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PROCARDIA XL
Angina
Hypertension
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Drug Name:

PROCARDIA XL Rx

Generic Name and Formulations:
Nifedipine 30mg, 60mg, 90mg; ext-rel tabs.

Company:
Pfizer Inc.

Therapeutic Use:

Indications for PROCARDIA XL:

Vasospastic and chronic stable angina.

Adult:

Swallow whole. Initially 30 or 60mg once daily, titrate over 7–14 days; usual max 90mg/day.

Children:

Not established.

Warnings/Precautions:

Aortic stenosis. Severe obstructive coronary artery disease. Avoid administration within 1–2 weeks post MI or in acute coronary syndrome. Heart failure. GI narrowing/ulcers (tabs). Monitor blood pressure initially and during titration. Avoid abrupt cessation. Pregnancy (Cat.C). Nursing mothers.

Interactions:

Severe hypotension, angina, and CHF possible with beta-blockers. Avoid concomitant phenytoin or CYP3A4 inducers; consider alternative antihypertensive therapy. Avoid concomitant grapefruit or grapefruit juice. Potentiated by CYP3A inhibitors (eg, fluconazole, itraconazole, clarithromycin, erythromycin, nefazodone, fluoxetine, saquinavir, indinavir, nelfinavir), or cimetidine; consider initiating nifedipine at lowest dose. Potentiates digoxin (monitor). Hypotension possible with fentanyl. GI obstruction possible with H2-blockers, opiates, NSAIDs, laxatives, anticholinergics, levothyroxine, neuromuscular blockers. Monitor oral anticoagulants, quinidine. Taper beta-blockers before initiating nifedipine.

See Also:

PROCARDIA

Pharmacological Class:

Calcium channel blocker (CCB) (dihydropyridine).

Adverse Reactions:

Edema, dizziness, nausea, headache, flushing, weakness, hypotension, fatigue, constipation, palpitations, muscle cramps; rare: increased angina, acute MI, elevated enzymes.

How Supplied:

Tabs 30mg, 60mg—100, 300; 90mg—100; Caps—100

Indications for PROCARDIA XL:

Hypertension.

Adult:

Swallow whole. Initially 30 or 60mg once daily, titrate over 7–14 days; max 120mg/day.

Children:

Not established.

Warnings/Precautions:

Aortic stenosis. Severe obstructive coronary artery disease. Heart failure. GI narrowing/ulcers (tabs). Monitor blood pressure initially and during titration. Avoid abrupt cessation. Pregnancy (Cat.C). Nursing mothers.

Interactions:

Severe hypotension, angina, and CHF possible with beta-blockers. Avoid concomitant phenytoin or CYP3A4 inducers; consider alternative antihypertensive therapy. Avoid concomitant grapefruit or grapefruit juice. Potentiated by CYP3A inhibitors (eg, fluconazole, itraconazole, clarithromycin, erythromycin, nefazodone, fluoxetine, saquinavir, indinavir, nelfinavir), or cimetidine; consider initiating nifedipine at lowest dose. Potentiates digoxin (monitor). Hypotension possible with fentanyl. GI obstruction possible with H2-blockers, opiates, NSAIDs, laxatives, anticholinergics, levothyroxine, neuromuscular blockers. Monitor oral anticoagulants, quinidine. Taper beta-blockers before initiating nifedipine.

Pharmacological Class:

Calcium channel blocker (CCB) (dihydropyridine).

Adverse Reactions:

Edema, dizziness, nausea, headache, flushing, weakness, hypotension, fatigue, constipation, palpitations, muscle cramps; rare: increased angina, acute MI, elevated enzymes.

How Supplied:

Tabs 30mg, 60mg—100, 300; 90mg—100

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