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Prednisone INTENSOL
Corticosteroid-responsive disorders
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Drug Name:

Prednisone INTENSOL Rx

Generic Name and Formulations:
Prednisone 5mg; per 1mL; concentrated soln; contains alcohol 30%.

Company:
Roxane Laboratories, Inc.

Therapeutic Use:

Indications for Prednisone INTENSOL:

Corticosteroid-responsive disorders.

Adults and Children:

See literature. Initially 5mg–60mg daily. Intensol: mix with liquid or semi-solid food.

Contraindications:

Systemic fungal infections. Live vaccines.

Warnings/Precautions:

Tuberculosis. Latent amebiasis. Strongyloides infestation. Hypothyroidism. Ocular herpes simplex. Cirrhosis. Renal insufficiency. If exposed to chickenpox or measles, consider prophylactic passive immune therapy. Ulcerative colitis if perforation pending. Peptic ulcer. Diverticulitis. Intestinal anastomoses. Myasthenia gravis. Hypertension. Osteoporosis. Diabetes. Kaposi's sarcoma. Supplement with additional steroids in physiologic stress. Avoid abrupt cessation. May increase risk and mask signs of infection. May cause electrolyte imbalances, adrenocortical insufficiency, psychotic derangements. Alternate, intermittent, or single-daily doses at 8AM minimize adrenal suppression. Use lowest effective dose. Monitor weight, growth, fluid and electrolyte balance. Pregnancy. Nursing mothers.

Interactions:

Barbiturates, hydantoins, rifampin, other hepatic enyzme inducers may decrease effects. Potentiated by ketoconazole, troleandomycin. Excretion of high-dose aspirin increased. Caution with diuretics, digoxin, aspirin in hypoprothrombinemia. Potentiated by oral contraceptives. Monitor oral anticoagulants.

See Also:

Prednisone oral solution

Pharmacological Class:

Glucocorticoid.

Adverse Reactions:

HPA axis suppression, increased susceptibility to infection, glaucoma, cataracts, secondary infections, hypokalemia, hypocalcemia, hypernatremia, hypertension, CHF, psychic disorders, myopathy, osteoporosis, peptic ulcer, dermal atrophy, increased intracranial pressure, carbohydrate intolerance.

How Supplied:

Soln—120mL, 500mL; Intensol—30mL (w. dropper)

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