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Prilocaine HCl Injection
Anesthetics
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Drug Name:

Prilocaine HCl Injection Rx

Generic Name and Formulations:
Prilocaine HCl 40mg/mL; soln for inj.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Prilocaine HCl Injection:

Local anesthesia in dentistry by nerve block or infiltration techniques.

Adult:

Maxillary infiltration: initially 1–2mL; max recommended dose within a 2-hour period: <70kg: 8mg/kg; ≥70kg: 600mg. Elderly, debilitated, acutely ill: reduce dose.

Children:

<10yrs: use Clarks rule to calculate dose.

Contraindications:

Congenital or idiopathic methemoglobinemia.

Warnings/Precautions:

Have resuscitative equipment, oxygen, and standard protocol for management of malignant hyperthermia available. G6PD deficiency. Severe shock. Heart block. Hepatic disease. Impaired cardiovascular function. Head and neck block. Monitor cardiovascular and respiratory vital signs. Pregnancy (Cat.B). Nursing mothers.

Interactions:

Risk of methemoglobinemia with sulfonamides, acetaminophen, acetanilid, aniline dyes, benzocaine, chloroquine, dapsone, naphthalene, nitrates and nitrites, nitrofurantoin, nitroglycerin, nitroprusside, pamaquine, para-aminosalicylic acid, phenacetin, phenobarbital, phenytoin, primaquine, quinine.

Pharmacological Class:

Local anesthetic (amide-type).

Adverse Reactions:

Swelling and persistent paresthesia of lips, oral tissue; CNS effects (eg, excitation, depression, restlessness, anxiety, dizziness, tremors), cardiovascular effects (eg, bradycardia, hypotension, cardiovascular collapse), allergic-type reactions, neurologic effects, increased creatinine phosphokinase.

Note:

Formerly known under the brand name Citanest Plain Dental.

How Supplied:

Contact supplier.

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