Capecitabine-induced leukocytoclastic vasculitis under neoadjuvant chemotherapy for locally advanced colorectal cancer
the ONA take:
In this case, the patient, a 61-year-old white female presented with new onset rectal bleeding. Colonoscopy showed a circumferential, centrally ulcerating mass that was palpable from the vagina on pelvic examination. MRI confirmed a 4.5 cm mass with extension through the rectal wall that was inseparable from the vaginal cuff.
Diagnosis was locally advanced rectal cancer, clinically staged as T4N1M0. The patient began the standard protocol of concurrent chemoradiation for locally advanced rectal cancer, using capecitabine (825 mg/m2 twice daily) and radiation (50.4 Gy to the pelvis) over a 5.5-week period. A pruritic maculopapular rash developed over her lower and upper limbs 5 days after initiating therapy. Drug-induced vasculitis was diagnosed, and the culprit drug, capecitabine, was discontinued immediately. Topical treatments improved the rash, and due to limited chemotherapy options, the capecitabine was re-introduced. However, the rash returned 2 days after that.
Prednisone 20 mg daily was administered throughout the remaining 3 weeks of the chemoradiation treatment and capecitabine was continued. The rash began improving approximately 3 days after initiating the prednisone, and the patient completed the concurrent chemoradiation protocol. After which, the prednisone was tapered to 15 mg, then 10 mg, then 5 mg, then 2.5 mg, each dose daily for 5 days, and was then stopped. The patient was able to undergo surgical resection 6 weeks after completing the chemoradiation treatment.
Journal of Gastrointestinal Oncology
Abstract: We describe a case of capecitabine-induced leukocytoclastic vasculitis in a patient with locally advanced rectal cancer under curative neoadjuvant concurrent chemoradiation using capecitabine. After 5 days of the initiation of capecitabine the patient developed a pruritic maculopapular rash in her extremities consistent with vasculitis which was confirmed on skin biopsy without any signs of systemic involvement. Capecitabine was held and the rash was treated with topical steroids with complete resolution of both rash and pruritus. Due to a lack of other alternative chemotherapeutic options and the cutaneous-only involvement of vasculitis, the capecitabine was re-introduced. Two days later, the patient developed an identical maculopapular rash with a similar distribution. Prednisone was initiated while the capecitabine was continued with complete resolution of the rash. The patient successfully completed her curative neoadjuvant chemoradiation therapy treatment without the need to permanently discontinue the capecitabine.
Keywords: Leukocytoclastic vasculitis; capecitabine; colorectal cancer; chemotherapy-associated toxicity
Submitted Dec 18, 2014. Accepted for publication Dec 29, 2014.
This is the first report of capecitabine-induced leukocytoclastic vasculitis and the first report that illustrates the feasibility of controlling cutaneous vasculitis with an oral steroid without interrupting the curative treatment protocol that includes the capecitabine which was the culprit drug.
A 61-year-old Caucasian female with a past medical history of hypertension, rheumatoid arthritis, osteoarthritis, and hyperlipidemia presented with a new onset rectal bleeding. A colonoscopy showed a circumferential, centrally ulcerating mass starting at 2 cm from the anal verge, approaching the sphincter and extending to 8 cm from the anal verge. The mass was palpable from the vagina on pelvic exam. An MRI of the pelvis confirmed a 4.5 cm mass with extension through the rectal wall that was inseparable from the vaginal cuff. Additionally, sub-centimeter perirectal nodes were seen. A CT of the chest showed no evidence of metastatic disease. Biopsy demonstrated a moderately differentiated adenocarcinoma. Final clinical staging was tumor 4 node 2 metastases 0 (T4N1M0) in keeping with locally advanced rectal cancer.
The patient began the standard concurrent chemoradiation for locally advanced rectal cancer (1), using capecitabine and 50.4 Gy of radiation to the pelvis over a 5.5-week period, with planned surgical resection of the rectal tumor 6-8 weeks after the completion of the chemoradiation therapy. Capecitabine was given in a dose of 825 mg/m2 twice daily. Five days after initiating the concurrent chemoradiation therapy, the patient developed a pruritic maculopapular rash over her lower and upper limbs.