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PLAVIX
Thromboembolic disorders
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Drug Name:

PLAVIX Rx

Generic Name and Formulations:
Clopidogrel (as bisulfate) 75mg, 300mg; tabs.

Company:
BMS/Sanofi Pharmaceuticals Partnership

Therapeutic Use:

Indications for PLAVIX:

To reduce the rate of MI and stroke in patients with: non-ST-segment elevation acute coronary syndrome (unstable angina/non-ST-elevation MI) or acute ST-elevation MI; history of recent MI, recent stroke, or established peripheral arterial disease; see full labeling.

Adult:

Acute coronary syndrome (give with aspirin): initially give one 300mg loading dose, then continue at 75mg once daily. Recent MI, recent stroke, or established peripheral arterial disease: 75mg once daily without a loading dose.

Children:

Not established.

Contraindications:

Active pathologic bleeding (eg, peptic ulcer, intracranial hemorrhage).

Warnings/Precautions:

CYP2C19 poor metabolizers: diminished effectiveness in those who are homozygous for nonfunctional alleles of the CYP2C19 gene. Perform testing for the CYP2C19 genotype before starting therapy; consider alternative treatment if identified. Increased risk of bleeding. Premature discontinuation increases risk of cardiovascular events; if temporarily discontinued (eg, to treat bleeding or surgery; if possible, interrupt therapy for 5 days before such surgery); restart as soon as possible. Pregnancy (Cat.B). Nursing mothers: not recommended.

Interactions:

Avoid concomitant CYP2C19 inhibitors (eg, omeprazole, esomeprazole). Caution with concomitant other drugs that increase risk of bleeding (eg, NSAIDs, warfarin, SSRI, SNRI). Avoid concomitant repaglinide; if unavoidable, initiate repaglinide at 0.5mg before each meal; max 4mg/day; monitor glucose frequently.

Pharmacological Class:

P2Y12 platelet inhibitor (thienopyridine).

Adverse Reactions:

Bleeding (may be fatal), epistaxis, hematuria, bruising, ulcers, rash; hypersensitivity reactions, thrombotic thrombocytopenic purpura.

How Supplied:

Tabs 75mg—30, 90, 100, 500; 300mg—30, 100

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