Prognosis

Prolactin Expression May Indicate Better Prognosis for Patients With TNBC

Prolactin Expression May Indicate Better Prognosis for Patients With TNBC

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Expression of this hormone receptor may indicate a less aggressive subtype of triple-negative breast cancer and better prognosis for patients with the disease.

Evolutionary Theory Predicts Progression of Barrett's Esophagus to Esophageal Adenocarcinoma

Evolutionary Theory Predicts Progression of Barrett's Esophagus to Esophageal Adenocarcinoma

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Applying evolutionary theory improves the accuracy of predicting in which patients Barrett's esophagus will progress to esophageal adenocarcinoma.

Biomarkers Predict Response to TKI Therapy for Metastatic Renal Cell Carcinoma

Biomarkers Predict Response to TKI Therapy for Metastatic Renal Cell Carcinoma

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Presence of certain microRNAs (miRNAs) is predictive of response to TKIs and prognosis for patients with metastatic renal cell carcinoma (mRCC).

Age-Related Prognosis in Breast Cancer Varies by Subtype

Age-Related Prognosis in Breast Cancer Varies by Subtype

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Survival among women age 40 years and younger with breast cancer appears to vary according to breast cancer subtype, with age particularly prognostic for women with luminal type breast cancers.

Advanced Cancer Patients Often Unaware That They Are More Optimistic About Their Prognosis Than Their Oncologists

Advanced Cancer Patients Often Unaware That They Are More Optimistic About Their Prognosis Than Their Oncologists

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Most patients with advanced cancer report far more optimistic expectations for survival prognosis than their oncologists because patients misunderstand their oncologists' clinical judgment.

Hypermutated Hotspots Are Biomarkers Predictive of Better Outcomes in Breast Cancer

Hypermutated Hotspots Are Biomarkers Predictive of Better Outcomes in Breast Cancer

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Patients with kataegis, a recently discovered phenomenon in which multiple mutations cluster in a few hotspots in a genome, have less invasive tumors and better prognoses.

Telomere Length Predicts Risk for Delayed Recovery in Pediatric Patients With AML

Telomere Length Predicts Risk for Delayed Recovery in Pediatric Patients With AML

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Telomere length is predictive for determining which children treated for AML are at highest risk for delayed recovery, a finding that may have significant implications for treatment-related morbidity and mortality.

Biochemical Marker Is a Better Predictor of Adverse Effects in Patients with Non-small Cell Lung Cancer

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Albumin concentration with an established cutoff point is proven a better predictor of both chemotherapy toxicity and survival in patients with advanced lung cancer.

Progression-free and Overall Survival Better With Mutations Affecting DNA Repair Genes in Ovarian Cancer

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Women with advanced ovarian cancer who had mutations affecting DNA repair genes had longer progression-free and overall survival than women without the mutations.

Disparities Related to Race, Insurance, and Facility Type Affect Use of Genetic Assay in Breast Cancer

Disparities Related to Race, Insurance, and Facility Type Affect Use of Genetic Assay in Breast Cancer

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Use and clinical implications of a test commonly used to predict the aggressiveness of early stage ER-positive breast cancer is influenced by patient's race, insurance, and type of facility.

Prolonged Nightly Fasting May Reduce Breast Cancer Recurrence Risk

Prolonged Nightly Fasting May Reduce Breast Cancer Recurrence Risk

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Prolonged nightly fasting may reduce the risk of recurrence for patients with breast cancer.

Risk Stratification and Treatment Options Differ for Male and Female Patients With Breast Cancer

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Optimal risk stratification differs between male and female breast cancers. Outcomes for male patients with breast cancer were not significantly correlated with histologic grade, unlike for female patients.

Serum Vitamin D Levels Predict Adverse Pathology at Prostatectomy

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Both insufficiency and deficiency of serum vitamin D correlated with an increased risk of unfavorable pathology in men undergoing radical prostatectomy for prostate cancer.

Proposed Regimen for Ovarian Cancer is Aggressive, But Could Achieve a 50% Cure Rate

Proposed Regimen for Ovarian Cancer is Aggressive, But Could Achieve a 50% Cure Rate

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Combining a maximal debulking strategy and intraperitoneal chemotherapy could maximize the chance of achieving a cancer-free state, as explained in a recent clinical perspective piece.

Inherited Genetic Markers Predictive of Survival Prognosis for Patients with Melanoma

Inherited Genetic Markers Predictive of Survival Prognosis for Patients with Melanoma

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Prognosis for patients with cutaneous melanoma may be predicted by an inherited genetic marker providing a personalized tool to gauge a person's survival and determine if closer monitoring is needed in the years following surgery.

