Research

Multiscale Modeling Framework Predicts Tumor Growth

Multiscale Modeling Framework Predicts Tumor Growth

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Researchers from 3 Texas institutions collaborated on a multiscale framework for modeling tumor growth, with potential to inform growth patterns and tumor density.

Manipulation Increases Susceptibility of Triple-Negative Breast Cancer to Conventional Therapy

Manipulation Increases Susceptibility of Triple-Negative Breast Cancer to Conventional Therapy

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Researchers manipulated triple-negative breast cancer cells to make them susceptible to conventional antiestrogen therapy for breast cancer.

Thyroid Cancer Incidence Increasing Among Younger, Hispanic, African American Populations

Thyroid Cancer Incidence Increasing Among Younger, Hispanic, African American Populations

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A report on incidence of thyroid cancer shows incidence of the disease is increasing among certain populations: younger persons, Hispanic, and African American.

JAK1, JAK2 Inhibition Improves Outcomes in Myeloproliferative Neoplasms, But More Is Needed

JAK1, JAK2 Inhibition Improves Outcomes in Myeloproliferative Neoplasms, But More Is Needed

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Myelofibrosis, extensive splenomegaly, and symptomatic burden are significantly improved for patients with MPN by JAK1 and JAK2 inhibition; however, some major needs in this patient group are still largely unmet.

Analysis & Perspective on Practical and Ethical Use and Interpretation of Whole Genome Sequencing Data During Clinical Trials

Analysis & Perspective on Practical and Ethical Use and Interpretation of Whole Genome Sequencing Data During Clinical Trials

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Despite the value of genomic sequence information, nurses need to be aware of the limitations of this information and ethical concerns regarding sharing it with patients.

Mastectomy Skin Flap Necrosis: Challenges and Solutions

Mastectomy Skin Flap Necrosis: Challenges and Solutions

[Breast Cancer: Targets and Therapy] This research discusses the management options for incidents of mastectomy skin flap necrosis (MSFN).

Research Shows iPS-ML/IFN-β Migrates to, Penetrate Liver Cancer Tumors

Research Shows iPS-ML/IFN-β Migrates to, Penetrate Liver Cancer Tumors

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Decreased liver tumor growth and improved survival in a mouse model were noted after injecting iPS-ML/IFN-β.

A Single Institution Report of 19 Hepatocellular Carcinoma Patients With Bile Duct Tumor Thrombus

A Single Institution Report of 19 Hepatocellular Carcinoma Patients With Bile Duct Tumor Thrombus

[Journal of Hepatocellular Carcinoma] This research examines the outcomes of HCC patients with BDTT in a single institution.

Barriers in Routine Care Coverage for Cancer Clinical Trial Participants Still Exist

Barriers in Routine Care Coverage for Cancer Clinical Trial Participants Still Exist

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Despite the ACA mandate on coverage for clinical trial participants, many facilities involved in cancer research still coping with insurance denials for participants.

Serum Liver Enzymes Serve as Prognostic Factors in Patients With Intrahepatic Cholangiocarcinoma

Serum Liver Enzymes Serve as Prognostic Factors in Patients With Intrahepatic Cholangiocarcinoma

This study examines the influences of liver enzymes on the overall survival in a number of patients with intrahepatic cholangiocarcinoma (ICC).

Arm Lymphoscintigraphy After Axillary Lymph Node Dissection or Sentinel Lymph Node Biopsy in Breast Cancer

Arm Lymphoscintigraphy After Axillary Lymph Node Dissection or Sentinel Lymph Node Biopsy in Breast Cancer

[OncoTargets and Therapy] This research examines the lymphatic flow in the arm following breast cancer surgery and axillary lymph node dissection (ALND) versus sentinel lymph node biopsy (SLNB) using lymphoscintigraphy (LS).

NCI Funds Project to Investigate Cancer Progression, Survival in African Americans

NCI Funds Project to Investigate Cancer Progression, Survival in African Americans

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NCI awarded a $9 million grant to Barbara A. Karmanos Cancer Institute and Wayne State University to explore factors contributing to racial disparities in cancer.

Immunosuppressor Inhibits Metabolic Pathway in Breast Cancer, Kills Cancer Cells

Immunosuppressor Inhibits Metabolic Pathway in Breast Cancer, Kills Cancer Cells

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Leflunomide, an immunosuppressor FDA-approved for rheumatoid arthritis, is effective against breast cancer in mouse study.

Research Shows Vitamin B3 Reduces Pain From Chemotherapy-Induced Peripheral Neuropathy

Research Shows Vitamin B3 Reduces Pain From Chemotherapy-Induced Peripheral Neuropathy

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Nicotinamide riboside, a type of B3 vitamin, was shown to prevent chemotherapy-induced peripheral neuropathy in an animal-model study.

Docetaxel-associated Myalgia-arthralgia Syndrome in Patients With Breast Cancer

Docetaxel-associated Myalgia-arthralgia Syndrome in Patients With Breast Cancer

[Breast Cancer: Targets and Therapy] This research examines possible risk factors and effectiveness of treatments for docetaxel-associated myalgia-arthralgia syndrome.

