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RAGWITEK
Allergies
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Drug Name:

RAGWITEK Rx

Generic Name and Formulations:
Short ragweed pollen allergen extract (Ambrosia artemisiifolia) 12 Amb a 1-Unit; sublingual tablets.

Company:
Merck & Co., Inc.

Therapeutic Use:

Indications for RAGWITEK:

Short ragweed pollen-induced allergic rhinitis, with or without conjunctivitis, confirmed by (+) skin test or in vitro testing for pollen-specific IgE antibodies. Not for immediate relief of allergic symptoms.

Adult:

Initiate at least 12 weeks before onset of ragweed pollen season and continue throughout the season. Give 1st dose under physician supervision; observe ≥30 mins for signs/symptoms of severe allergic reaction; if tolerated, subsequent doses may be taken at home. ≥18–65yrs: 1 tab daily. Allow complete dissolution under the tongue before swallowing. Avoid food or beverage for 5 mins after dosing.

Children:

<18yrs: not established.

Contraindications:

Severe, unstable, or uncontrolled asthma. History of severe systemic or local allergic reaction. History of eosinophilic esophagitis.

Warnings/Precautions:

Risk of severe allergic reactions (eg, anaphylaxis, laryngopharyngeal restriction); discontinue if occurs. Prescribe auto-injectable epinephrine for emergency use. Underlying conditions that may reduce survival of a serious allergic reaction after epinephrine use (eg, markedly compromised lung function, unstable angina, recent MI, significant arrhythmia, uncontrolled HTN). Moderate or severe asthma. Withhold therapy in acute asthma exacerbation; consider discontinuing if recurrent. Interrupt therapy for oral inflammation or wounds to allow complete healing. Elderly (>65yrs). Pregnancy (Cat. C). Nursing mothers.

Interactions:

Concomitant other allergen immunotherapy: not studied; may increase risk of local or systemic adverse reactions. Avoid concomitant drugs that can potentiate or inhibit effects of epinephrine (eg, beta-adrenergic blockers, alpha-adrenergic blockers, ergot alkaloids, TCAs, levothyroxine, MAOIs, chlorpheniramine, diphenhydramine, [cardiac glycosides, diuretics; monitor for arrhythmias]).

Pharmacological Class:

Allergen extract.

Adverse Reactions:

Throat irritation, pruritus (oral, ear, tongue), oral paresthesia, mouth edema; severe systemic or local allergic reactions, eosinophilic esophagitis (discontinue if occurs).

How Supplied:

Blisters—30, 90

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