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REPATHA PUSHTRONEX
Hyperlipoproteinemias
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Drug Name:

REPATHA PUSHTRONEX Rx

Generic Name and Formulations:
Evolocumab 420mg/3.5mL; per system (on-body infusor with prefilled cartridge); soln for SC use; preservative-free.

Company:
Amgen, Inc.

Therapeutic Use:

Indications for REPATHA PUSHTRONEX:

Adjunct to diet and maximally tolerated statin therapy, in adults with heterozygous familial hypercholesterolemia (HeFH) or clinical atherosclerotic cardiovascular disease requiring additional lowering of LDL-C. Adjunct to diet and other LDL-lowering therapies, in patients with homozygous familial hypercholesterolemia (HoFH) requiring additional lowering of LDL-C.

Limitations Of use:

Effect on cardiovascular morbidity and mortality has not been determined.

Adult:

Give by SC inj into abdomen, thigh, or upper arm; rotate inj sites. HeFH or primary hyperlipidemia: 140mg every 2 weeks or 420mg once monthly. HoFH: (≥13yrs): 420mg once monthly; measure LDL-C levels 4–8 weeks after initiation. To administer 420mg dose: give over 9 mins by using the on-body infusor or as 3 inj consecutively within 30 mins using the prefilled syringe or autoinjector.

Children:

HeFH or primary hyperlipidemia: not established. HoFH: <13yrs: not established.

Warnings/Precautions:

Do not inject into areas that are tender, bruised, red, or indurated. Discontinue if serious allergic reactions occur. Severe renal or hepatic impairment. Pregnancy. Nursing mothers.

Interactions:

Avoid co-administration with other injectable drugs at same inj site.

See Also:

REPATHA

Pharmacological Class:

Proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitor.

Adverse Reactions:

Nasopharyngitis, URTI, influenza, back pain, inj site reactions.

Generic Availability:

NO

How Supplied:

Single-use prefilled syringe—1; Single-use prefilled SureClick autoinjector—1, 2, 3; Single-use Pushtronex system—1

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