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PLIAGLIS
Topical pain relief
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Drug Name:

PLIAGLIS Rx

Generic Name and Formulations:
Lidocaine 7%, tetracaine 7%; emulsion cream.

Company:
Galderma Laboratories, Inc.

Therapeutic Use:

Indications for PLIAGLIS:

Local analgesia for superficial dermatological procedures (eg, dermal filler injection, pulsed dye laser therapy, facial laser resurfacing, laser-assisted tattoo removal).

Adult:

Do not exceed recommended dose or duration. Apply to intact skin prior to procedure; spread evenly and thinly across treatment area using a metal spatula or tongue depressor. Dermal filler inj or facial laser ablation: apply for 20–30 mins. Laser-assisted tattoo removal: apply for 60 mins. Amount (length) to apply: see full labeling.

Children:

Not established.

Contraindications:

PABA hypersensitivity.

Warnings/Precautions:

Risk of methemoglobinemia. Severe hepatic impairment. Pseudocholinesterase deficiency. Avoid contact with eyes, mucous membranes, or areas with a compromised skin barrier (eg, broken or inflamed). Do not ingest; may be toxic to children and pets. Acutely ill. Debilitated. Elderly. Pregnancy (Cat.B). Nursing mothers.

Interactions:

Toxicity may be potentiated by Class I antiarrhythmics (eg, tocainide, mexiletine); caution. Additive effects with other local anesthetics; consider the amount absorbed from all formulations.

Pharmacological Class:

Topical anesthetic (amide-type + ester-type).

Adverse Reactions:

Localized reactions (eg, erythema, skin discoloration, edema), allergic reactions (eg, urticaria, angioedema, bronchospasm, shock).

Metabolism:

Lidocaine: hepatic.

Elimination:

Lidocaine: renal.

Generic Availability:

NO

How Supplied:

Cream—30g, 100g

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