Pediatric Oncology

Pediatric Patients Continue to Experience High-Intensity EOL Care

Pediatric Patients Continue to Experience High-Intensity EOL Care

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Studies of end-of-life (EOL) care for pediatric patients have been limited to single institutions or lacked detailed clinical data. Therefore, researchers conducted a retrospective cohort study to examine predictor of, and trends in, high-intensity EOL care in this patient population.

Drug Prevents Heart Damage in Pediatric Patients Receiving Chemotherapy

Drug Prevents Heart Damage in Pediatric Patients Receiving Chemotherapy

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Dexrazoxane has cardioprotective properties that can prevent long-term cardiotoxicity in pediatric patients receiving chemotherapy, according to a review of the medical literature on cardiotoxic effects of anthracycline treatment.

Costs, Hospital Stays for BSIs Significant in Pediatric Oncology Outpatient Setting

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Ambulatory bloodstream infections in pediatric oncology and stem cell transplant patients result in significant health care charges and extended hospital admissions.

MASCC Updates Guidelines for CINV Prevention in Children

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The Multinational Association of Supportive Care in Cancer and the European Society for Medical Oncology updated their 2009 consensus recommendations for the prevention of acute CINV in pediatric patients with cancer.

Telomere Length Predicts Risk for Delayed Recovery in Pediatric Patients With AML

Telomere Length Predicts Risk for Delayed Recovery in Pediatric Patients With AML

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Telomere length is predictive for determining which children treated for AML are at highest risk for delayed recovery, a finding that may have significant implications for treatment-related morbidity and mortality.

Higher Concentrations of Methotrexate for Pediatric Leukemia Affect Long-Term Cognitive Processes

Higher Concentrations of Methotrexate for Pediatric Leukemia Affect Long-Term Cognitive Processes

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Pediatric patients with ALL treated with methotrexate can experience challenges with mental flexibility and organization compared with expectations from the general population.

New Therapy Holds Promise for Patients With Ewing Sarcoma

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Two new compounds suppress tumor growth in cell culture and mouse xenograft models of Ewing sarcoma, a rare pediatric cancer. These 2 compounds are similar to mithramycin, also known as picamycin, a drug no longer manufactured due to its toxicity.

Eye Motor Skills Damaged in Survivors of Childhood Cancer

Eye Motor Skills Damaged in Survivors of Childhood Cancer

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Chemotherapy agents commonly used to treat childhood cancer impair eyesight in a way that indicates an impact on the CNS. The damage occurs to the patient's eye motor skills.

Early Lineage T Cells Are Better for Immunotherapy in Pediatric Patients With ALL and Lymphoma

Early Lineage T Cells Are Better for Immunotherapy in Pediatric Patients With ALL and Lymphoma

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Outcomes from a novel personalized cell therapy may be improved if specific subtypes of T cells are selected to attack diseases such as acute lymphoblastic leukemia and lymphoma.

Standards Established for Psychosocial Care of Children With Cancer and Their Families

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A group of pediatric oncology psychosocial experts developed evidence-based standards for the care of children with cancer and their families.

Criteria Described to Allocate Scarce Drugs for Pediatric Oncology Patients

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A framework has been issued to avoid waste and guide difficult prioritization decisions among children who need scarce life-saving chemotherapy treatment.

ALK-positive anaplastic large cell lymphoma with prominent bone involvement in a 13-year-old boy

ALK-positive anaplastic large cell lymphoma with prominent bone involvement in a 13-year-old boy

[OncoTargets and Therapy] Anaplastic large cell lymphoma (ALCL) frequently involves the bone marrow, but primary or secondary involvement to the bone is rare. This article examines a case of anaplastic lymphoma kinase positive ALCL with prominent bone involvement in a young boy.

Inferior Outcomes for African Americans With Pediatric Hodgkin Lymphoma

Inferior Outcomes for African Americans With Pediatric Hodgkin Lymphoma

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African-American pediatric patients with Hodgkin lymphoma still display a considerable survival disparity when compared to their white and Hispanic peers.

Basic Research Data Pivotal for First FDA Approval of Immunotherapy for Pediatric Cancer

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New research has helped influence the FDA's decision to approve the first immunotherapy for pediatric patients.

