Androgen deprivation therapy may increase risk of cardiac-related death in patients with cardiac issues

Androgen deprivation therapy may increase risk of cardiac-related death in patients with cardiac issues

Men who were treated with androgen deprivation therapy for prostate cancer have a three times increased risk of cardiac problems.

Daily aspirin may lower mortality in nonmetastatic prostate cancer

Daily aspirin may lower mortality in nonmetastatic prostate cancer

Even a small daily dose of aspirin may help lower mortality among men with nonmetastatic prostate cancer, according to research.

Ten portions of tomatoes per week decreases risk of prostate cancer

Ten portions of tomatoes per week decreases risk of prostate cancer

Consuming 10 portions of tomatoes a week can reduce risk for developing prostate cancer by 18%.

For patients with localized prostate cancer, androgen deprivation therapy may be harmful

For patients with localized prostate cancer, androgen deprivation therapy may be harmful

Primary androgen deprivation therapy (PADT) was linked with increased all-cause mortality and prostate cancer-specific mortality.

For patients with low-risk prostate cancer managed with active surveillance, obesity may increase risk of progression

For patients with low-risk prostate cancer managed with active surveillance, obesity may increase risk of progression

Obesity is linked with increased risk of progression of low-risk prostate cancers in active surveillance.

Overdetection of PSA recurrence after radical prostatectomy more likely in older patients

Overdetection of PSA recurrence after radical prostatectomy more likely in older patients

For some men, prostate cancer recurrence may be overdetected, especially in those aged over 70.

Half of patients who die from prostate cancer have metastases at diagnosis

Half of patients who die from prostate cancer have metastases at diagnosis

Researchers sought to determine which types of patients die from prostate cancer in the modern era.

Increased PSA after prostatectomy may not result in metastasis in some men's lifetime

Increased PSA after prostatectomy may not result in metastasis in some men's lifetime

Some patients whose PSA levels become elevated after prostatectomy may die as a result of a cause unrelated to prostate cancer.

Elevated cholesterol associated with prostate cancer recurrence

Elevated cholesterol associated with prostate cancer recurrence

Findings suggest that elevated levels of cholesterol and triglycerides may be linked with greater risk of the prostate cancer recurrence, but normalization of blood fats may reduce risk.

Professional recommendations against prostate cancer screening have little impact on practice

The effect of guidelines recommending that elderly men should not be routinely screened for prostate cancer has been minimal at best, according to a new study.

High HDL may reduce risk of prostate cancer recurrence

High HDL may reduce risk of prostate cancer recurrence

High cholesterol may be associated with an increased risk for developing prostate cancer.

Testosterone may increase risk for developing prostate cancer

Testosterone may increase risk for developing prostate cancer

Testosterone increased the risk for developing prostate cancer in rats.

Aspirin may decrease the risk for developing high-grade prostate cancer

Aspirin may decrease the risk for developing high-grade prostate cancer

Aspirin and other other NSAIDs were associated with a decreased risk for developing an aggressive form of prostate cancer.

Facing prostate cancer—but not alone

Facing prostate cancer—but not alone

Frank dela Rama, a new member of the Oncology Nurse Advisor editorial board, talks about helping men with newly diagnosed prostate cancer learn about and prepare to cope with their disease.

Prostate cancer treatment controversy continues as study finds watchful waiting not enough for some men

An active controversy among oncologists concerns watchful waiting versus more active treatment for prostate cancer.

Men who are uneducated about their prostate cancer have difficulty making treatment decisions

Researchers have discovered that men who are not well educated about their prostate cancer have a much more difficult time deciding on treatment options.

Wild berry may up chemotherapy effectiveness for pancreatic cancer

Wild berry may up chemotherapy effectiveness for pancreatic cancer

Chokeberry extract enhances cytotoxicity of gemcitabine on a single cancer cell line, according to research.

For prostate cancer screening, guidelines have little effect on clinical practice

For prostate cancer screening, guidelines have little effect on clinical practice

Guidelines recommending clinicians not routinely screen elderly men for prostate cancer have had a minimal effect on practice.

