Andrographolide Potentiates the Antitumor Effect of Topotecan in Acute Myeloid Leukemia Cells Through an Intrinsic Apoptotic PathwayJune 15, 2018
[Cancer Management and Research] In this study, researchers explored the potential of andrographolide and topotecan, separately and together, in the in vitro treatment of the U937 acute myeloid leukemic cell line.
[OncoTargets and Therapy] In a review of cancer stem cells (CSCs)/ovarian cancer stem cells (OCSCs), researchers discuss the implications of immunotherapy development based on studying cancer evolution by CSCs, and targeting OCSC surface markers to develop CAR-T immunotherapy.
This fact sheet reviews cancer in adolescents and children, including possible causes, treatment, and the general outlook for childhood cancers.
Response to Rapamycin Analogs but not PD-1 Inhibitors in PTEN-mutated Metastatic Non-small Cell Lung Cancer With High Tumor Mutational BurdenJune 01, 2018
[Lung Cancer: Targets and Therapy] This case study demonstrates that genomic profiling may still benefit patients who fail checkpoint inhibitor therapy despite having high tumor mutational burden and PD-L1 positivity.
Multiple Treatment Modalities for Brain Metastasis in Patients With EGFR-mutant Non-small Cell Lung CancerMay 25, 2018
[OncoTargets and Therapy] Management of brain metastases in patients with EGFR-mutant NSCLC is controversial. In this study, researchers find combination and sequential treatment with EGFR-TKIs, chemotherapy, and radiotherapy is beneficial.
[Lung Cancer: Targets and Therapy] Italian researchers report on the role of GLI1 in the development of lung cancer, and review its potential as an effective therapy for lung cancer.
[Cancer Management and Research] A review of marginal zone lymphomas, a common and varied group of hematologic malignancies, and their treatment, with a focus on the Bruton's tyrosine kinase ibrutinib.
[Gastrointestinal Cancer: Targets and Therapy] This review presents the most up-to-date molecular, clinical, and therapeutic data, including an overview of a current phase 3 study assessing the efficacy of simultaneous BRAF, EGFR, and MEK inhibition among patients with BRAFV600E-mutant CRC.
Clinicopathological Features and Prognosis in Elderly Gastric Cancer Patients: A Retrospective Cohort StudyApril 27, 2018
[OncoTargets and Therapy] A retrospective study assessed patients with gastric cancer, identifying disease characteristics more prevalent in elderly patients and the effect on prognosis for these patients.
[Breast Cancer: Targets and Therapy] Researchers present a review of the LHRH agonist triptorelin and the use of this agent to induce chemical castration in estrogen-sensitive breast cancer tumors in younger women.
Bax, Bcl-2, and Bax/Bcl-2 as Prognostic Markers in Acute Myeloid Leukemia: Are We Ready for Bcl-2-Directed Therapy?April 13, 2018
[Cancer Management and Research] This report presents an assessment of the relationship of Bax/Bcl-2 expression and the clinical response of patients with AML treated with cytarabine plus daunorubicin, and their potential as biomarkers to predict chemotherapeutic outcomes.
[Gastrointestinal Cancer: Targets and Therapy] This review discusses novel tools and newer technologies that have been employed to address iCCA.
[Breast Cancer: Targets and Therapy] In this retrospective analysis of medical records and estimated costs of treatment, investigators demonstrated that rapid change based on level I evidence is feasible.
How is clinical trial eligibility determined?
[OncoTargets and Therapy] A meta-analysis was conducted to evaluate the effect of abnormal EGFR expression on overall survival (OS) in patients with glioma.
[Journal of Gastrointestinal Oncology] A review of diagnostic parameters and management modalities for checkpoint inhibitor-induced hepatic toxicity is presented.
[OncoTargets and Therapy] This review examines the rationale of olaratumab in the treatment of advanced soft-tissue sarcomas and its emerging role in clinical practice.
[Cancer Management and Research] The presence of comorbidities is thought to play a significant role in the decision to treat patients with NSCLC, and this impacts survival.
[Breast Cancer: Targets and Therapy] A review of studies investigating the efficacy of buparlisib monotherapy and in combination with various other anticancer agents in the treatment of breast cancer and other solid tumors.
A review of management approaches to Hodgkin lymphoma in Europe vs the United States/North America demonstrates that although some differences exist, worldwide studies that would enhance patient outcomes are feasible.
Efficacy and Safety of COX-2 Inhibitors for Advanced Non-small-cell Lung Cancer With Chemotherapy: A Meta-analysisFebruary 16, 2018
[OncoTargets and Therapy] This meta-analysis assesses the efficacy and safety profile of COX-2 inhibitors in patients with advanced non-small-cell lung cancer.
[Cancer Management and Research] A review of vulvar carcinoma and treatment options for patients with rare gynecologic cancer.
Comparative Study of Clinical Efficacy Using Three-dimensional and Two-dimensional Laparoscopies in the Treatment of Distal Gastric CancerFebruary 02, 2018
[OncoTargets and Therapy] This study investigated the safety and feasibility of 3D laparoscopic-assisted radical gastrectomy for distal advanced gastric cancer vs 2D laparoscopic surgery, results of this study have shown.
[Cancer Management and Research] Radiation dose, fractionation strategies, and predictive factors of response to therapy in patients with esophageal carcinoma are reviewed to determine if more intense local therapy would lead to better outcomes and for which patients.
1. The β-chain constant region of the T cell receptor (TCR) was targeted to specifically eliminate a population of malignant T cells. 2. Engineered chimeric antigen receptor (CAR) T cells with specificity to the β-chain constant region successfully eradicated a significant proportion of malignant T cells in mice. Evidence Rating Level: 3 (Average) Study Rundown: 
Feasibility and Outcomes of Modified Enhanced Recovery After Surgery for Nursing Management of Aged Patients Undergoing EsophagectomyJanuary 19, 2018
[Journal of Thoracic Disease] A randomized study investigated whether an mERAS protocol could result in improved recovery of aged patients with esophageal cancer undergoing esophagectomy.
Comparison of Survival Outcomes Between Radical Hysterectomy and Definitive Radiochemotherapy in Stage IB1 and IIA1 Cervical CancerJanuary 12, 2018
[Cancer Management and Research] A comparison study evaluated whether radical hysterectomy or radiochemotherapy provides superior survival outcomes for patients with stage IB1 or IIA1 cervical cancer.
[Breast Cancer: Targets and Therapy] Researchers present a review of study findings on the effect of statins on clinical outcomes for patients with breast cancer.
In an effort to find alternatives to cisplatin as a radiation sensitizer, due to its dose-dependent toxicity and resistance, researchers are exploring food-based options such as blueberry extract.
Investigators sought to determine why so few biospecimens were available for research from minority populations of women with breast cancer.
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