Risk of Metabolic Syndrome Increased in Survivors of Childhood Cancer

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Early cardiovascular events are a risk for survivors of childhood cancer, according to researchers who also advocate for a unified definition of pediatric metabolic syndrome.

The Pediatric Home Care/Expenditure Classification Model (P/ECM): A Home Care Case-Mix Model for Children Facing Special Health Care Challenges

The Pediatric Home Care/Expenditure Classification Model (P/ECM): A Home Care Case-Mix Model for Children Facing Special Health Care Challenges

[Health Services Insights] This research explores the use of case-mix payment systems for younger patients with cancer.

Novel Drug Effective in Treatment Resistant Pediatric Neuroblastoma

Novel Drug Effective in Treatment Resistant Pediatric Neuroblastoma

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Researchers in pediatric oncology identified a powerful new drug with unparalleled strength against neuroblastomas that resist treatment with crizotinib.

Therapy Dogs and Children With Cancer

Therapy Dogs and Children With Cancer

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Researchers hope to prove the positive effects of the use of therapy dogs in pediatric oncology.

Children With Cancer May Have Genetic Predisposition Even Without a Family History of Disease

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Comprehensive genomic screening may be warranted for all pediatric patients with cancer, not just those with a family history of cancer, according to results of a detailed analysis of germline mutations in cancer predisposition genes.

Ethnic, Racial, and Socioeconomic Disparities in Retinoblastoma in Children

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Ethnic, racial, and socioeconomic disparities appear to exist among children with retinoblastoma, a once uniformly fatal but now treatable eye cancer. Those disparities are associated with greater risks for advanced disease and undergoing removal of the eye.

Some Pediatric Patients With Wilms' Tumor Can Avoid Doxorubicin

Some Pediatric Patients With Wilms' Tumor Can Avoid Doxorubicin

Children with Wilm's tumor who are at low risk for relapse can be given less intensive treatment by omitting doxorubicin from the treatment regimen.

Large increase in pediatric patients treated with proton therapy

A new nationwide survey has indicated that the number of pediatric cancer patients being treated with proton radiation therapy is on the rise.

Providing psychosocial care when the patient is a child

Providing psychosocial care when the patient is a child

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Use of straightforward, age-appropriate language is essential to communicating with pediatric oncology patients about their cancer and treatments, and gaining their trust in the medical team.

Adapting Pediatric Cancer Treatments to Spur Early Detection and Reduce Late Effects

Adapting Pediatric Cancer Treatments to Spur Early Detection and Reduce Late Effects

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Modifying pediatric cancer treatments may reduce occurrence of late effects and promoting early detection, indicated data from a 5-year analysis of childhood cancers survivors presented at ASCO 2015.

High radiotherapy dose improves prospects for children with brain cancer

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Increasing the dose of radiotherapy given to children with an intracranial ependymoma can significantly improve their survival.

Children's Oncology Group Examines National Educational Practices in Pediatric Patients

Children's Oncology Group Examines National Educational Practices in Pediatric Patients

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Premier study examines current delivery of patient/family education to pediatric patients with newly diagnosed cancer.

Measuring treatment response is essential to guiding leukemia treatment

Measuring treatment response is essential to guiding leukemia treatment

A measurement of the concentration of leukemia cells in patient bone marrow during the first 46 days of chemotherapy may allow for better matching of patients to the optimal intensity of chemotherapy.

Audio therapy for pediatric postoperative pain

Audio therapy for pediatric postoperative pain

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Listening to music or audiobooks has a profound impact on postoperative pain perception in children. The benefit is increased when the patients are allowed to choose their own music or stories.

Young adults with acute lymphoblastic leukemia (ALL) benefit from therapies developed for children

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There is increasing evidence that adolescent and young adult patients with acute lymphoblastic leukemia (ALL) tend to fare better when treated with high-intensity pediatric protocols than standard adult regimens.

Benefits of T cell therapy for children with relapsed leukemia are ongoing

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An innovative cell therapy against a highly aggressive form of acute lymphoblastic leukemia (ALL) continues to show highly promising results in children treated in a pilot study. At 1 month after treatment, 92% of the 39 children receiving bioengineered T cells had no evidence of cancer.

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