ADD THIS DRUG TO MY LIST

Select the drug indication to add to your list

Protamine sulfate
Poisoning/overdose
Compare To Related Drugs
View/Edit/Compare Drugs In My List

Only 4 drugs may be compared at once

Drug Name:

Protamine sulfate Rx

Generic Name and Formulations:
Protamine sulfate 10mg/mL; soln for inj; preservative-free.

Company:
Fresenius Kabi USA

Therapeutic Use:

Indications for Protamine sulfate:

Treatment of heparin overdose.

Adult:

Give by slow IV inj over 10 mins. Determine dose by coagulation studies; dose requirement decreases with time elapsed after heparin administration. 1mg neutralizes ≥100units of heparin; max 50mg/dose.

Children:

Not recommended.

Warnings/Precautions:

Avoid rapid administration. Fish allergy. Previous exposure to protamine (including insulin). Severe left ventricular dysfunction. Abnormal pulmonary hemodynamics. Previous vasectomy. Pregnancy (Cat.C). Nursing mothers.

Interactions:

Incompatible with certain antibiotics (eg, cephalosporins, penicillins).

Pharmacological Class:

Heparin antagonist.

Adverse Reactions:

Hypotension, bradycardia, transient flushing, feeling of warmth, dyspnea, GI upset, lassitude, pulmonary edema, anaphylaxis, cardiovascular collapse, pulmonary vasoconstriction, pulmonary hypertension.

How Supplied:

Vial (5mL)—25; 25mL—1

Sign Up for Free e-newsletters

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs