[Cancer Management and Research] Data from a total of 16,998 patients with breast cancer included in the SEER database were evaluated to determine the prognosis of various treatment options for elderly patients.
[Breast Cancer: Targets and Therapy] This research examines the mechanism of action of L-DOX and its most common side effects and highlight results of its use in clinical trials for the treatment of BC as single agent and in combination with other commonly used chemotherapeutics.
Prophylactic Cranial Irradiation in Small-Cell Lung Cancer: Update on Patient Selection, Efficacy and OutcomesSeptember 21, 2018
[Lung Cancer: Targets and Therapy] This review presents a summary and update of the latest evidence for patient selection, efficacy and outcome of primary treatment, prophylactic cranial irradiation (PCI) in the treatment of patients with SCLC.
Current Status and Dilemma of Second-line Treatment in Advanced Pancreatic Cancer: Is There a Silver Lining?September 14, 2018
[OncoTargets and Therapy] Although first-line therapy is effective, relapse is common; but many patients are good candidates for second-line therapy. This report reviews current published data on second-line therapies for advanced pancreatic cancer.
Long-term Survival Effect of the Interval Between Mastectomy and Radiotherapy in Locally Advanced Breast CancerAugust 31, 2018
[Cancer Management and Research] Retrospective study investigates the effect of radiotherapy on long-term survival in patients who underwent mastectomy for breast cancer at various time intervals.
The Efficacy and Tolerance of High Pressure Oxygen Combined With Chemotherapy in Postoperative Patients With Advanced Gastric CancerAugust 17, 2018
[Translational Cancer Research] In this research, a combination of gastric cancer postoperative with hyperbaric oxygen therapy to explore the clinical application in postoperative chemotherapy for advanced gastric cancer.
[Journal of Hepatocellular Carcinoma] A review of the manifestations, treatments, and challenges associated with hepatocellular cancer pain.
[OncoTargets and Therapy] Evidence increasingly suggests that pembrolizumab has a significant role in first- and second-line therapy for NSCLC. This review presents the results of previous and ongoing studies and discusses biomarkers that can potentially identify eligible candidates for treatment with the PD-L1 inhibitor.
Updates on the Clinical Diagnosis and Management of Ocular Sebaceous Carcinoma: a Brief Review of the LiteratureAugust 03, 2018
[OncoTargets and Therapy] Disease specifics, demographics, clinical presentation, and pathology, plus diagnosis and management of ocular SC are highlighted and discussed, including recent advances in management of this aggressive malignancy.
[Cancer Management and Research] A review of the background and current challenges in 4 key areas of radiotherapy are presented, plus potential future options for creating safe and effective strategies in radiotherapy.
Novel Quinazoline-based Sulfonamide Derivative (3D) Induces Apoptosis in Colorectal Cancer by Inhibiting JAK2-STAT3 PathwayJuly 13, 2018
[OncoTargets and Therapy] Researchers investigated the anticancer effects of a novel sulfonamide derivative in the treatment of colorectal cancer.
Decreased Hepatocellular Carcinoma Tumor Burden With the Achievement of Hepatitis C Virus Sustained Virologic Response: Unlocking the Potential of T-cell-mediated ImmunosurveillanceJuly 06, 2018
[Journal of Hepatocellular Carcinoma] In this case series, the authors present procedure and treatment specifics for 2 patients with HCV who developed HCC, and discuss the potential role of DAA therapy and immunosurveillance.
Combined Microwave Ablation and Minimally Invasive Open Decompression for the Management of Thoracic Metastasis in Breast CancerJune 29, 2018
[Cancer Management and Research] An investigation into the efficacy of microwave ablation and minimally invasive open decompression treatment for breast cancer with thoracic metastases.
[Cancer Management and Research] The prognostic values of overall survival and cancer-specific survival for bone sarcomas of the hands or feet were assessed using Cox proportional hazards regression model with univariate and multivariate analyses.