ASTRO: Sexual function not compromised in prostate cancer combo treatment

ASTRO: Sexual function not compromised in prostate cancer combo treatment

High rates of preserved sexual function seen with combination beam plus brachytherapy for prostate cancer.

ASTRO: Prostate cancer recovery faster with less androgen deprivation therapy

ASTRO: Prostate cancer recovery faster with less androgen deprivation therapy

Shorter time to testosterone recovery with 18 versus 36 months androgen deprivation therapy.

Certain male baldness pattern associated with increased risk of aggressive prostate cancer

Certain male baldness pattern associated with increased risk of aggressive prostate cancer

Baldness in men at age 45 is linked with an elevated risk for developing aggressive prostate cancer.

For black men with prostate cancer, watchful waiting may be unwise

For black men with prostate cancer, watchful waiting may be unwise

For men with early-stage prostate cancer, watching waiting is not always the best course of action, especially for black patients.

Enzalutamide reduces skeletal-related events in men with advanced castration-resistant prostate cancer

Enzalutamide reduces skeletal-related events in men with advanced castration-resistant prostate cancer

Enzalutamide was found to decrease the risk of skeletal-related events in men with metastatic castration-resistant prostate cancer.

Joint ASCO/CCO guidelines for advanced prostate cancer issued

Joint ASCO/CCO guidelines for advanced prostate cancer issued

Recommendations are for men whose tumors have grown resistant to hormonal therapies were issued jointly by the American Society of Clinical Oncology (ASCO) and Cancer Care Ontario (CCO) in Canada.

Robotic surgery for prostate cancer is widespread in the United States

There has been widespread adoption in the United States of robot-assisted prostatectomy to treat prostate cancer in recent years.

In prostate cancer, watchful waiting may not be best for African Americans

In prostate cancer, watchful waiting may not be best for African Americans

African American men may not benefit from watchful waiting after being diagnosed with low-grade prostate cancer.

For prostate cancer screening, new technique may prove effective

For prostate cancer screening, new technique may prove effective

Researchers have designed a new, non-invasive technique to screen for prostate cancer.

Lacking prostate cancer knowledge linked to greater decisional conflict

Lacking prostate cancer knowledge linked to greater decisional conflict

For economically disadvantaged men with newly diagnosed prostate cancer, poor knowledge about prostate cancer is associated with increased decisional conflict.

Prostate Cancer Prevention Trial identifies men most likely to undergo biopsy

Healthy men participating in the Prostate Cancer Prevention Trial who actively participate in all trial steps are most likely to undergo a biopsy at the end of the trial, according to recent research.

Prostate cancer education is key for patient decision-making

Prostate cancer education is key for patient decision-making

Researchers found that men who aren't well educated about prostate cancer have more difficulty making decisions.

Prostate cancer risk cut by tomatoes

Prostate cancer risk cut by tomatoes

Men who eat more than 10 portions of tomatoes each week have an 18% lower risk of developing prostate cancer.

Upgraded Prostate Cancer Risk Calculator 2.0, with emojis, is available online

A calculator to help men and their doctors assess the risk of prostate cancer has had a major upgrade to enhance men's and their physicians' understanding of a man's risk of prostate cancer.

Men in prostate cancer prevention trial more likely to undergo biopsy

Men in prostate cancer prevention trial more likely to undergo biopsy

Men without prostate cancer taking part in the trial who participate in other aspects are most likely to undergo a challenging biopsy.

Lasting drop in prostate cancer mortality with prostate-specific antigen (PSA)

Lasting drop in prostate cancer mortality with prostate-specific antigen (PSA)

Prostate-specific antigen (PSA) screening is associated with a lasting reduction in prostate cancer mortality, according to a study published online.

Genomic analysis of prostate cancer suggests best plan after surgery

Genomic analysis of prostate cancer suggests best plan after surgery

A genomic tool can help doctors and patients make a more informed decision on the need for radiation therapy after surgery for prostate cancer.

