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QUADRACEL
Vaccines
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Drug Name:

QUADRACEL Rx

Generic Name and Formulations:
Diphtheria and tetanus toxoids, acellular pertussis; aluminum phosphate adsorbed + inactivated poliovirus vaccine; susp for IM inj; contains 2-phenoxyethanol, and residual amounts of formaldehyde, glutaraldehyde, bovine serum albumin, neomycin, polymyxin B; preservative-free.

Company:
Sanofi Pasteur, Inc.

Therapeutic Use:

Indications for QUADRACEL:

Active immunization against diphtheria, tetanus, pertussis, and poliomyelitis in children 4–6yrs of age: as 5th dose in DTaP series or as 4th or 5th dose in the IPV series following 4 doses of Pentacel and/or Daptacel.

Adult:

Not recommended.

Children:

<4yrs or >6yrs: not established. 4–6yrs: Each dose is 0.5mL IM, given once into deltoid muscle.

Contraindications:

Anaphylaxis associated with any previous dose or component. Encephalopathy within 7 days of a previous pertussis-containing vaccine. Progressive neurologic disorders (eg, infantile spasms, uncontrolled epilepsy, or progressive encephalopathy).

Warnings/Precautions:

Fever (≥105°F within 48 hours), persistent inconsolable crying (≥3 hours within 48 hours), shock (within 48 hours), seizures (within 3 days), Guillain-Barre Syndrome (within 6 weeks) of previous tetanus toxoid-containing vaccine. Immunocompromised. Have epinephrine inj (1:1000) available. Pregnancy (Cat.C).

Interactions:

Concomitant vaccines: see full labeling. Immunosuppressants (eg, radiation, chemotherapy, high-dose steroids): may get suboptimal response.

Pharmacological Class:

DTaP + IPV.

Adverse Reactions:

Inj site reactions (eg, pain, increase in arm circumference, erythema, swelling), mylagia, malaise, headache, fever.

Generic Availability:

NO

How Supplied:

Single-dose vials (0.5mL)—10

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