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RIFADIN IV INJECTION
Bacterial infections
Tuberculosis
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Drug Name:

RIFADIN IV INJECTION Rx

Generic Name and Formulations:
Rifampin 600mg/vial; pwd for IV inf after reconstitution.

Company:
Sanofi Aventis

Therapeutic Use:

Indications for RIFADIN IV INJECTION:

Asymptomatic carriers of Neisseria meningitidis to eliminate meningococci from nasopharynx.

Adult:

600mg twice daily for 2 days. Oral: give 1 hour before or 2 hours after meals with water.

Children:

<1 month: 5mg/kg every 12 hours for 2 days. ≥1 month: 10mg/kg every 12 hours for 2 days; max 600mg per dose. Oral: give 1 hour before or 2 hours after meals with water. Preparation of suspension: see full labeling.

Contraindications:

Concomitant ritonavir-boosted saquinavir (increased risk of severe hepatotoxicity). Concomitant atazanavir, darunavir, fosamprenavir, saquinavir, tipranavir. Rifamycin hypersensitivity.

Warnings/Precautions:

Reserve drug for cases where high risk of meningococcal meningitis exists. Confirm diagnosis. Not recommended for intermittent therapy (risk of renal hypersensitivity reactions; rare). Monitor for hypersensitivity reactions (eg, DRESS); discontinue if occur. Impaired hepatic function; monitor LFTs at baseline and then every 2–4 weeks. Diabetes. May stain body secretions and contact lenses. IV: avoid extravasation. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

See Contraindications. Reduces serum levels of protease inhibitors: avoid concomitant use. Antagonizes anticonvulsants, digitoxin, antiarrhythmics, oral anticoagulants, antifungals, barbiturates, β-blockers, calcium channel blockers, chloramphenicol, clarithromycin, corticosteroids, cyclosporine, cardiac glycosides, clofibrate, oral or other hormonal contraceptives (consider nonhormonal methods), dapsone, diazepam, doxycycline, fluoroquinolones, haloperidol, oral hypoglycemics, levothyroxine, methadone, narcotic analgesics, progestins, quinine, tacrolimus, theophylline, tricyclic antidepressants, zidovudine, atovaquone, enalapril, sulfasalazine. May be potentiated by atovaquone, probenecid, cotrimoxazole. Concomitant ketoconazole decreases serum concentration of both drugs. Monitor prothrombin time with concomitant anticoagulants. Separate dosing of antacids by at least 1 hour. Avoid concomitant halothane. May cause false (+) urine tests for opiates. May inhibit assays for serum folate and Vit. B12 (consider alternative methods). Perform LFTs and use contrast media prior to morning dose.

See Also:

RIFADIN

Pharmacological Class:

Rifamycin.

Adverse Reactions:

GI disturbances, jaundice, headache, fever, drowsiness, fatigue, ataxia, dizziness, inability to concentrate, mental confusion, muscular weakness, pain in extremities, generalized numbness, visual disturbances, elevated BUN and serum uric acid, menstrual disturbances, urticaria, rash; rare: hepatitis, abnormal LFTs, blood dyscrasias, DRESS (may be fatal).

How Supplied:

150mg—30; 300mg—60, 100; Vials—1

Indications for RIFADIN IV INJECTION:

Susceptible pulmonary tuberculosis.

Adult:

10mg/kg in a single dose; max 600mg/day. Oral: give 1 hr before or 2 hrs after meals with water.

Children:

10–20mg/kg; max 600mg/day. Oral give 1 hr before or 2 hrs after meals with water. Preparation of suspension: see full labeling.

Contraindications:

Concomitant ritonavir-boosted saquinavir (increased risk of severe hepatotoxicity). Concomitant atazanavir, darunavir, fosamprenavir, saquinavir, tipranavir. Rifamycin hypersensitivity.

Warnings/Precautions:

Use with other antituberculars. Not recommended for intermittent therapy (risk of renal hypersensitivity reactions; rare). Impaired hepatic function. Obtain baseline LFTs (then every 2–4 weeks), bilirubin, serum creatinine, CBC, platelets. Diabetes. May stain body secretions and contact lenses. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

See Contraindications. Reduces serum levels of protease inhibitors: avoid concomitant use. Antagonizes anticonvulsants, digitoxin, antiarrhythmics, oral anticoagulants, antifungals, barbiturates, β-blockers, calcium channel blockers, chloramphenicol, clarithromycin, corticosteroids, cyclosporine, cardiac glycosides, clofibrate, oral or other hormonal contraceptives (consider nonhormonal methods), dapsone, diazepam, doxycycline, fluoroquinolones, haloperidol, oral hypoglycemics, levothyroxine, methadone, narcotic analgesics, progestins, quinine, tacrolimus, theophylline, tricyclic antidepressants, zidovudine, atovaquone, enalapril, sulfasalazine. May be potentiated by atovaquone, probenecid, cotrimoxazole. Concomitant ketoconazole decreases serum concentration of both drugs. Monitor prothrombin time with concomitant anticoagulants. Separate dosing of antacids by at least 1 hour. Avoid concomitant halothane. May cause false (+) urine tests for opiates. May inhibit assays for serum folate and Vit. B12 (consider alternative methods). Perform LFTs and use contrast media prior to morning dose.

See Also:

RIFADIN

Pharmacological Class:

Rifamycin.

Adverse Reactions:

GI disturbances, jaundice, headache, fever, drowsiness, fatigue, ataxia, dizziness, inability to concentrate, mental confusion, muscular weakness, pain in extremities, generalized numbness, visual disturbances, elevated BUN and serum uric acid, menstrual disturbances, urticaria, rash; rare: hepatitis, abnormal LFTs, blood dyscrasias, DRESS (may be fatal).

How Supplied:

150mg—30; 300mg—60, 100; Vials—1

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