Prior diagnosis of depression worsens outcomes in prostate cancer

Prior diagnosis of depression worsens outcomes in prostate cancer

Men with diagnosed depressive disorders are less likely to pursue definitive treatment options for prostate cancer and more likely to have poorer outcomes.

Robot-assisted surgery for prostate cancer controls disease for 10 years

Robot-assisted surgery to remove cancerous prostate glands is effective in controlling the disease for 10 years, according to a new study.

Tips for Patients and Their Partners for Restoring Intimacy after Prostate Cancer

Tips for Patients and Their Partners for Restoring Intimacy after Prostate Cancer

Although their lives eventually return to normal after treatment, some men have to cope with lingering effects of their treatment that affects their libido or sexual function. Daniel Watter, EdD, offers guidance tips to share with patients who are surviving prostate cancer that can help them through the recovery process.

New epigenetic test could eliminate unnecessary repeat biopsies for prostate cancer

Two independent trials have validated the performance of an epigenetic test that could provide physicians with a better tool to help eliminate unnecessary repeat prostate biopsies.

Genetics is the dominant risk factor for familial breast, prostate, and colorectal cancers

Genetics is the dominant risk factor for familial breast, prostate, and colorectal cancers

A study of people who were adopted identified genetics as the dominant risk factor in familial breast, prostate, and colorectal cancers.

Vasectomy may increase risk of aggressive prostate cancer

Vasectomy may increase risk of aggressive prostate cancer

Vasectomy was associated with a small increased risk of prostate cancer, and a stronger risk for advanced or lethal prostate cancer, according to a new study.

Obtaining 16 cores is better than obtaining 12 cores for prostate cancer detection

Obtaining 16 cores is better than obtaining 12 cores for prostate cancer detection

A research team from Japan found that 16-core biopsy has a slightly higher detection rate than 12-core biopsy.

Bike riding may up prostate cancer risk

Bike riding may up prostate cancer risk

Researchers found that cyclists who bike more may face a higher risk of prostate cancer, but not a greater chance of infertility or erectile dysfunction.

Rates of observation as prostate cancer management vary

Rates of observation as prostate cancer management vary

Rates of observation as management for low-risk prostate cancer vary widely, and primary ADT is not tied to better survival for men with localized prostate cancer.

Robot-assisted surgery effective in controlling prostate cancer for 10 years

Robot-assisted surgery effective in controlling prostate cancer for 10 years

Results of a new study show that robot-assisted surgery to remove cancerous prostate glands is effective in controlling the disease for 10 years.

Link between vasectomy and prostate cancer greater in high-grade cases

Link between vasectomy and prostate cancer greater in high-grade cases

Vasectomy is associated with an increased incidence of prostate cancer overall during extended follow-up, with an elevated risk seen for high-grade and lethal cancer.

Depressed men with prostate cancer have worse outcomes

Depressed men with prostate cancer have worse outcomes

Depressed men with a diagnosis of intermediate- or high-risk prostate cancer have worse overall outcomes.

Doctors steer prostate cancer treatment choices

Doctors steer prostate cancer treatment choices

Physicians who diagnosed low-risk prostate cancer had more influence over the decision to enter active surveillance than did the disease characteristics, according to a case review.

Radiation-induced toxicity risk in prostate cancer predicted by variations in key gene

Key genetic variants may affect how cancer patients respond to radiation treatments, according to a new study.

Researchers Identify New Cancer Metastasis-Suppressor Gene

Researchers Identify New Cancer Metastasis-Suppressor Gene

Researchers searching for a target that would interfere with cancer metastasis identified a new suppressor of metastasis that may lead toward the development of more effective treatments for prostate cancer and other malignant solid tumors.

Hypnosis Relaxation May Help Men Experiencing Hot Flashes After Prostate Cancer

Hypnosis Relaxation May Help Men Experiencing Hot Flashes After Prostate Cancer

Hot flashes are a common side effect of menopausal changes experienced by women; however, they can also be a hormone-related effect experienced by men with prostate cancer.

