Peptide Level Ups Diagnosis of Heart Failure in Primary Care

Share this article:
Peptide Level Ups Diagnosis of Heart Failure in Primary Care
Peptide Level Ups Diagnosis of Heart Failure in Primary Care

(HealthDay News) – For patients presenting with dyspnea, the additional measurement of B-type natriuretic peptide (BNP) levels increases the certainty of diagnosis of heart failure and accelerates initiation of appropriate treatment, but does not reduce medical costs, according to a study published online May 2 in the Journal of Internal Medicine.

To evaluate the additional use of BNP levels to diagnose heart failure in the primary care setting, Emanuel Burri, MD, of the University Hospital Basel in Switzerland, and colleagues conducted a randomized, controlled trial involving 323 patients with dyspnea treated by 29 primary care physicians in Germany and Switzerland. Participants were assigned in a 1:1 ratio to receive point-of-care measurement of BNP or standard assessment without BNP.

The researchers found that 34 percent of patients presenting with dyspnea to their primary care physicians were ultimately diagnosed with heart failure. Compared with standard assessment, addition of BNP measurement did not decrease the number of hospitalizations, functional status, or total medical costs at three months. However, the additional use of BNP significantly increased diagnostic certainty, indicated by a reduced need for further diagnostic work-up (33% vs. 45%; P=0.02), and sped up the initiation of appropriate treatment (13 vs. 25 days; P=0.01).

"The measurement of BNP levels in primary care did not reduce total medical cost, but improved some of the secondary endpoints including an increase in diagnostic certainty and more rapid initiation of appropriate treatment," the authors write.

One of the authors disclosed financial ties to the pharmaceutical industry.

Abstract
Full Text (subscription or payment may be required)

This article originally appeared here.
Share this article:
You must be a registered member of ONA to post a comment.

Sign Up for Free e-newsletters

April Contest: Win a Pebble Watch

Start the contest today

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs