Pediatric Cancer

Pediatric Hepatocellular Carcinoma: Challenges and Solutions

Pediatric Hepatocellular Carcinoma: Challenges and Solutions

[Journal of Hepatocellular Carcinoma] This research examines the medical challenges presented by pediatric hepatocellular carcinoma (HCC).

Pediatric Patients, Parents Overreport Adherence to ALL Medication Regimen

Pediatric Patients, Parents Overreport Adherence to ALL Medication Regimen

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Pediatric patients and their parents tend to overestimate adherence to anticancer medicine regimen.

Researchers Discover Prognostic Genetic Subgroups of a High-Risk Pediatric Leukemia

Researchers Discover Prognostic Genetic Subgroups of a High-Risk Pediatric Leukemia

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Research from St Jude Children's Research Hospital reveals that acute megakaryoblastic leukemia can be divided into several subgroups with varying prognoses, particularly for children without Down syndrome.

Study Suggest New Treatment Approaches for High-Risk Pediatric Leukemia

Study Suggest New Treatment Approaches for High-Risk Pediatric Leukemia

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Three specific genetic alterations may help identify pediatric patients with AMKL at high risk who may benefit from allogeneic stem cell transplants.

Pediatric Papillary Thyroid Cancer: Current Management Challenges

Pediatric Papillary Thyroid Cancer: Current Management Challenges

[OncoTargets and Therapy] This research presents an overview of patient and disease management in pediatric pediatric papillary thyroid (PTC) patients.

New Oral Therapy Shows Promise Against Neurofibromatosis Type 1-Related Plexiform Neurofibromatomas in Children

New Oral Therapy Shows Promise Against Neurofibromatosis Type 1-Related Plexiform Neurofibromatomas in Children

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In this clinical trial, researchers determined the safety and efficacy of selumetinib, a selective MEK inhibitor, in children with NF1-related neurofibromas.

Prenatal Herpes Virus Infection May Increase Childhood Leukemia Risk

Prenatal Herpes Virus Infection May Increase Childhood Leukemia Risk

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Study results indicate that herpetic cytomegalovirus infection prior to birth subjects the child to increased odds of developing pediatric acute lymphoblastic leukemia.

AYA Cancer Survivors More Likely to Have Mental Distress Than Healthy Individuals

AYA Cancer Survivors More Likely to Have Mental Distress Than Healthy Individuals

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Using the Kessler nonspecific mental/psychological distress scale, investigators examined whether AYA cancer survivor experienced greater mental distress and assessed their access to mental health care.

Pediatric Patients Continue to Experience High-Intensity EOL Care

Pediatric Patients Continue to Experience High-Intensity EOL Care

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Studies of end-of-life (EOL) care for pediatric patients have been limited to single institutions or lacked detailed clinical data. Therefore, researchers conducted a retrospective cohort study to examine predictor of, and trends in, high-intensity EOL care in this patient population.

Postop RT Deferral Associated With Worse Survival in Children With Medulloblastoma

Postop RT Deferral Associated With Worse Survival in Children With Medulloblastoma

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Despite the use of adjuvant chemotherapy, deferral of postoperative radiotherapy is associated with worse survival in pediatric patients with medulloblastoma.

Experimental Targeted Therapy Succeeds in Rare Pediatric Cancer

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The experimental treatment LOXO-101 led to remarkable improvement for a 20-month-old girl whose rare pediatric cancer did not respond to surgery or chemotherapy.

Predicting Seizure Incidence and Frequency in Survivors of Pediatric Brain Tumors

Predicting Seizure Incidence and Frequency in Survivors of Pediatric Brain Tumors

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Researchers at Dana-Farber/Boston Children's Cancer and Blood Disorders Center sought to assess the effects of treatment for brain tumors in children over 10 years of follow-up.

Genetic landscape can impact treatment for children with rare, aggressive cancer

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Precision medicine may help doctors determine the best treatment options for children with rare, aggressive, and advanced cancer. Information from a patient's entire genome helped personalize treatment options for children with cancer, according to a new study.

