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PROQUAD
Vaccines
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Drug Name:

PROQUAD Rx

Generic Name and Formulations:
Measles, mumps, rubella, and varicella viruses live, attenuated; lyophilized pwd for SC inj after reconstitution; contains neomycin (trace), human albumin; preservative-free.

Company:
Merck & Co., Inc.

Therapeutic Use:

Indications for PROQUAD:

Measles, mumps, rubella, and varicella immunization; may be used if a 2nd dose of measles, mumps, rubella, and varicella vaccine is needed.

Adult:

Not recommended.

Children:

Give SC in deltoid area or upper anterolateral thigh. <12 months or ≥13yrs: not recommended. 12 months–12yrs: 1 dose of 0.5mL. If a 2nd dose is needed, give at 4–6yrs.

Contraindications:

Egg, gelatin, or neomycin hypersensitivity. Blood dyscrasias. Leukemia, lymphoma, or other bone marrow or lymphatic malignancy. Primary or acquired immunodeficiency. Family history of congenital or hereditary immunodeficiency. Immunosuppressant therapy. Active untreated tuberculosis. Fever >101.3°F. Pregnancy (Cat.X); avoid pregnancy for 3 months after vaccination.

Warnings/Precautions:

Have epinephrine inj (1:1000) available. History of febrile convulsions or cerebral injury. Thrombocytopenia. Avoid contact with high-risk individuals susceptible to varicella for 6 weeks after vaccination. Post-exposure prophylaxis for measles, mumps, rubella, or varicella. HIV-infected children. Contains albumin; monitor for possible infection transmission (eg, viruses, Creutzfeldt-Jakob disease). Nursing mothers: not recommended.

Interactions:

Immunosuppressants (see Contraindications). Avoid salicylates for 6 weeks after vaccination. Defer vaccination for at least 3 months after blood or plasma transfusions or immune globulins. Avoid immune globulin administration for 1 month after vaccination. Separate dosing of measles-containing vaccine by 1 month. If 2nd dose of varicella-containing vaccine needed, separate by 3 months. Concomitant other vaccines: see full labeling. May interfere with tuberculin skin test.

Pharmacological Class:

MMR+Var.

Adverse Reactions:

Inj site reactions, fever, irritability, rash; others.

Note:

Report adverse events to VAERS by calling (800) 822-7967.

How Supplied:

Single-dose vials—10 (w. diluent)

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