Pediatric Oncology

Current, Emerging Systemic and Targeted Therapies for Pediatric Leukemia: A Review

Current, Emerging Systemic and Targeted Therapies for Pediatric Leukemia: A Review

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In this review, investigators discuss current and emerging treatments for acute lymphocytic leukemia and acute myeloid leukemia in pediatric patients.

Cancer Risk Not Increased by Childhood Exposure to Diagnostic Radiation

Cancer Risk Not Increased by Childhood Exposure to Diagnostic Radiation

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Risk of developing cancer as a result of childhood exposure to medical imaging radiation is not increased in children or adults, a new study reports.

Screening Recommendations for Children with Common Cancer Predisposition Syndromes

Screening Recommendations for Children with Common Cancer Predisposition Syndromes

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The Pediatric Cancer Working Group of the AACR released its first consensus screening guidelines for children with common cancer predisposition syndromes.

Self-Reports on Adverse Effects From Younger Patients Are Reliable, Accurate

Self-Reports on Adverse Effects From Younger Patients Are Reliable, Accurate

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Children and adolescent patients with cancer are able to accurately report subjective adverse events (AEs) they experience during their cancer treatment, and they are willing to do so.

Checkpoint Inhibitors Appear Safe for Pediatric Cancer Patients

Checkpoint Inhibitors Appear Safe for Pediatric Cancer Patients

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The medications so far show little efficacy in children with cancer, but new studies may provide clues to how to change this, pediatric oncologist says.

Pediatric Acute Lymphoblastic Leukemia Extramedullary Relapse Responds to CAR-T

Pediatric Acute Lymphoblastic Leukemia Extramedullary Relapse Responds to CAR-T

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Children with extramedullary relapse of CD19+ acute lymphoblastic leukemia experienced a potent and durable response to the immunotherapy.

Videos, Movies Eliminates Need for Anesthesia During Pediatric Radiation Therapy

Videos, Movies Eliminates Need for Anesthesia During Pediatric Radiation Therapy

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Pediatric patients are better able to tolerate radiation therapy without anesthesia when video movies are projected on the inside of the machine during treatment.

Oncolytic HSV-1 Promising in Refractory Incurable Non-CNS Solid Tumors in Pediatric Patients

Oncolytic HSV-1 Promising in Refractory Incurable Non-CNS Solid Tumors in Pediatric Patients

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Oncolytic variants of the HSV-1 have successfully treated melanoma, glioma, and other cancers in adults; in this study, researchers test the effectiveness of an oncolytic HSV-1 in pediatric patients.

Social Functioning Scores for Young Cancer Survivors Remain Lower Than Their Peers

Social Functioning Scores for Young Cancer Survivors Remain Lower Than Their Peers

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AYAs continue to report lower social functioning scores than their peers 2 years after diagnosis.

Dance/Movement Therapy: A Unique and Enjoyable Approach to Support Children with Cancer

Dance/Movement Therapy: A Unique and Enjoyable Approach to Support Children with Cancer

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Dr Lori Baudino, a clinical psychologist and dance/movement therapist, discusses a program that helps children with cancer cope with their disease and treatment, and learn to be children again.

Pediatric Papillary Thyroid Cancer: Current Management Challenges

Pediatric Papillary Thyroid Cancer: Current Management Challenges

[OncoTargets and Therapy] This research presents an overview of patient and disease management in pediatric pediatric papillary thyroid (PTC) patients.

New Oral Therapy Shows Promise Against Neurofibromatosis Type 1-Related Plexiform Neurofibromatomas in Children

New Oral Therapy Shows Promise Against Neurofibromatosis Type 1-Related Plexiform Neurofibromatomas in Children

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In this clinical trial, researchers determined the safety and efficacy of selumetinib, a selective MEK inhibitor, in children with NF1-related neurofibromas.

Pediatric Patients Continue to Experience High-Intensity EOL Care

Pediatric Patients Continue to Experience High-Intensity EOL Care

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Studies of end-of-life (EOL) care for pediatric patients have been limited to single institutions or lacked detailed clinical data. Therefore, researchers conducted a retrospective cohort study to examine predictor of, and trends in, high-intensity EOL care in this patient population.

Drug Prevents Heart Damage in Pediatric Patients Receiving Chemotherapy

Drug Prevents Heart Damage in Pediatric Patients Receiving Chemotherapy

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Dexrazoxane has cardioprotective properties that can prevent long-term cardiotoxicity in pediatric patients receiving chemotherapy, according to a review of the medical literature on cardiotoxic effects of anthracycline treatment.

