Renal Cell Carcinoma

Alternating Pazopanib and Everolimus Treatment Schedule Not Effective for RCC

Alternating Pazopanib and Everolimus Treatment Schedule Not Effective for RCC

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Alternating treatment with pazopanib and everolimus failed to prolong progression-free survival compared with continuous pazopanib.

Prognostic role of pretreatment serum albumin in renal cell carcinoma: a systematic review and meta-analysis

Prognostic role of pretreatment serum albumin in renal cell carcinoma: a systematic review and meta-analysis

[OncoTargets and Therapy] This research examines the prognostic value of pretreatment serum albumin in RCC patients.

Adjuvant Girentuximab Not Effective for Renal Cell Carcinoma

Adjuvant Girentuximab Not Effective for Renal Cell Carcinoma

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Phase 2 studies have demonstrated that girentuximab possesses activity with a manageable safety profile for patients with clear cell renal cell carcinoma; therefore, in a phase 3 trial, researchers evaluated its efficacy and safety as adjuvant monotherapy.

Clinical Use of Cabozantinib in the Treatment of Advanced Kidney Cancer: Efficacy, Safety, and Patient Selection

Clinical Use of Cabozantinib in the Treatment of Advanced Kidney Cancer: Efficacy, Safety, and Patient Selection

[OncoTargets and Therapy] This research We reviews the development of cabozantinib in advanced renal cell carcinoma and its role in the treatment landscape.

New Class of Drugs Shows Promise Against Kidney Cancer

New Class of Drugs Shows Promise Against Kidney Cancer

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A new class of drugs, that interferes with processes that fuel cell growth, is more effective and better tolerated that the standard-of-care drug for clear cell renal cell carcinoma.

Study Evaluates Incidence of PD-1 Blockade-related Pneumonitis

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Pneumonitis related to the use of PD-1 inhibitor therapy is higher among patients with NSCLC and RCC, and during combination therapy.

Biomarkers Predict Response to TKI Therapy for Metastatic Renal Cell Carcinoma

Biomarkers Predict Response to TKI Therapy for Metastatic Renal Cell Carcinoma

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Presence of certain microRNAs (miRNAs) is predictive of response to TKIs and prognosis for patients with metastatic renal cell carcinoma (mRCC).

Study Better Characterizes Immunotherapy-related Skin Toxicities

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Patients receiving PD-1 or PD-L1 antibodies exhibited papular and nodular eruptions with scale, as well as mucosal lesions with lichenoid features, that were typically manageable with topical steroid treatment.

Comparative Efficacy and Safety of Axitinib Versus Sorafenib in Metastatic Renal Cell Carcinoma: A Systematic Review and Meta-analysis

Comparative Efficacy and Safety of Axitinib Versus Sorafenib in Metastatic Renal Cell Carcinoma: A Systematic Review and Meta-analysis

[Oncotargets and Therapy] This research evaluates the comparative efficacy and safety of axitinib and sorafenib for the treatment of metastatic renal cell carcinoma.

Surgery Improves Survival in Metastatic Kidney Cancer, But Is Little Used

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Surgery to remove a cancerous kidney can often lengthen the lives of patients receiving targeted therapy for metastatic kidney cancer, but only approximately 3 in 10 such patients undergo the procedure.

Genetic Differences Explain Survival Disparity in African Americans With Kidney Cancer

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Several genetic differences uncovered in an analysis of data from The Cancer Genome Atlas (TCGA) are biologically plausible contributing factors for the worse survival of African American patients with clear cell renal carcinoma, even in the era of targeted therapy.

Adjuvant Sorafenib or Sunitinib Not Effective for Local Kidney Cancer

Adjuvant Sorafenib or Sunitinib Not Effective for Local Kidney Cancer

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Adjuvant treatment with sorafenib or sunitinib demonstrated no survival benefit in patients with resected local renal cell carcinoma at high risk for disease recurrence.

Tumor Heterogeneity as a Rationale for a Multi-epitope Approach in an Autologous Renal Cell Cancer Tumor Vaccine

Tumor Heterogeneity as a Rationale for a Multi-epitope Approach in an Autologous Renal Cell Cancer Tumor Vaccine

In this study, researchers sought to characterize a panel of 36 tumor-associated antigens and cellular marker proteins from tumor material of 133 patients with renal cell carcinoma who underwent radical neprhectomy.

Progression-free Survival in Advanced Renal Cell Carcinoma Is Improved With Cabozantinib

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Findings of the randomized, phase 3 METEOR trial demonstrate progression-free survival in patients with advanced renal cell carcinoma is improved with cabozantinib compared with everolimus.

