Rectal Cancer

Replacing Neoadjuvant CRT with Multiagent Chemo Not Recommended for Rectal Cancer

Replacing Neoadjuvant CRT with Multiagent Chemo Not Recommended for Rectal Cancer

By

In this study, the impact of advancements in surgical technique and systemic therapy for stage II and III rectal cancers was assessed via a comparison of outcomes after neoadjuvant chemoradiotherapy followed by definitive resection with those for neoadjuvant multiagent chemotherapy without radiation therapy.

Poor Compliance to Adjuvant Chemo Linked to Poorer Survival in Rectal Cancer

Poor Compliance to Adjuvant Chemo Linked to Poorer Survival in Rectal Cancer

By

Poor compliance to NCCN guidelines for adjuvant chemotherapy appears to be associated with poorer overall survival.

Substantial Increase in Use of Neoadjuvant Chemoradiotherapy for Rectal Cancer

Substantial Increase in Use of Neoadjuvant Chemoradiotherapy for Rectal Cancer

By

Use of neoadjuvant chemoradiotherapy (NACRT) before surgery among patients with rectal cancer has substantially increased over the past decade.

Nonoperative Management of Rectal Adenocarcinoma Examined

Nonoperative Management of Rectal Adenocarcinoma Examined

By

Nearly 50% of patients with stage II/III rectal cancer achieve a complete clinical response via neoadjuvant chemoradiation.

Likelihood of Radiation Therapy for Rectal Cancer Affected by Travel Burden

Likelihood of Radiation Therapy for Rectal Cancer Affected by Travel Burden

By

A new study indicates that patient travel distance to an appropriate treatment facility can impact whether radiation therapy is received.

Exercise During Neoadjuvant CRT Less Difficult Than Anticipated for Rectal Cancer

Exercise During Neoadjuvant CRT Less Difficult Than Anticipated for Rectal Cancer

By

Patients with rectal cancer reported aerobic exercise during neoadjuvant chemoradiotherapy to be more enjoyable and less difficult.

Reduced Toxicity, Similar Efficacy Achieved With Novel Regimen for Advanced Rectal Cancer

By

No difference in local efficacy was found between two treatment regimens for colorectal cancer: short-course (5-day) radiation followed by consolidation chemotherapy before surgery and standard 5-week chemoradiation.

Optimal Time for Post-Chemo and -Radiotherapy Rectal Cancer Surgery Pinpointed

Optimal Time for Post-Chemo and -Radiotherapy Rectal Cancer Surgery Pinpointed

Patients who had the procedure eight weeks after chemo and radiation therapy demonstrated the best survival rates.

Dietary Glutamic Acid Intake Linked With Lower CRC Risk

By

Baseline dietary glutamic acid intake is associated with a lower risk for developing colorectal cancer, particularly in people who are not overweight.

Laparascopic Surgery Does Not Improve Outcomes Over Open Resection for Rectal Cancer

Laparascopic Surgery Does Not Improve Outcomes Over Open Resection for Rectal Cancer

Compared with open surgery, laparascopic surgery fails to improve outcomes for patients with stage 2 or 3 rectal cancer.

Resection of CRC Liver Metastases Linked With Higher Risk of Death Among Elderly Patients

Resection of CRC Liver Metastases Linked With Higher Risk of Death Among Elderly Patients

New study data associates the resection of colorectal cancer (CRC) liver metastases with greater risk of postoperative mortality among elderly patients.

Colonoscopy screening may reduce CRC-related mortality

Colonoscopy screening may reduce CRC-related mortality

Patients with colorectal cancer that is detected during a colonoscopy screening are more likely to survive to longer than patients who are not diagnosed until they have symptoms.

Combination of mFOLFOX6 and Radiotherapy Yields Higher pCR in Rectal Cancer

Combination of mFOLFOX6 and Radiotherapy Yields Higher pCR in Rectal Cancer

By

mFOLFOX6 administered concurrently with radiation therapy resulted in a higher pathological complete response in rectal cancer.

Surgery may not be necessary for some patients with rectal cancer

By

Patients with rectal cancer that experienced a complete response had similar 4-year survival rates regardless of whether they had immediate surgery or pursued a watch-and-wait approach.

Wide variation exists in the quality and content of clinical cancer guidelines

By

A review of top clinical guidelines for rectal cancer shows a variety of treatment recommendations.

Chemotherapy first may be helpful in rectal cancer

By

A new phase II study finds that if chemotherapy is offered before radiation and surgery, more patients will be able to tolerate it and receive a full regimen of treatment.

Chemotherapy after radiation does not improve survival of rectal cancer

By

Long-term results of an EORTC trial show that 5- fluorouracil (FU)-based adjuvant chemotherapy after preoperative chemoradiotherapy for patients with cT3-resectable T4 M0 rectal cancer does not improve survival or disease-free survival.

Regorafenib prolongs survival in face of GI cancers

Persons with metastatic colorectal cancer or gastrointestinal stromal tumors may garner some survival benefit from regorafenib after standard treatments have failed.

Early end-of-life talks mean less aggressive care later

Early end-of-life talks are associated with less aggressive care and greater use of hospice services when patients do reach their final days.

FDA Update - September/October 2012

News from the FDA on bosutinib (Bosulif), ziv-aflibercept (Zaltrap), and everolimus oral suspension tablets (Afinitor Disperz).

New colonoscopy schedule mirrors prior advice

Two of three main recommendations for colonoscopy surveillance are now supported by stronger evidence than they were in 2006.

Getting to 'the heart of the bad'

Getting to 'the heart of the bad'

By

I knew Sam's joking was not a sign of joy or happiness but his way of coping, maybe the only way he knew how.

Short-, long-course therapy comparable in T3 rectal cancer

Short-, long-course therapy comparable in T3 rectal cancer

No significant differences in rates of local, distant recurrence; overall survival; or late toxicity.

FDA Update - July/August 2012

News about pertuzumab injection (Perjeta); ondansetron (Zofran); carfilzomib (Kyprolis); Therascreen KRAS RGQ PCR Kit; Prostate Health Index (phi); and Prepopik

Laxative-free virtual colonoscopy can detect large polyps

By

CT colonography can accurately detect adenomas 10 mm or larger in patients who did not undergo laxative-induced bowel cleansing before the procedure.

Colorectal risk defined for childhood cancer survivors

Childhood cancer survivors may need earlier colorectal cancer screening, especially if abdominal radiation was part of their treatment.

Virtual colonoscopy is an accurate screen in seniors

Virtual colonoscopy is an accurate screen in seniors

CT colonography accurately detects cancer and precancerous polyps in persons aged 65 years and older.

Experimental drug shrinks melanoma tumors

Dabrafenib, which targets a genetic mutation that is active in half of melanoma cases, substantially and safely shrank metastatic tumors.

Weight and inactivity impact cancer rates

Weight and inactivity impact cancer rates

Overall US cancer death rates have continued to decline since the early 1990s, but excess weight and lack of sufficient activity contribute to the increased incidence of many cancers.

Cancer pain often undertreated, especially among minorities

One-third of outpatients with breast, prostate, colon/rectum, or lung cancer were receiving insufficient pain treatment, particularly minorities.

Sign Up for Free e-newsletters

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs