Patient Outcomes

Capecitabine does not improve survival in elderly patients with early stage breast cancer

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In elderly patients with moderate- to high-risk early stage breast cancer for whom standard chemotherapy is too toxic, capecitabine did not improve outcomes when tested as monotherapy, according to recent data.

Key discovery in understanding successes and failures of immunotherapy

Key discovery in understanding successes and failures of immunotherapy

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A key discovery has advanced the understanding of why some patients respond to ipilimumab, an immunotherapy drug, whereas others show less response.

Galeterone active in one form of castration-resistant prostate cancer

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The anticancer drug galeterone has proved successful in lowering prostate-specific antigen levels in men with castration-resistant prostate cancer (CRPC).

Researchers identify biological indicator of response to new ovarian cancer drug

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A method to determine which patients with ovarian cancer are more likely to respond well to the new anticancer drug rucaparib has been discovered.

Financial incentives double quit rates among smokers

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Employing financial incentives to encourage smokers to reduce cigarette use can be a successful ploy.

Women with serious mental illness are less likely to receive cancer screenings

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Women with symptoms of serious mental illness are significantly less likely to receive the three routine cancer screenings of Pap tests, mammography, and clinical breast examinations than women in the general population.

Ovarian cancer patients may benefit from pelvic radiotherapy

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Ovarian clear cell adenocarcinoma (CCA), a rare and aggressive form of ovarian cancer, may be treated by employing pelvic radiotherapy (RT).

Tumor-analysis technology speeds treatment decisions for colorectal cancer

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A novel medical-imaging technology, TexRAD, which analyzes the texture of tumors, has been shown in trials to enable early diagnosis of colorectal cancer in patients not responding to the standard cancer therapy better than other available tumor markers.

Conventional therapies are less effective in prostate cancer with BRCA mutations

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Prostate cancer patients with hereditary mutations in the BRCA genes do not respond as well to conventional treatment such as surgery and radiotherapy, and they have a lower survival rate than patients who do not have these genetic mutations.

Chemotherapy after radiation slows progression of low-grade gliomas

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A chemotherapy regimen of procarbazine, lomustine (CCNU), and vincristine (PCV) administered after radiation therapy improved both progression-free survival and overall survival in adults with low-grade gliomas.

Cancer-killing virus and doxorubicin act synergistically on metastatic ovarian cancer

Cancer-killing virus and doxorubicin act synergistically on metastatic ovarian cancer

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A new approach to treatment using a cancer-killing virus combined with a chemotherapy drug may offer hope to those with advanced and recurrent forms of metastatic ovarian cancer.

Can consensus guidelines defining adequate margins decrease unnecessary breast cancer surgeries?

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Nearly one quarter of all women who underwent initial breast conservation surgery (BCS) for breast cancer had a subsequent surgical intervention.

FOLFIRI treatment response not related to colorectal cancer classification by gene expression

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The current classification system for colorectal cancer, based on genetic profiles, cannot be used to predict drug responses to FOLFIRI.

First targeted treatment to boost survival for esophageal cancer

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Patients with a specific type of esophageal cancer survived longer when they were given the latest lung cancer drug, according to trial results.

Exercise therapy benefits breast cancer survivors

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Exercise offers several benefits for breast cancer survivors, including reduced symptoms of lymphedema, according to a new study.

Improved survival in pediatric umbilical cord transplants for hematologic cancers

Improved survival in pediatric umbilical cord transplants for hematologic cancers

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A new standard of care for children facing acute myeloid leukemia (AML) may be clear, following a multiyear study.

Radiation exposure linked to aggressive thyroid cancers

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For the first time, researchers have found that exposure to radioactive iodine is associated with more aggressive forms of thyroid cancer, according to a careful study of over a thousand individuals.

Monitoring psychosocial function in radiotherapy

Monitoring psychosocial function in radiotherapy

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Psychosocial decline occurs in an estimated one-third of patients undergoing radiotherapy for cancer. These declines may sometimes be ameliorated by vigilant recognition of the need to refer patients for psychosocial support interventions.

Postoperative radiation therapy improves overall survival in resected NSCLC

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Patients with non-small lung cancer (NSCLC) that received postoperative radiation therapy (PORT) lived an average of 4 months longer, when compared with patients who had the same disease progression and treatment criteria.

Stereotactic body radiotherapy (SBRT) effective for inoperable early stage lung cancer

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Excellent long-term, local control for medically inoperable, early stage lung cancer patients is possible, according to a review of data from an institutional patient registry on stereotactic body radiotherapy (SBRT).

Combination treatment for metastatic melanoma results in longer overall survival

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Treatment with a combination of the drugs sargramostim plus ipilimumab, rather than ipilimumab alone, yielded longer overall survival and lower toxicity for patients with metastatic melanoma.

Cellular evidence for mind-body connection in breast cancer survivors

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Researchers have demonstrated that employing mindfulness meditation or being a member of a support group has a positive physical impact at the cellular level in breast cancer survivors.

Risk prediction improved by new classification in chronic lymphocytic leukemia

Risk prediction improved by new classification in chronic lymphocytic leukemia

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A new correlation discovered between specific molecular disease features and subgroups of patients with different prognoses could make identification of chronic lymphocytic leukemia (CLL) prognosis at the time of diagnosis possible.

Quality of biopsy directly linked to survival in patients with bladder cancer

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Researchers have demonstrated for the first time that the quality level of diagnostic staging using biopsy in patients with bladder cancer is directly linked with their survival.

Resection for lung cancer in the elderly: Lobectomy better than sublobar resection

Resection for lung cancer in the elderly: Lobectomy better than sublobar resection

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Significant advances have been made in screening for lung cancer and in targeting those patients who will benefit most from it. This study examines the impact of screening and treatment modalities on elderly patients.

Postsurgery readmission rates questioned as a quality measure in colorectal cancer care

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Hospital readmission rates after colorectal cancer surgery showed little variation when the data was adjusted to account for patient characteristics, coexisting illnesses, and operation types.

Breast cancer tumor response to neoadjuvant chemotherapy (NAC) measured

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Diffuse optical spectroscopic tomographic imaging (DOST) may be useful in predicting which patients will best respond to chemotherapy used to reduce breast cancer tumors before surgery, according to a new study.

Early palliative care can cut hospital readmissions for cancer patients

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A new, collaborative model in cancer care aims to reduce the rates at which patients go to intensive care or are readmitted to the hospital after discharge.

Trastuzumab shows benefit years after treatment for HER2+ breast cancer

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The addition of trastuzumab to chemotherapy significantly improved the overall and disease-free survival of women with early stage HER2-positive breast cancer.

Innovative program helps combat catheter-associated urinary tract infections (CAUTI)

Innovative program helps combat catheter-associated urinary tract infections (CAUTI)

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Oncology nurses at a New York cancer center successfully reduced the rate of CAUTIs at their facility to zero with a novel program that gives nurses autonomy in making care decisions for patients with urinary catheters.

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