Personalized Medicine

Personalized Medicine Approach Not Straightforward in Glioblastoma

Personalized Medicine Approach Not Straightforward in Glioblastoma

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The role of antiangiogenic agents continues to evolve in the treatment of CNS cancers, attendees were told in a poster discussion session at the American Society of Clinical Oncology (ASCO) 2016 Annual Meeting.

Personalized Drug Screen Aids Treatment Selection for Patients with Multiple Myeloma

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A personalized testing method may quickly and more accurately predict the effectiveness of a treatment for multiple myeloma in individual patients. The process may also aid patients with leukemia or lymphoma.

For Best Responses, Use Therapeutic Drug Monitoring to Individualize Daily Imatinib

For Best Responses, Use Therapeutic Drug Monitoring to Individualize Daily Imatinib

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Research indicates that adjustment of imatinib doses based on therapeutic drug monitoring can result in higher rates of major molecular response in patients with newly diagnosed chronic myeloid leukemia (CML) in the chronic phase.

Long-term remissions achieved in first personalized cell therapy trial

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Eight of 14 patients in the first clinical trial of personalized cellular therapy for chronic lymphocytic leukemia (CLL) responded to the therapy, with some complete remissions continuing beyond 4.5 years.

Researchers develop a more efficient process for identifying personalized bladder cancer treatment

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Researchers developed a way to personalize treatments for aggressive bladder cancer. Taking bladder tumors from individual patients, identifying actionable mutations, and grafting the tumors into mice, researchers were able to simultaneously test multiple therapies in the tumor models.

Landmark basket study is changing how drug trials are conducted

Landmark basket study is changing how drug trials are conducted

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Results are in from the first published basket study, a new form of clinical trial design that explores responses to drugs based on the specific mutations in patients' tumors rather than where their cancer originated.

Race and institutional factors play important roles in pharmacogenomics trial participation

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Researchers examined patient participation in the genomic analysis portion of clinical trials.

Treating colon cancer through personalized medicine

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An increased understanding of how a certain tumor suppressor molecule works to prevent tumor growth may open the door to a personalized treatment approach for colon cancer.

Personal genome diagnostics study shows limitations of tumor-only sequencing for cancer

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New research indicates that many genetic alterations identified using tumor-only sequencing are not actually associated with the cancer, but instead reflect inherited germline mutations already present in the normal cells of the person.

Investigational personalized cellular therapy tolerated well by patients

Investigational personalized cellular therapy tolerated well by patients

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An early stage trial for mesothelioma and pancreatic and ovarian cancers has explored utilizing a patient's own immune cells, genetically modified to target tumors.

International study suggests precision medicine has potential in adrenal cancer

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Adrenal cancer is among the more rare and aggressive forms of cancer, but new research indicates the possibility of personalized treatment.

Precision medication is effective for subset of adrenal cancer patients

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A subset of adrenal cancer patients responded well to drug treatment in a phase 3 trial, giving some hope for addressing this aggressive form of cancer.

3D printing offers innovative method for delivering medication

3D printing offers innovative method for delivering medication

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The use of 3D printing to construct devices of varied sizes and shapes could become a powerful tool in customizing interventional radiology treatments to individual patient needs.

Tumor reproduction in animal models may improve personalized therapy and relapse risk

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New animal models have been developed that allow for improved parallel tumor progression and can help clinicians predict relapses and treatment effectiveness.

Investigational cellular therapy promising for pediatric ALL and for lymphoma

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Pediatric patients with acute lymphoblastic leukemia (ALL) showed a 90% response rate from the first trials testing an investigational personalized cellular therapy known as CTL019.

Possibilities revealed for personalized vaccines in cancer

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The possibilities for personalized vaccines in all types of cancer were explored at the European Society for Medical Oncology Symposium on Immuno-Oncology 2014.

Personalized genetic test predicts recurrence risk for prostate cancer

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A genetic test has been developed to identify which men are at higher risk for prostate cancer recurrence after localized treatment with surgery or radiotherapy.

Genetic profile and potential drug susceptibility of breast cancer cells revealed by CTCs

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Circulating tumor cells captured with a microchip-based device can be cultured to establish cell lines for genetic analysis and drug testing.

Scientists bring personalized medicine for breast cancer one step closer

Scientists bring personalized medicine for breast cancer one step closer

The era of personalized medicine for breast cancer may be just around the corner, thanks to recent advances by USC Stem Cell researcher Min Yu and scientists at Massachusetts General Hospital and Harvard Medical School.

Autologous cancer vaccine extends survival in patients with newly diagnosed GBM

Autologous cancer vaccine extends survival in patients with newly diagnosed GBM

Final results from a phase 2 study show that adding Prophage autologous cancer vaccine to the standard-of-care treatment for newly diagnosed GBM improves survival.

Process personalizes treatment for lung cancer patients

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Researchers have developed a process to analyze mutated genes in lung adenocarcinoma to help better select personalized treatment options for patients.

Molecular tumor board helps in advanced cancer cases

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With accelerating development of personalized cancer treatments matched to a patient's DNA sequencing, proponents of these treatments say frontline physicians increasingly need help finding the best individualized therapy.

Immunogenic mutations in tumor genomes tied to increased survival

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In a new study, researchers examined the largest collection of tumor samples to date to predict patient-specific tumor mutations that may activate the patient's immune system, paving the way for more successful, personalized cancer immunotherapy.

Genes may predict the need for further cancer treatments

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A new predictive tool is being developed that could help patients with breast cancer and certain lung cancers decide whether follow-up treatments are likely to help.

Germline EGFR T790M mutation indicates a high risk for familial NSCLC regardless of smoking

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Two studies provide new insight into a germline epidermal growth factor receptor T790M mutation in familial non-small cell lung cancer, and suggest the need for tailored approaches for early detection and treatment.

Canine DNA aids in developing new therapies for human cancers

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Using genomic analysis to study cancer in dogs can help develop new therapies for humans with cancer, according to a proof-of-concept study.

Novel biologic drug holds promise for individualized ovarian cancer treatment

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Researchers have developed a biologic drug that would prevent the production of a protein known to allow ovarian cancer cells to grow aggressively while being resistant to chemotherapy.

Personalized medicine is the ideal way to treat cancer

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Assessing the route to cancer on a case-by-case basis might make more sense than basing a patient's cancer treatment on commonly disrupted genes and pathways, according to a new study.

Survival improved with personalized tumor vaccines added to IL-2 for melanoma

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Combining high-dose interleukin-2 and personalized vaccines to activate patients' immune systems improves survival of metastatic melanoma even more than IL-2 alone.

Personalized vaccine for most lethal type of brain tumor shows promise

Personalized vaccine for most lethal type of brain tumor shows promise

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Patients with recurrent GBM treated with an experimental vaccine made from the patient's own resected tumor tissue showed an improved survival compared with historical patients who received the standard of care alone, according to an analysis of a phase 2 trial of this vaccine.

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