Study Identifies Main Risk Factors for Associated Lymphoma in Patients with Lymphomatoid Papulosis

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Lymphomatoid papulosis (LyP) is an indolent cutaneous lymphoma; however, prognosis is worse if LyP is associated with lymphoma. A review of FSGCL dermatology departments identifies main risk factors and frequency of associated lymphoma.

Depressed Head and Neck Cancer Patients Have Lower Survival and Higher Recurrence Risk

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Depression is a significant predictor of 5-year survival and recurrence in patients with head and neck cancer. These findings represent one of the largest studies to report on the impact of depression on cancer survival.

Biomarker Is Diagnostic of Early Lung Cancer and Prognostic of Survival

Biomarker Is Diagnostic of Early Lung Cancer and Prognostic of Survival

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Researchers identified a biomarker that detects the most common type of lung cancer in its earliest stage. The discovery could one day change how long lung cancer patients live.

Screen and Detection for Early Stage Breast Cancers May Prevent Invasive Disease

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Screening for and treatment of ductal carcinoma in situ (DCIS) is found to prevent subsequent invasive cancer.

Action of Signaling Pathway Surprises Researchers Investigating Brain Tumor Development

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A signaling pathway present in most organisms suppresses the formation of specific types of brain tumor.

EPclin Score Provides More Prognostic Information for Residual Distant Recurrence in ER+/HER2- Breast Cancer

EPclin Score Provides More Prognostic Information for Residual Distant Recurrence in ER+/HER2- Breast Cancer

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EndoPredict (EP) provided superior information to the Oncotype DX recurrence score (RS) for distant recurrence (DR) in overall, N+, and N- patient populations, and also pinpointed a low-risk patient group who may not need chemotherapy.

Mathematical Modeling Can Help Predict Impact of Surgery on Cancer Metastasis

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The size of a surgically removed tumor is generally thought to relate to the risk of metastasis; however, tumor cells metastasize at different times therefore the rate of spread is difficult to assess. A mathematical model was developed to calculate the relationship between tumor size and the relative risk of recurrence after surgery.

Personalized Drug Screen Aids Treatment Selection for Patients with Multiple Myeloma

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A personalized testing method may quickly and more accurately predict the effectiveness of a treatment for multiple myeloma in individual patients. The process may also aid patients with leukemia or lymphoma.

Network of Thread-like Branches Enables Brain Tumors to Avoid Effects of Treatment

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Incurable astrocytomas grow into healthy brain tissue like mycelium. Therefore, these tumors cannot be completely removed by surgery and invariably start growing again at some point despite intensive treatment.

Blood Test Can Guide Treatment Sequencing for Pancreatic Cancer

Blood Test Can Guide Treatment Sequencing for Pancreatic Cancer

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A widely available, inexpensive blood test can predict outcomes and guide treatment in pancreatic cancer; however, only 1 in 5 US patients with the disease have the blood test.

Breastfeeding Associated With A Reduced Risk of Aggressive Breast Cancer

Breastfeeding Associated With A Reduced Risk of Aggressive Breast Cancer

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A large international study shows that breastfeeding is associated with a lower risk of developing hormone-receptor-negative breast cancer. This breastfeeding meta-analysis shows the risk was reduced by up to 20% in women who breastfed.

Double Enzyme Hit May Explain Common Cancer Drug Side Effect

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Many types of leukemia are caused by loss of enzymes such as Pten, or conversely, the over-activation of enzymes that normally enhance cell proliferation, such as Shp2. But researchers have now found that a lack of both Pten and Shp2 results in an inability produce and sustain enough red blood cells.

Gene Signature May Predict Survival Outcomes for Some Children With Rhabdomyosarcoma

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Among children with intermediate-risk rhabdomyosarcoma that is negative for a fusion gene, those who had a high score of the specific gene signature MG5 had poorer survival outcomes compared with those who had a low score of MG5.

Gene Therapy Doubles Survival in Recurrent Glioblastoma

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An experimental gene therapy essentially doubled the overall survival of patients with recurrent glioblastoma compared with the current standard of care.

Study Reveals New Driver for Assessing Cancer Survival and Drug Sensitivity

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Cancer specialists have long looked at genetic mutations and DNA copy changes to predict patient survival and drug sensitivity. A study has opened up yet another avenue for understanding why some people live longer or respond better to treatment.

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