Pediatric Hepatocellular Carcinoma: Challenges and Solutions

Pediatric Hepatocellular Carcinoma: Challenges and Solutions

[Journal of Hepatocellular Carcinoma] This research examines the medical challenges presented by pediatric hepatocellular carcinoma (HCC).

Myalgia-arthralgia Syndrome Associated With Taxanes in Patients with Breast Cancer

Myalgia-arthralgia Syndrome Associated With Taxanes in Patients with Breast Cancer

[Breast Cancer: Targets and Therapy] This research examines predisposing factors, prevention, and therapy of myalgia-arthralgia syndrome (M-AS).

Clinical Trial Enrollment of Adolescent and Young Adult Patients With Cancer: A Systematic Review of the Literature and Proposed Solutions

Clinical Trial Enrollment of Adolescent and Young Adult Patients With Cancer: A Systematic Review of the Literature and Proposed Solutions

[Clinical Oncology in Adolescents and Young Adults] This research evaluates methods that have been utilized in the clinical trial enrollment for adolescent and young adults with cancer.

Inflammatory Cytokine Levels Increase Breast Tissue Density, Cancer Risk

Inflammatory Cytokine Levels Increase Breast Tissue Density, Cancer Risk

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Discovered link between inflammation and overexpression of CCL2 hints at potential of anti-inflammatory medications as a breast cancer preventive in women with dense-tissue breasts.

Gastric and Colon Metastasis From Breast Cancer: Case Report, Review of the Literature, and Possible Underlying Mechanisms

Gastric and Colon Metastasis From Breast Cancer: Case Report, Review of the Literature, and Possible Underlying Mechanisms

[Breast Cancer: Targets and Therapy] This research presents a case report of patient with gastrointestinal metastases from breast cancer.

Pediatric Papillary Thyroid Cancer: Current Management Challenges

Pediatric Papillary Thyroid Cancer: Current Management Challenges

[OncoTargets and Therapy] This research presents an overview of patient and disease management in pediatric pediatric papillary thyroid (PTC) patients.

New Understanding of Mechanisms Revealed in Development of Breast Cancer and Resistance to Treatment

New Understanding of Mechanisms Revealed in Development of Breast Cancer and Resistance to Treatment

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Researchers explore the biologic influences of breast cancer development and resistance to treatment.

Recombinant human endostatin in combination with CHOP regimen for peripheral T cell lymphoma

Recombinant human endostatin in combination with CHOP regimen for peripheral T cell lymphoma

[OncoTargets and Therapy] This research examines the efficacy and safety of recombinant human endostatin in combination with CHOP regimen (ECHOP) for patients with peripheral T cell lymphoma.

Omega-3 Polyunsaturated Fatty Acids in the Prevention of Postoperative Complications in Colorectal Cancer: A Meta-analysis

Omega-3 Polyunsaturated Fatty Acids in the Prevention of Postoperative Complications in Colorectal Cancer: A Meta-analysis

[OncoTargets and Therapy] This research evaluates the clinical efficacy of omega-3 PUFAs in the prevention of postoperative complications in colorectal cancer patients.

What You Do Not Know Could Hurt You: What Women Wish Their Doctors Had Told Them About Chemotherapy Side Effects on Memory and Response to Alcohol

What You Do Not Know Could Hurt You: What Women Wish Their Doctors Had Told Them About Chemotherapy Side Effects on Memory and Response to Alcohol

[Breast Cancer: Basic and Clinical Research] This research examines the incidence of alcohol and memory-related side effects of chemotherapy in female cancer patients.

Comparison of Three Information Sources for Smoking Information in Electronic Health Records

Comparison of Three Information Sources for Smoking Information in Electronic Health Records

[Cancer Informatics] This research examinbed independent and joint performance of retrieving smoking status through different sources and compared the performance of retrieving smoking strength information from narrative text and PPI.

The evolution of the diminishing role of extrapleural pneumonectomy in the surgical management of malignant pleural mesothelioma

The evolution of the diminishing role of extrapleural pneumonectomy in the surgical management of malignant pleural mesothelioma

[OncoTargets and Therapy] The surgical approach that offers the best outcomes for malignant pleural mesothelioma management is still debated. This research examines the efficacy of surgical treatment.

Comparing Popular Commercial Cancer Gene Tests Yield Different Results

Comparing Popular Commercial Cancer Gene Tests Yield Different Results

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A head-to-head comparison of two commercial gene sequencing tests yielded differing results.

Management of Hypoglycemia in Nondiabetic Palliative Care Patients: A Prognosis-Based Approach

Management of Hypoglycemia in Nondiabetic Palliative Care Patients: A Prognosis-Based Approach

[Palliative Care: Research and Treatment] This research discusses the epidemiology, evidence-based recommendations, etiology, and mechanisms of hypoglycemia, as well as its management in hospice care or inpatient palliative care wards.

Profile of Tivantinib and its Potential in the Treatment of Hepatocellular Carcinoma: The Evidence to Date

Profile of Tivantinib and its Potential in the Treatment of Hepatocellular Carcinoma: The Evidence to Date

[Journal of Hepatocellular Carcinoma] This research examines tivantinib and its therapeutic profile in the management of hepatocellular carcinoma.

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