Patient Outcomes

Improved tyrosine kinase inhibitor (TKI) selectively activates in tumor tissue, minimizing side effects in patients

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A new strategy developed by an interdisciplinary team of researchers aims to reduce the side effects connected to use of tyrosine kinase inhibitors (TKIs).

Immunotherapy added to radiotherapy may help overcome resistance to treatments

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Coupling immunotherapy to radiotherapy treatment could help prevent cancers from becoming resistant to treatment, according to a new study.

Current therapy for hypothyroidism endorsed by new guidelines

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A recent review has found insufficient consistent data exist to recommend a change in use of levothyroxine as the only drug needed to treat hypothyroidism.

Importance of sequence in chemotherapy administration

Importance of sequence in chemotherapy administration

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Is sequencing important when administering chemotherapy on the same day?

Nearly 5 percent of cancer patients die a month after surgery

Nearly 5 percent of cancer patients die a month after surgery

In a study of more than 1.1 million cancer patients who had surgery, almost 5 percent died within one month of their operation. Lack of access to quality care a major factor in these deaths, researchers say.

High-dose radiotherapy doesn't offer survival benefit in mesothelioma

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Treatnent with high-dose radiotherapy after chemotherapy and surgery for malignant pleural mesothelioma does not achieve improvements in local relapse and overall survival, according to phase II trial data.

Afatinib improves progression-free survival in head and neck cancer

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After failure of platinum-based chemotherapy, the tyrosine kinase inhibitor (TKI) afatinib significantly improved progression-free survival in patients with recurrent or metastatic squamous cell carcinoma of the head and neck.

Using guideline adherence to manage CINV effectively

Using guideline adherence to manage CINV effectively

Guidelines for managing chemotherapy-induced nausea and vomiting direct management toward risk assessment and prophylactic antiemetics.

HER2 inhibition shows promise in HER2-positive non-small cell lung cancer

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Human epidermal growth factor receptor 2 (HER2) mutations may offer an important treatment target in a subset of patients with non-small cell lung cancer.

Good news for young patients with a leukemia subtype with poor prognosis

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For younger patients with an acute lymphoblastic leukemia (ALL) subtype, modifying treatment based on chemotherapy response can make a vital difference.

Good bowel cleansing key for high-quality colonoscopy

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Successful colonoscopy is closely dependent on good bowel preparation, and poor bowel prep often leads to missed precancerous lesions.

E-cigarettes not helpful in smoking cessation among cancer patients

E-cigarettes not helpful in smoking cessation among cancer patients

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Smokers with cancer using e-cigarettes (in addition to traditional cigarettes) were found to be more nicotine dependent and equally or less likely to have quit smoking traditional cigarettes than nonusers.

Combination treatment for melanoma achieves significant progression-free survival and response rates

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Combination therapy with both BRAF inhibitor vemurafenib and MEK inhibitor cobimetinib achieved superior results over vemurafenib plus placebo for BRAF-mutation positive melanoma.

Adjuvant Lapatinib and/or Trastuzumab Treatment Optimization (ALTTO) study confirms use of trastuzumab for HER2-positive breast cancer

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The use of trastuzumab (Herceptin) as the standard-of-care treatment for HER2-positive breast cancer has been supported by the Adjuvant Lapatinib and/or Trastuzumab Treatment Optimization (ALTTO) study.

Tool successfully distinguishes between breast cancer and normal tissues

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Researchers have successfully tested a new tool that will help surgeons better distinguish cancerous breast tissue from normal tissue, which should lower the mount of repeat procedures needed.

Targeted combination therapy halts disease and extends life in advanced melanoma

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A targeted combination drug therapy has shown efficacy for metastatic melanoma, showing reduction in both mortality and disease progression.

New antifungal is as effective as existing drugs and with fewer adverse events

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A newly developed antifungal has proved as effective against invasive mold disease in cancer patients as the standardly used drug, voriconazole, with fewer side effects.

Ortho-oncology team achieves successful hip articulation by repurposing a shoulder surgical aid

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A shoulder surgical aid, known as the Spider Limb Positioner, was adapted successfully to conduct a left hip disarticulation on a patient with melanoma.

Once-weekly breast radiation regimen improves on current treatment

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An experimental regimen of once-weekly breast irradiation after lumpectomy provides more convenience to patients at less expense, and results in better completion rates of prescribed radiation treatment.

Prostate cancer treatment controversy continues as study finds watchful waiting not enough for some men

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An active controversy among oncologists concerns watchful waiting versus more active treatment for prostate cancer.

Concurrent radiation and chemotherapy after surgery effective in high-risk endometrial cancer

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Radiation therapy with concurrent paclitaxel chemotherapy after surgery can be effective to treat patients with high-risk endometrial cancer, according to new research.

Evidence-based design: A new concept in health care facilities that puts the focus on patients

Evidence-based design: A new concept in health care facilities that puts the focus on patients

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A medical center in New Jersey makes the most of a rare opportunity to rebuild from the ground up. Its innovative patient rooms follow evidence-based design, a new concept in health care architecture.

Olaparib tablet safe in patients with ovarian cancer who received pretreatment

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A PARP inhibitor in oral tablet form, given in combination with chemotherapy, was deemed safe for heavily pretreated patients with ovarian cancer.

Indeterminate melanoma cases reduced by three-quarters by diagnostic test

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Malignant melanoma was differentiated from benign skin lesions with high accuracy in a pivotal clinical utility study of the Myriad myPath Melanoma test.

Better classifications improve treatment planning for breast cancer

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Scientists have developed a tool to distinguish each breast cancer subtype, research that could improve treatments and targeting of treatments for the disease.

ASTRO: Prostate cancer recovery faster with less androgen deprivation therapy

ASTRO: Prostate cancer recovery faster with less androgen deprivation therapy

Shorter time to testosterone recovery with 18 versus 36 months androgen deprivation therapy.

Tumor cells prep lymphatic cells to encourage breast cancer cells to spread

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Breast cancer cells can lay the groundwork for their own metastasis throughout the body by coaxing cells within lymphatic vessels to send out tumor-welcoming signals.

Protein deletion predicts length of progression free survival (PFS) in patients with non-small cell lung cancer (NSCLC)

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Deletion of the Bcl-2-like protein 11 (BIM) in advanced non-small cell lung cancer has been associated with shorter progression free survival (PFS).

Risk of premature menopause after Hodgkin lymphoma treatment is mapped

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Women treated for Hodgkin lymphoma will be able to better understand their risks of future infertility after researchers estimated their risk of premature menopause with different treatments.

Patient and tumor characteristics in melanoma examined for clues to aggressive form of disease

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Researchers in Australia examined patient and tumor characteristics of melanomas for higher mitotic rates (a marker of tumor cell growth) in an effort to increase early detection.

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