Study Results Demonstrate A New Prostate Cancer Treatment

Study Results Demonstrate A New Prostate Cancer Treatment

A new study is suggesting a different approach to treating prostate cancer. Researchers at Comprehensive Cancer Centers of Nevada conducted a study in which 790 men with advanced stages of prostate cancer received early chemotherapy.

Study Shows How Tumors Remodel Their Surroundings to Grow

Study Shows How Tumors Remodel Their Surroundings to Grow

The loss of the p62 protein in tumor cells and the surrounding tissue can enhance the growth and progression of tumors, according to research from Sanford Burnham Medical Research Institute. The findings add to the acknowledgement that the stroma is an integral part of cancer initiation, growth, and expansion.

Prostate cancer specialists' recommendations favor their own treatments

Prostate cancer specialists' recommendations favor their own treatments

Specialists who treat prostate cancer agree that active surveillance is an effective option for patients with low-risk prostate cancer; however, most are more likely to recommend the treatment provided by their own specialties.

Enzalutamide Improves Survival in Patients with Advanced Prostate Cancer

Enzalutamide Improves Survival in Patients with Advanced Prostate Cancer

In an international randomized phase III clinical trial, the hormone therapy enzalutamide extended survival in men with metastatic prostate cancer that had progressed during treatment with androgen deprivation therapy.

Active surveillance for low-risk prostate cancer underused

Active surveillance for low-risk prostate cancer underused

Although most prostate cancer specialists believe active surveillance to be effective and underused, fewer endorse active surveillance than other therapies for low-risk prostate cancer.

Unique PET agent traces treatment-resistant prostate cancer

A groundbreaking molecular imaging agent has been developed to help clinicians find as much prostate cancer as possible and determine whether it is responding favorably or not.

Specialists prefer treatments over surveillance for low-risk prostate cancer

Specialists prefer treatments over surveillance for low-risk prostate cancer

Specialists who treat prostate cancer agree that active surveillance is an effective option—yet according to a study most don't recommend it when appropriate for their own patients.

Prostate-cancer surgery prices vary widely

Prostate-cancer surgery prices vary widely

A study from the University of Iowa examined the charge for prostate cancer surgery at 100 hospital all over the United States, and the results showed widely different prices.

Apoptotic Death of Prostate Cancer Cells by a GnRH-II Antagonist

Apoptotic Death of Prostate Cancer Cells by a GnRH-II Antagonist

Gonadotropin-releasing hormone-I (GnRH-I) has attracted strong attention as a hormonal therapeutic tool, particularly for androgen-dependent prostate cancer patients. Here, we investigated the effect of SN09-2 on the growth of PC3 prostate cancer cells.

The importance of patient education in prostate cancer care

The importance of patient education in prostate cancer care

Male patients with prostate cancer, and patients with other genitourinary cancers, need information on how their cancer and its treatment will affect their life.

Prostate cancer biomarkers identified in seminal fluid

Improved diagnosis and management of prostate cancer could result from research that has discovered that seminal fluid contains biomarkers for the disease.

New care guidelines issued for prostate cancer survivors

New care guidelines issued for prostate cancer survivors

New guidelines have been developed for clinical follow-up care for prostate cancer survivors. Issues addressed include health promotion, surveillance for recurrence, and new primaries.

ACS Releases Long-Term Primary Care Guidelines for Prostate Cancer Survivors

ACS Releases Long-Term Primary Care Guidelines for Prostate Cancer Survivors

The American Cancer Society released a set of guidelines addressing the long-term primary care for survivors of prostate cancer. The guidelines outline follow-up care, monitoring for recurrence, and screening for secondary primary cancers. They also reiterate the need to educate survivors about physical exercise and smoking cessation.

Enzyme from antidepressants may aid in developing prostate cancer treatments

An enzyme commonly used as a target for antidepressants may also promote prostate cancer growth, according to an international team of scientists.

MR fusion guided prostate biopsy: A new way to detect prostate cancer

MR fusion guided prostate biopsy: A new way to detect prostate cancer

A new screening technique, MR fusion guided prostate biopsy, holds promise for increased prostate cancer detection.