Some Pediatric Patients With Wilms' Tumor Can Avoid Doxorubicin

Some Pediatric Patients With Wilms' Tumor Can Avoid Doxorubicin

Children with Wilm's tumor who are at low risk for relapse can be given less intensive treatment by omitting doxorubicin from the treatment regimen.

Improvements to mental health services for parents who lost a child to cancer are needed

Improvements to mental health services for parents who lost a child to cancer are needed

Parents of children with cancer appear to need, want, and often access bereavement mental health services after the death of their child.

Adapting Pediatric Cancer Treatments to Spur Early Detection and Reduce Late Effects

Adapting Pediatric Cancer Treatments to Spur Early Detection and Reduce Late Effects

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Modifying pediatric cancer treatments may reduce occurrence of late effects and promoting early detection, indicated data from a 5-year analysis of childhood cancers survivors presented at ASCO 2015.

Pediatric patients treated with proton therapy on the rise

Pediatric patients treated with proton therapy on the rise

There has been a 36% increase in the number of pediatric patients who are being treated with proton therapy for cancer.

Possible treatment identified for lethal pediatric brain cancer

Possible treatment identified for lethal pediatric brain cancer

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Gene-regulating drugs may be effective at treating diffuse intrinsic pontine gliomas (DIPG), research indicates.

Childhood cancer treatments may increase obesity risk later

Childhood cancer treatments may increase obesity risk later

Certain treatments used to treat children with cancer may increase their risk for obesity later in life.

Higher-than-expected pediatric cancer rates identified in two Florida areas

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A series of statistical analyses have identified both the Miami metro area and an area west of the Everglades as having unusually high rates of pediatric cancers.

Children with advanced cancer experience high symptom distress

Children with advanced cancer experience high symptom distress

A recent study examined symptom distress in children living with advanced cancer, and found that a majority experience high symptom distress.

Model Details Challenges of Educating Staff in Pediatric, Adult Oncology Patient Care

Model Details Challenges of Educating Staff in Pediatric, Adult Oncology Patient Care

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A model was created to address the challenges of educating staff that care for both adult and pediatric patients.

Program Improves Transitioning Young Cancer Survivors to Adult Survivorship Care

Program Improves Transitioning Young Cancer Survivors to Adult Survivorship Care

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A program improves the transition from pediatric to adult survivorship care has had a 100% increase in referrals.

Treatment guidelines for pediatric Hodgkin lymphoma issued by the International Lymphoma Radiation Oncology Group (ILROG)

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The International Lymphoma Radiation Oncology Group (ILROG) has issued a guideline outlining use of 3-D computed tomography (CT)-based radiation therapy planning.

Prevalence of childhood cancer survivors increasing

Prevalence of childhood cancer survivors increasing

Prevalence of childhood cancer survivors is increasing, and those who survived at least 5 years beyond diagnosis have at least one comorbidity.

Breastfeeding may decrease risk of pediatric acute lymphoblastic leukemia

Breastfeeding may decrease risk of pediatric acute lymphoblastic leukemia

Breastfeeding a child may reduce that child's risk of developing pediatric acute lymphoblastic leukemia (ALL).

Gene regulatory path revealed as target for therapy of aggressive pediatric brain cancer

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Working with cells taken from children with a rare form of brain cancer, scientists have identified a genetic pathway that may spur cancer cell growth and resistance to anticancer treatment.

Sun damage predisposes pediatric patients to melanoma

Sun damage predisposes pediatric patients to melanoma

Melanoma in some adolescent and adult patients involve many of the same genetic mutations and would likely respond to the same treatment.

Adult survivors of pediatric cancer who underwent brain irradiation at risk for hormone deficiencies

Adult survivors of pediatric cancer who underwent brain irradiation at risk for hormone deficiencies

Adult survivors of pediatric cancer are at risk for developing pituitary hormone deficiencies that may worsen their health and quality of life.

Group finds new method for identifying most aggressive childhood cancers

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A new method involving the study of genetic micro-variation, rather than the presence of individual mutations, could help identify malignant tumors in children.

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