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PRIALT
Nonnarcotic analgesics
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Drug Name:

PRIALT Rx

Generic Name and Formulations:
Ziconotide acetate 25mcg/mL, 100mcg/mL; soln for intrathecal infusion; preservative-free.

Company:
Jazz Pharmaceuticals plc

Therapeutic Use:

Indications for PRIALT:

Management of severe chronic pain in patients for whom intrathecal therapy is warranted and who are intolerant of or refractory to other treatment (eg, systemic analgesics, adjunctive therapies, intrathecal morphine).

Adult:

Give by intrathecal infusion using appropriate microinfusion device and procedures. Individualize; see literature. Initial: up to 2.4mcg/day (0.1microgram/hr); titrate in increments of up to 2.4mcg/day (0.1mcg/hr) at intervals of up to 2–3 times per week; max 19.2mcg/day (0.8mcg/hr) by day 21.

Children:

Not recommended.

Contraindications:

History of psychosis. Inj site infections. Uncontrolled bleeding diathesis. Spinal canal obstruction.

Warnings/Precautions:

Discontinue if infection, cognitive impairment, hallucinations, mood changes, or impaired consciousness occur. Reduce dose or discontinue if myasthenias, myalgia, or persistent increases in serum creatine kinase occur. Hepatic or renal impairment. Elderly. Labor & delivery. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Concomitant intrathecal opiates: not recommended. CNS effects potentiated by other CNS depressants, antiepileptics, neuroleptics, diuretics; discontinue ziconotide if occurs.

Pharmacological Class:

Analgesic (non-opioid N-type calcium channel blocker).

Adverse Reactions:

Dizziness, GI upset, fever, headache, somnolence, nystagmus, asthenia, ataxia, abnormal vision, dysesthesia, parasthesia, urinary retention, psychiatric effects (eg, hallucinations, mania), cognitive/memory impairment (eg, confusion, aphasia, stupor), worsening depression/suicidal ideation.

How Supplied:

Soln single-use vial
25mcg/mL (20mL)—1
100mcg/mL (1mL, 5mL)—1

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