Prolaris test predicts prostate cancer mortality risk

The Prolaris test distinguished newly diagnosed patients who were likely to die from prostate cancer within 10 years from those with lower risk disease.

Biomarkers in seminal fluid indicate presence and severity of prostate cancer

Biomarkers in seminal fluid indicate presence and severity of prostate cancer

Improved diagnosis and management of prostate cancer could result from research at the research at the University of Adelaide, which has discovered that seminal fluid (semen) contains biomarkers for the disease.

Prostate cancer treatment can delay chemotherapy

Prostate cancer treatment can delay chemotherapy

Researchers have developed a new technique to combat metastatic prostate cancer (which is called castration-resistant), which could delay the start of chemotherapy.

Sexually transmitted infection linked to prostate cancer

Sexually transmitted infection linked to prostate cancer

Many people are unaware that prostate cancer may sometimes be transmitted sexually.

Circumcision may lower prostate cancer risk

Circumcision may lower prostate cancer risk

Circumcision appears to confer a protective effect against the development of prostate cancer, according to research published online.

Antidepressants may slow prostate cancer growth

Antidepressants may slow prostate cancer growth

There's new evidence that certain drugs used to treat depression might also help stop the growth of prostate cancer.

ASCO: New drug effective for metastatic prostate cancer

ASCO: New drug effective for metastatic prostate cancer

Enzalutamide, an oral androgen-receptor inhibitor, is superior to placebo for the treatment of metastatic prostate cancer before chemotherapy, according a study.

Informed consent plays large in prostatectomy litigation

Informed consent plays large in prostatectomy litigation

Claims of not receiving proper informed consent and clinical performance are the main issues that arise in radical prostatectomy malpractice lawsuits.

Docetaxel + ADT ups survival in metastatic prostate cancer

Docetaxel + ADT ups survival in metastatic prostate cancer

Upfront standard androgen deprivation therapy plus six cycles of docetaxel significantly improves overall survival compared with ADT alone in men with metastatic hormone-sensitive prostate cancer.

Safe to postpone ADT in men with asymptomatic prostate cancer and rising PSA levels

Safe to postpone ADT in men with asymptomatic prostate cancer and rising PSA levels

For the approximately 60,000 men in the United States with prostate cancer who are asymptomatic after radical primary treatment yet have a PSA relapse, it's safe to postpone androgen deprivation therapy, a study presented at the 2014 American Society of Clinical Oncology Annual Meeting concluded.

Metastatic tumor sites predict OS in castration resistant prostate cancer

Metastatic tumor sites predict OS in castration resistant prostate cancer

The site of metastatic tumors powerfully predicts overall survival (OS) among men with metastatic castration resistant prostate cancer (mCRPC), confirms a meta-analysis presented at the 2014 American Society of Clinical Oncology Annual Meeting.

Aggressive treatment doesn't benefit older, sicker men with early-stage prostate cancer

Treating older men with early stage prostate cancer who also have other serious health problems with aggressive therapies does not help them live longer and, in fact, can be detrimental.

Epigenetic test for prostate cancer markers valuable

Epigenetic test for prostate cancer markers valuable

A commercial test designed to rule out the presence of genetic biomarkers of prostate cancer could exclude the need for repeat prostate biopsies in many patients.

Targeted biopsies may trigger prostate cancer reclassification

Targeted biopsies may trigger prostate cancer reclassification

Targeted prostate biopsy using multi-parametric magnetic resonance imaging-ultrasound fusion may lead to reclassification of prostate cancer that was initially diagnosed as low-risk, according to research.

Vitamin D deficiency may have ties to aggressive prostate cancer

Vitamin D deficiency was an indicator of aggressive prostate cancer and spread of the disease in men who underwent their first prostate biopsy because of abnormal PSA test and/or DRE results.

Survival benefit associated with aggressive prostate cancer treatment weakens with comorbidity

Survival benefit associated with aggressive prostate cancer treatment weakens with comorbidity

For men with early-stage prostate cancer, the cancer-specific survival benefit associated with aggressive prostate cancer treatment is reduced with increasing comorbidity, according to a study.