Costs, Hospital Stays for BSIs Significant in Pediatric Oncology Outpatient Setting

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Ambulatory bloodstream infections in pediatric oncology and stem cell transplant patients result in significant health care charges and extended hospital admissions.

MASCC Updates Guidelines for CINV Prevention in Children

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The Multinational Association of Supportive Care in Cancer and the European Society for Medical Oncology updated their 2009 consensus recommendations for the prevention of acute CINV in pediatric patients with cancer.

Telomere Length Predicts Risk for Delayed Recovery in Pediatric Patients With AML

Telomere Length Predicts Risk for Delayed Recovery in Pediatric Patients With AML

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Telomere length is predictive for determining which children treated for AML are at highest risk for delayed recovery, a finding that may have significant implications for treatment-related morbidity and mortality.

Higher Concentrations of Methotrexate for Pediatric Leukemia Affect Long-Term Cognitive Processes

Higher Concentrations of Methotrexate for Pediatric Leukemia Affect Long-Term Cognitive Processes

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Pediatric patients with ALL treated with methotrexate can experience challenges with mental flexibility and organization compared with expectations from the general population.

New Therapy Holds Promise for Patients With Ewing Sarcoma

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Two new compounds suppress tumor growth in cell culture and mouse xenograft models of Ewing sarcoma, a rare pediatric cancer. These 2 compounds are similar to mithramycin, also known as picamycin, a drug no longer manufactured due to its toxicity.

Eye Motor Skills Damaged in Survivors of Childhood Cancer

Eye Motor Skills Damaged in Survivors of Childhood Cancer

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Chemotherapy agents commonly used to treat childhood cancer impair eyesight in a way that indicates an impact on the CNS. The damage occurs to the patient's eye motor skills.

Early Lineage T Cells Are Better for Immunotherapy in Pediatric Patients With ALL and Lymphoma

Early Lineage T Cells Are Better for Immunotherapy in Pediatric Patients With ALL and Lymphoma

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Outcomes from a novel personalized cell therapy may be improved if specific subtypes of T cells are selected to attack diseases such as acute lymphoblastic leukemia and lymphoma.

Standards Established for Psychosocial Care of Children With Cancer and Their Families

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A group of pediatric oncology psychosocial experts developed evidence-based standards for the care of children with cancer and their families.

Criteria Described to Allocate Scarce Drugs for Pediatric Oncology Patients

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A framework has been issued to avoid waste and guide difficult prioritization decisions among children who need scarce life-saving chemotherapy treatment.

ALK-positive anaplastic large cell lymphoma with prominent bone involvement in a 13-year-old boy

ALK-positive anaplastic large cell lymphoma with prominent bone involvement in a 13-year-old boy

[OncoTargets and Therapy] Anaplastic large cell lymphoma (ALCL) frequently involves the bone marrow, but primary or secondary involvement to the bone is rare. This article examines a case of anaplastic lymphoma kinase positive ALCL with prominent bone involvement in a young boy.

Inferior Outcomes for African Americans With Pediatric Hodgkin Lymphoma

Inferior Outcomes for African Americans With Pediatric Hodgkin Lymphoma

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African-American pediatric patients with Hodgkin lymphoma still display a considerable survival disparity when compared to their white and Hispanic peers.

Basic Research Data Pivotal for First FDA Approval of Immunotherapy for Pediatric Cancer

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New research has helped influence the FDA's decision to approve the first immunotherapy for pediatric patients.

Risk of Metabolic Syndrome Increased in Survivors of Childhood Cancer

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Early cardiovascular events are a risk for survivors of childhood cancer, according to researchers who also advocate for a unified definition of pediatric metabolic syndrome.

The Pediatric Home Care/Expenditure Classification Model (P/ECM): A Home Care Case-Mix Model for Children Facing Special Health Care Challenges

The Pediatric Home Care/Expenditure Classification Model (P/ECM): A Home Care Case-Mix Model for Children Facing Special Health Care Challenges

[Health Services Insights] This research explores the use of case-mix payment systems for younger patients with cancer.

Novel Drug Effective in Treatment Resistant Pediatric Neuroblastoma

Novel Drug Effective in Treatment Resistant Pediatric Neuroblastoma

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Researchers in pediatric oncology identified a powerful new drug with unparalleled strength against neuroblastomas that resist treatment with crizotinib.

Therapy Dogs and Children With Cancer

Therapy Dogs and Children With Cancer

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Researchers hope to prove the positive effects of the use of therapy dogs in pediatric oncology.

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