Study Evaluates Effect of Everolimus-induced Stomatitis

Study Evaluates Effect of Everolimus-induced Stomatitis

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Everolimus-induced stomatitis did not negatively affect progression-free survival in patients with various types of cancer, such as breast cancer and renal cell carcinoma.

ASCO: Cabozantinib Increases Progression-Free Survival in RCC

ASCO: Cabozantinib Increases Progression-Free Survival in RCC

Improvements to progression-free survival (PFS) seen across patient subgroups treated with cabozantinib.

Nivolumab  Now FDA Approved for Advanced RCC

Nivolumab Now FDA Approved for Advanced RCC

This newly approved drug operates by targeting the PD-1/PD-L1 cellular pathway.

Diabetes Linked to Worse Survival in Renal Cell Carcinoma

Diabetes Linked to Worse Survival in Renal Cell Carcinoma

For patients with diabetes, poor glycemic control is linked to higher risk of postoperative progression.

Nivolumab Indications Extended to Include Advanced Renal Cell Carcinoma

Nivolumab Indications Extended to Include Advanced Renal Cell Carcinoma

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The FDA extended indications for nivolumab (Opdivo) to include treatment of advanced (metastatic) renal cell carcinoma (RCC).

Specific Genetic Alterations Observed in Papillary Renal-Cell Carcinomas

Specific Genetic Alterations Observed in Papillary Renal-Cell Carcinomas

Type 1 and type 2 carcinomas are characterized by specific genetic alterations; type 2 consists of at least three subtypes.

Forms of Meat Preparation May Increase Renal Cell Carcinoma Risk

Forms of Meat Preparation May Increase Renal Cell Carcinoma Risk

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A recent study has linked an increased risk of kidney cancer to certain meat-cooking mutagens.

Model Developed for Predicting Toxicity-related Treatment Discontinuation in mRCC

Model Developed for Predicting Toxicity-related Treatment Discontinuation in mRCC

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Independent risk factors for toxicity-related treatment discontinuation (TrTD) in patients with metastatic renal cell carcinoma (mRCC).

Questionnaire Effective in Assessing Adverse Events in Renal Cell Carcinoma

Questionnaire Effective in Assessing Adverse Events in Renal Cell Carcinoma

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Frequent adverse events experienced by patients receiving tyrosine kinase inhibitors are hand-foot syndrome and mucositis/stomatitis.

Risk of Cardiovascular Events Higher After Antiangiogenic Therapy for RCC in Persons Older Than 65 Years

Risk of Cardiovascular Events Higher After Antiangiogenic Therapy for RCC in Persons Older Than 65 Years

Sunitinib and sorafenib may be associated with an increased risk of cardiovascular events in older patients with renal cell carcinoma (RCC).

Novel Immunotherapy Shows Promise Against Advanced Renal Cancer

Novel Immunotherapy Shows Promise Against Advanced Renal Cancer

In new clinical trial, Nivolumab raised median survival for patients with advanced renal-cell carcinoma.

Sunitinib Plus Gemcitabine Active in Sarcomatoid, Poor-Risk Renal Cell Carcinoma

Sunitinib Plus Gemcitabine Active in Sarcomatoid, Poor-Risk Renal Cell Carcinoma

Antiangiogenic therapy and cytotoxic therapy are an active and well-tolerated combination for aggressive renal cell carcinoma (RCC).

Cabozantinib Granted Breakthrough Therapy Designation for Kidney Cancer

Cabozantinib Granted Breakthrough Therapy Designation for Kidney Cancer

The FDA has granted Breakthrough Therapy Designation to cabozantinib for treatment of advanced renal cell carcinoma (RCC).

Low Risk of Renal Dysfuntion in Patients With Wilms Tumor Undergoing Partial Nephrectomy

Low Risk of Renal Dysfuntion in Patients With Wilms Tumor Undergoing Partial Nephrectomy

Patients with unilateral Wilms tumor who underwent unilateral radical nephrectomy appear to have low risk for renal dysfunction.

Pembrolizumab and Ipilimumab Combo Safe for Melanoma and Renal Cell Carcinoma

Pembrolizumab and Ipilimumab Combo Safe for Melanoma and Renal Cell Carcinoma

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Pembrolizumab plus low-dose ipilimumab combination considered to have an acceptable safety profile in melanoma or renal cell carcinoma.

Lycopene may decrease risk of renal cell carcinoma in postmenopausal women

Lycopene may decrease risk of renal cell carcinoma in postmenopausal women

A higher intake of lycopene in postmenopausal women may decrease the risk for developing renal cell carcinoma.

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