Electronic nose sniffs out prostate cancer in urine samples

A novel noninvasive technique can detect prostate cancer using an electronic nose.

Comparisons across tumors improve identification of cancer-associated genes from microarrays

A new gene expression analysis approach for identifying cancer genes challenges the current paradigm of microarray data analysis.

Model predicts therapy outcomes for prostate cancer with bone metastasis

A new computational model that simulates bone metastasis of prostate cancer has the potential to rapidly assess experimental therapy outcomes and help develop personalized medicine for patients.

Low testosterone may indicate worsening of low-risk prostate cancer

For men with low-risk prostate cancer, low levels of testosterone may indicate a worsening of their disease, concluded a new study.

Chronic inflammation may be linked to aggressive prostate cancer

The presence of chronic inflammation in benign prostate tissue was associated with high-grade, or aggressive, prostate cancer.

Electronic nose distinguishes prostate cancer from BPH

Electronic nose distinguishes prostate cancer from BPH

The ChemPro 100-electronic nose can discriminate prostate cancer from benign prostatic hyperplasia using urine headspace, according to a study.

Low testosterone level may entail prostate cancer reclassification

Low testosterone level may entail prostate cancer reclassification

Men under active surveillance for prostate cancer who have reductions in testosterone levels may be at increased risk for disease reclassification, according to research.

New target for prostate cancer resistant to hormone therapies

A protein called BET bromodomain protein 4 binds to the androgen receptor downstream of where current therapies work, where it targets androgen receptor signaling. This new study suggests a way to block hormones, since prostate cancer that becomes resistant to current treatments might remain sensitive to a drug that targets BET bromodomain proteins.

Preventing radiotherapy-associated sexual dysfunction in prostate cancer

Preventing radiotherapy-associated sexual dysfunction in prostate cancer

Sexual dysfunction is a common and distressing side effect of prostate cancer treatment. Two new reports from randomized clinical trials offer mixed results for adjuvant pharmacotherapy intended to prevent erectile dysfunction in men undergoing radiotherapy for prostate cancer.

Six months hormone therapy plus radiation therapy improves prostate cancer survival

Men with prostate cancer that is small and confined to the prostate gland but at risk of growing, do better if they are treated with radiotherapy combined with androgen deprivation therapy.

Lack of vitamin D may increase risk of aggressive prostate cancer

Lack of vitamin D may increase risk of aggressive prostate cancer

Severe vitamin D deficiency linked with higher grade and stage of prostate tumors, according to research.

Multiparametric MRI accurately detects prostate cancer

Multiparametric MRI accurately detects prostate cancer

Multiparametric MRI is highly accurate for the detection of prostate cancer in patients with clinically low-risk cancer; accuracy is highest with larger cancer volume and higher Gleason grade.

Survey offers insight on coping with advanced prostate cancer

Survey offers insight on coping with advanced prostate cancer

Ninety-one men and 100 caregivers shared their thoughts on what worries them most when advanced prostate cancer becomes a way of life.

Blood-based biomarker may determine enzalutamide resistance in prostate cancers

Blood-based biomarker may determine enzalutamide resistance in prostate cancers

Men with metastatic, castration-resistant prostate cancer who started treatment with enzalutamide and had the molecule AR-V7 present in CTCs obtained prior to treatment had a worse response to enzalutamide.

Chronic prostate inflammation associated with prostate cancer

Chronic prostate inflammation associated with prostate cancer

The presence of chronic inflammation in benign prostate tissue samples is associated with prostate cancer, especially high-grade disease, according to a study.

Adherence rates for prostate cancer quality of care measures low

Adherence rates for prostate cancer quality of care measures low

Adherence to established prostate cancer quality of care measures is frequently low, with considerable regional variation.

Primary androgen deprivation ineffective for most early prostate cancer

In a study of men with early stage prostate cancer, those who received androgen deprivation as their primary treatment instead of surgery or radiation did not live any longer than those who received no treatment.

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