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Phenylephrine HCl Injection
Anesthetics
CHF and arrhythmias
Hypotension
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Drug Name:

Phenylephrine HCl Injection Rx

Generic Name and Formulations:
Phenylephrine HCl 10mg/mL; soln for IV, IM, or SC inj; contains sulfites.

Company:
Teva Pharmaceuticals

Therapeutic Use:

Indications for Phenylephrine HCl Injection:

Prolongation of spinal anesthesia. Vasoconstrictor in regional analgesia.

Adult:

Prolongation of spinal anesthesia: add 2–5mg into anesthetic solution. Vasoconstrictor for regional analgesia: add 1mg to every 20mL (1:20,000) of local anesthetic solution.

Children:

Not recommended.

Contraindications:

Severe hypertension. Ventricular tachycardia.

Warnings/Precautions:

Cardiovascular disease. Hypertension. Thyroid disease. Asthma. Sulfite sensitivity. Elderly. Pregnancy (Cat.C). Labor & delivery. Nursing mothers.

Interactions:

Potentiated by oxytocic drugs, tricyclic antidepressants, or MAOIs. Caution with halothane anesthesia.

Pharmacological Class:

Sympathomimetic.

Adverse Reactions:

Headache, reflex bradycardia, excitability, restlessness: rare: arrhythmias.

How Supplied:

Vial 10mg/mL (1mL, 5mL)—25

Indications for Phenylephrine HCl Injection:

Paroxysmal supraventricular tachycardia.

Adult:

Give by rapid IV inj within 20–30secs. Initial max dose: 0.5mg, subsequent doses not to exceed preceding dose by 0.1–0.2mg; max: 1mg.

Children:

Not recommended.

Contraindications:

Severe hypertension. Ventricular tachycardia.

Warnings/Precautions:

Cardiovascular disease. Hypertension. Thyroid disease. Asthma. Sulfite sensitivity. Elderly. Pregnancy (Cat.C). Labor & delivery. Nursing mothers.

Interactions:

Potentiated by oxytocic drugs, tricyclic antidepressants, or MAOIs. Caution with halothane anesthesia.

Pharmacological Class:

Sympathomimetic.

Adverse Reactions:

Headache, reflex bradycardia, excitability, restlessness: rare: arrhythmias.

How Supplied:

Vial 10mg/mL (1mL, 5mL)—25

Indications for Phenylephrine HCl Injection:

To maintain adequate blood pressure during spinal and inhalation anesthesia. Vascular failure in shock, shock-like states and drug-induced hypotension or hypersensitivity.

Adult:

Spinal anesthesia hypotension: treatment or prophylaxis: 2–3mg SC or IM 3–4 minutes prior to spinal anesthesia; hypotensive crisis: initially 0.2mg by IV inj, subsequent doses not to exceed preceding dose by 0.1–0.2mg; max: 0.5mg/dose. Mild or moderate hypotension: SC or IM: usually 2–5mg; initial max dose: 5mg. Range: 1–10mg; IV: usually 0.2mg; initial max dose: 0.5mg. Range: 0.1–0.5mg. Do not repeat injections more often than every 10–15mins. Shock and drug-induced: initially 10mg by continuous IV infusion, if non-responsive, add additional 10mg (or more) into infusion bottle. See literature.

Children:

Spinal anesthesia hypotension: 0.5–1mg/25lbs body weight by SC or IM.

Contraindications:

Severe hypertension. Ventricular tachycardia.

Warnings/Precautions:

Cardiovascular disease. Hypertension. Thyroid disease. Asthma. Sulfite sensitivity. Elderly. Pregnancy (Cat.C). Labor & delivery. Nursing mothers.

Interactions:

Potentiated by oxytocic drugs, tricyclic antidepressants, or MAOIs. Caution with halothane anesthesia.

Pharmacological Class:

Sympathomimetic.

Adverse Reactions:

Headache, reflex bradycardia, excitability, restlessness: rare: arrhythmias.

How Supplied:

Vial 10mg/mL (1mL, 5mL)—25

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