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REQUIP
Parkinsonism
Restless legs syndrome
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Drug Name:

REQUIP Rx

Generic Name and Formulations:
Ropinirole (as HCl) 0.25mg, 0.5mg, 1mg, 2mg, 3mg, 4mg, 5mg; tabs.

Company:
GlaxoSmithKline

Therapeutic Use:

Indications for REQUIP:

Parkinson's disease.

Adult:

Initially 0.25mg 3 times daily, then increase by 0.25mg 3 times daily at 1-week intervals to 1mg 3 times daily to 4th week. May increase by 1.5mg/day at 1-week intervals up to 9mg/day, then by up to 3mg/day at 1-week intervals to max 24mg/day. ESRD on dialysis: initially 0.25mg 3 times daily; max 18mg/day. Withdraw gradually over 7 days.

Children:

Not established.

Warnings/Precautions:

See full labeling. Consider discontinuing if excessive daytime sleepiness or if sudden onset of sleep during daily activities occurs. Monitor for drowsiness or sleepiness, and for orthostatic hypotension. Dyskinesia. Sleep disorders. Severe renal or hepatic impairment. Significant cardiovascular disease; monitor for hypertension and changes in heart rate. Psychotic disorders. Urges/compulsive behaviors. Monitor for melanoma; perform periodic skin exams. Fibrotic complications. Avoid abrupt cessation. Elderly. Pregnancy. Nursing mothers.

Interactions:

May potentiate dopaminergic effects (eg, dyskinesia) with levodopa; consider reducing dose of levodopa. Additive CNS effects when concomitant alcohol, other CNS depressants (eg, benzodiazepines, antipsychotics, antidepressants). May be potentiated by CYP1A2 inhibitors (eg, ciprofloxacin). May be antagonized by CYP1A2 inducers (eg, cigarette smoking) or dopamine antagonists (eg, phenothiazines, butyrophenones, metoclopramide). Adjust ropinirole dose if estrogens are added or discontinued.

See Also:

REQUIP XL

Pharmacological Class:

Dopamine agonist (non-ergot).

Adverse Reactions:

Early parkinsonism (without levodopa): nausea, somnolence (including sudden sleep onset), dizziness, syncope, asthenia, infection, edema, vomiting, dyspepsia, hypertension, headache, abdominal pain/discomfort, constipation. Advanced disease (with levodopa): also dyskinesia, confusion, hallucinations (esp. in elderly), sweating. Both: withdrawal-emergent hyperpyrexia and confusion.

How Supplied:

Tabs—100; XL tabs—30

Indications for REQUIP:

Restless legs syndrome.

Adult:

Titrate gradually. Take once-daily 1–3 hrs before bedtime. Initially 0.25mg on Days 1 & 2, then 0.5mg on Days 3–7, increase by 0.5mg/day at 1-week intervals to 3mg then may increase to 4mg after 1 week; max 4mg/day. ESRD on dialysis: initially 0.25mg once daily; max 3mg/day. Withdraw gradually.

Children:

Not established.

Warnings/Precautions:

See full labeling. Consider discontinuing if excessive daytime sleepiness or if sudden onset of sleep during daily activities occurs. Monitor for drowsiness or sleepiness, and for orthostatic hypotension. Dyskinesia. Sleep disorders. Severe renal or hepatic impairment. Significant cardiovascular disease; monitor for hypertension and changes in heart rate. Psychotic disorders. Urges/compulsive behaviors. Monitor for melanoma; perform periodic skin exams. Fibrotic complications. Avoid abrupt cessation. Elderly. Pregnancy. Nursing mothers.

Interactions:

Additive CNS effects when concomitant alcohol, other CNS depressants (eg, benzodiazepines, antipsychotics, antidepressants). Potentiated by ciprofloxacin, possibly other CYP1A2 inhibitors. May be antagonized by dopamine antagonists (eg, phenothiazines, butyrophenones, metoclopramide). Adjust ropinirole dose if estrogens are added or discontinued. Monitor with drugs that induce CYP1A2 (eg, cigarette smoke).

Pharmacological Class:

Dopamine agonist (non-ergot).

Adverse Reactions:

Nausea, vomiting, somnolence, dizziness, fatigue, asthenia, malaise; hallucinations, dyskinesia, withdrawal-emergent hyperpyrexia and confusion, augmentation and early-morning rebound.

How Supplied:

Tabs—100

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