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RECTIV
Colorectal disorders
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Drug Name:

RECTIV Rx

Generic Name and Formulations:
Nitroglycerin 0.4% (1.5mg/inch); oint; contains lanolin.

Company:
Allergan

Therapeutic Use:

Indications for RECTIV:

Treatment of moderate-to-severe pain associated with chronic anal fissure.

Adult:

Apply using finger covering (eg, plastic-wrap, disposable surgical glove, finger cot). ≥18yrs: 1 inch of ointment intra-anally every 12 hours for up to 3 weeks. Not for oral, ophthalmic, or intravaginal use.

Children:

<18yrs: not recommended.

Contraindications:

Concomitant PDE5 inhibitors (eg, sildenafil, vardenafil, tadalafil). Severe anemia. Increased intracranial pressure.

Warnings/Precautions:

Volume depleted. Hypotension. Cardiomyopathy. CHF. Acute MI. Poor cardiac function. Elderly. Pregnancy (Cat.C). Nursing mothers.

Interactions:

See Contraindications. Hypotension with PDE5 inhibitors, antihypertensive drugs (eg, calcium channel blockers, beta-adrenergic blockers, other nitrates). Potentiated by aspirin. Antagonizes tissue-type plasminogen activator (t-PA); caution. Anticoagulant effect of heparin may be reduced; monitor APTT. Potentiates ergotamine; possible ergotism. Additive vasodilating effects with alcohol; avoid use.

Pharmacological Class:

Nitrate.

Adverse Reactions:

Headache, dizziness, hypotension (including orthostatic hypotension); rare: flushing, allergic reactions, application site reactions (eg, drug rash, exfoliative dermatitis), methemoglobinemia.

How Supplied:

Oint—30g

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