Andrographolide Potentiates the Antitumor Effect of Topotecan in Acute Myeloid Leukemia Cells Through an Intrinsic Apoptotic PathwayJune 15, 2018
[Cancer Management and Research] In this study, researchers explored the potential of andrographolide and topotecan, separately and together, in the in vitro treatment of the U937 acute myeloid leukemic cell line.
[OncoTargets and Therapy] In a review of cancer stem cells (CSCs)/ovarian cancer stem cells (OCSCs), researchers discuss the implications of immunotherapy development based on studying cancer evolution by CSCs, and targeting OCSC surface markers to develop CAR-T immunotherapy.
Response to Rapamycin Analogs but not PD-1 Inhibitors in PTEN-mutated Metastatic Non-small Cell Lung Cancer With High Tumor Mutational BurdenJune 01, 2018
[Lung Cancer: Targets and Therapy] This case study demonstrates that genomic profiling may still benefit patients who fail checkpoint inhibitor therapy despite having high tumor mutational burden and PD-L1 positivity.
Multiple Treatment Modalities for Brain Metastasis in Patients With EGFR-mutant Non-small Cell Lung CancerMay 25, 2018
[OncoTargets and Therapy] Management of brain metastases in patients with EGFR-mutant NSCLC is controversial. In this study, researchers find combination and sequential treatment with EGFR-TKIs, chemotherapy, and radiotherapy is beneficial.
[Lung Cancer: Targets and Therapy] Italian researchers report on the role of GLI1 in the development of lung cancer, and review its potential as an effective therapy for lung cancer.
[Cancer Management and Research] A review of marginal zone lymphomas, a common and varied group of hematologic malignancies, and their treatment, with a focus on the Bruton's tyrosine kinase ibrutinib.
[Gastrointestinal Cancer: Targets and Therapy] This review presents the most up-to-date molecular, clinical, and therapeutic data, including an overview of a current phase 3 study assessing the efficacy of simultaneous BRAF, EGFR, and MEK inhibition among patients with BRAFV600E-mutant CRC.
Clinicopathological Features and Prognosis in Elderly Gastric Cancer Patients: A Retrospective Cohort StudyApril 27, 2018
[OncoTargets and Therapy] A retrospective study assessed patients with gastric cancer, identifying disease characteristics more prevalent in elderly patients and the effect on prognosis for these patients.
[Breast Cancer: Targets and Therapy] Researchers present a review of the LHRH agonist triptorelin and the use of this agent to induce chemical castration in estrogen-sensitive breast cancer tumors in younger women.
Bax, Bcl-2, and Bax/Bcl-2 as Prognostic Markers in Acute Myeloid Leukemia: Are We Ready for Bcl-2-Directed Therapy?April 13, 2018
[Cancer Management and Research] This report presents an assessment of the relationship of Bax/Bcl-2 expression and the clinical response of patients with AML treated with cytarabine plus daunorubicin, and their potential as biomarkers to predict chemotherapeutic outcomes.
[Gastrointestinal Cancer: Targets and Therapy] This review discusses novel tools and newer technologies that have been employed to address iCCA.
[Breast Cancer: Targets and Therapy] In this retrospective analysis of medical records and estimated costs of treatment, investigators demonstrated that rapid change based on level I evidence is feasible.
[OncoTargets and Therapy] A meta-analysis was conducted to evaluate the effect of abnormal EGFR expression on overall survival (OS) in patients with glioma.
[Journal of Gastrointestinal Oncology] A review of diagnostic parameters and management modalities for checkpoint inhibitor-induced hepatic toxicity is presented.
[OncoTargets and Therapy] This review examines the rationale of olaratumab in the treatment of advanced soft-tissue sarcomas and its emerging role in clinical practice.
[Cancer Management and Research] The presence of comorbidities is thought to play a significant role in the decision to treat patients with NSCLC, and this impacts survival.
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