Risk for Prostate Cancer Not Associated With Vasectomy, Meta-analysis Affirms

Share this content:
Meta-analysis of data from more than 50 studies reaffirms that vasectomy is not associated with increased risk of prostate cancer.
Meta-analysis of data from more than 50 studies reaffirms that vasectomy is not associated with increased risk of prostate cancer.

Vasectomy may not be associated with subsequent high-grade, advanced-stage, or fatal prostate cancer, according to a study published in JAMA Oncology.

Vasectomy is a highly effective long term method of contraception. Previous studies have provided conflicting data that there is a correlation with prostate cancer and vasectomy, and despite decades of study there have been no conclusions.

This meta-analysis had the pooled data from 4 cross-sectional studies including 12,098,221 patients, 16 cohort studies with 2,562,519 patients, and 33 case-control studies including 44,536 patients who underwent vasectomy. The primary outcome of the study measured was any diagnosis of prostate cancer, and secondary outcomes measured was diagnosis of high-grade, advanced, and fatal prostate cancer.

A weakly significant association between vasectomy and prostate cancer was found in the cohort studies (7 studies; adjusted rate ratio, 1.05; 95% CI, 1.02-1.09; P <.001; i2 = 9%), while the case-control studies reported similar, but nonsignificant, findings (6 studies; adjusted odds ratio, 1.06; 95% CI, 0.88-1.29; P =.54; i2 = 37%).

There were also no significant associations observed between vasectomy and high-grade prostate cancer (6 studies; adjusted rate ratio, 1.03; 95% CI, 0.89-1.21; P =.67; i2 = 55%), advanced prostate cancer (6 studies; adjusted rate ratio, 1.08; 95% CI, 0.98-1.20; P =.11; i2 = 18%), and fatal prostate cancer (5 studies; adjusted rate ratio, 1.02; 95% CI, 0.92-1.14; P =.68; i2 = 26%).

The researchers conclude that “although patients should be appropriately counseled, concerns about the risk of prostate cancer should not preclude clinicians from offering vasectomy to couples seeking long-term contraception.”

Reference

1. Bhindi B, Wallis C, Nayan M, et al. The association between vasectomy and prostate cancer: a systematic review and meta-analysis. [published online July 17, 2017]. JAMA Intern Med. doi: 10.1001/jamainternmed.2017.2791

You must be a registered member of ONA to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs