the Burden of HPV-associated Cancers

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Although HPV vaccination is expected to decrease the cancer burden from HPV across all racial and ethnic groups, some disparities are expected to persist and widen if their causes are not addressed, including lack of access to screening, timely diagnoses, and treatment.

German Study Confirms Accuracy of Multigene Test Predictions of Safe Omission of Chemotherapy for Breast Cancer

German Study Confirms Accuracy of Multigene Test Predictions of Safe Omission of Chemotherapy for Breast Cancer

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A multigene test can identify patients with early stage breast cancer who do not need chemotherapy and who will be alive 5 years after diagnosis.

Risk Stratification and Treatment Options Differ for Male and Female Patients With Breast Cancer

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Optimal risk stratification differs between male and female breast cancers. Outcomes for male patients with breast cancer were not significantly correlated with histologic grade, unlike for female patients.

High-risk HPV Infection Increases Risk for Anal Cancer

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Anal cancer is associated with human papillomavirus (HPV) infection, and some women are at increased likelihood of have both diseases.

Familial Risk and Heritability of Cancer Is Higher Among Twins

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Twins carry a significant excess familial risk for cancer overall and for specific types of cancer, including prostate, melanoma, breast, ovary, and uterus, according to a long-term follow-up study of twins in Nordic countries.

Risk for Colorectal Cancer Varies Among Latino Subgroups

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Researchers found that colorectal cancer risk in Californian Latinos vary widely based on their country of origin.

Repeating PSA Test in Select Patients Can Mitigate Controversial Issues in Prostate Cancer Screening

Repeating PSA Test in Select Patients Can Mitigate Controversial Issues in Prostate Cancer Screening

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Some task forces advocate abandoning the use of the screening PSA test because it leads to unnecessary prostate biopsies. Canadian researchers show that repeating the test in select patients can reduce the number of biopsies.

Model Uses Nonclinical Calculations to Forecast the Metastasis Path of Breast Cancer

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Researchers developed a mathematical model to forecast metastatic breast cancer survival rates using techniques usually reserved for weather prediction, financial forecasting, and surfing the Web.

New Model for Breast Cancer Risk in Hispanic Women Is the First to be Based Exclusively on Data From Hispanic Women

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The first breast cancer risk-prediction model based entirely on data from Hispanic women, including whether a woman was born in or outside the United States, provides a more accurate assessment of Hispanic women's risk of developing breast cancer.

Precision Medicine Trial in Cancer Prevention Identifies Chemoprevention Strategy

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A team of scientists has reported that the genetic biomarker LOH is able to predict which patients with premalignant mouth lesions are at highest risk of developing oral cancer. The findings present a new tool that could be used to identify patients most likely to benefit from chemoprevention.

Study Uses Elephants and Other Mammals to Explore Potential Mechanisms of Cancer Resistance

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Multiple copies of a cancer-suppression gene may play a role in why elephants have a lower-than-expected rate of cancer, findings that have the potential to provide a better understanding of the mechanisms related to cancer suppression, including in humans.

Social Deprivation and Gender Impact Incidence of Hodgkin Lymphoma

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Living in overcrowded conditions appears to protect children and young adults against developing a subtype of Hodgkin lymphoma. The protective effect suggests that infections earlier in life may stimulate the immune system to deal with future infections and cancerous cells more efficiently.

Genetic test helps identify risk for more aggressive disease, improving myeloma treatment

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New research has identified as few as nine genetic features would need to be tested to identify high-risk patients who might benefit from intensive myeloma treatment.

Clinical scoring system suggests more precise colon cancer screening is possible

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A clinical scoring system for colon cancer risk could help physicians determine which patients require colonoscopies and which could be adequately screened using less invasive methods.

Multigene panel tests may identify less common harmful mutations in moderate-risk genes

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Multigene testing of women negative for BRCA1 and BRCA2 uncovered other harmful genetic mutations.

Novel algorithm identified DNA copy-number landscapes in African Americans with colon cancer

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An algorithm dubbed ENVE can help clinicians sort through "white noise" and pinpoint genetic aberrations associated with cancer.

Obesity associated with increased breast cancer risk in postmenopausal women

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Clinical trial data suggests that postmenopausal women of above-average weight have an increased risk of breast cancer.

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