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REBIF
Multiple sclerosis
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Drug Name:

REBIF Rx

Generic Name and Formulations:
Interferon beta-1a 8.8mcg/0.2mL, 22mcg/0.5mL, 44mcg/0.5mL; soln for SC inj; contains albumin (human); preservative-free.

Company:
EMD Serono, Inc.

Therapeutic Use:

Indications for REBIF:

Relapsing forms of multiple sclerosis (MS), to decrease the frequency of clinical exacerbations and delay accumulation of physical disability.

Adult:

Pre-medicate with analgesics and/or antipyretics on treatment days to ameliorate flu-like symptoms. Give by SC inj at least 48hrs apart, preferably in the PM. Rotate inj site. Initially 4.4mcg 3 times per week for 2 weeks, titrate to target 22mcg 3 times per week by Week 5; or, initially 8.8mcg 3 times per week for 2 weeks, titrate to target 44mcg 3 times per week by Week 5. See full labeling. May need dose reduction if SGPT >5xULN or leukopenia occurs.

Children:

Not established.

Warnings/Precautions:

Depression; consider discontinuing if occurs. Suicidal ideation. Discontinue immediately if jaundice or other signs of liver dysfunction occur. Active or history of liver disease. Increased serum SGPT >2.5xULN. Alcohol abuse. Seizure disorders. Risk of thrombotic microangiopathy; discontinue if occurs. History of thyroid dysfunction; do thyroid tests every 6 months. Monitor blood counts and liver function at 1, 3, and 6 months after initiation, then periodically thereafter. If myelosuppression, monitor CBCs with differential and platelets more intensively. Elderly. Pregnancy (Cat.C). Nursing mothers.

Interactions:

Risk of hepatic injury with concomitant hepatotoxic drugs or alcohol.

Pharmacological Class:

Immunomodulator.

Adverse Reactions:

Inj site reaction/necrosis, flu-like symptoms, abdominal pain, depression, elevated liver enzymes, hematologic abnormalities; rare: hepatic failure, anaphylaxis (discontinue if occurs).

Generic Availability:

NO

How Supplied:

Prefilled syringe (22mcg, 44mcg)—1, 12; Rebidose autoinjector (22mcg, 44mcg)—12; Titration Pack: Prefilled syringes or Rebidose autoinjectors (6x8.8mcg + 6x22mcg)—1

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