Pancreatic Cancer

Favorable Perioperative Outcomes After Resection of Borderline Resectable Pancreatic Cancer Treated With Neoadjuvant Stereotactic Radiation and Chemotherapy Compared with Upfront Pancreatectomy for Resectable Cancer

Favorable Perioperative Outcomes After Resection of Borderline Resectable Pancreatic Cancer Treated With Neoadjuvant Stereotactic Radiation and Chemotherapy Compared with Upfront Pancreatectomy for Resectable Cancer

[Journal of Gastrointestinal Oncology] This research examines outcomes related to the use of neoadjuvant multi-agent chemotherapy and stereotactic body radiation therapy (SBRT) in borderline resectable pancreatic cancer (BRPC) or locally advanced pancreatic cancer (LAPC) patients.

How Does Obesity Influence Pancreatic Cancer Development and Treatment?

How Does Obesity Influence Pancreatic Cancer Development and Treatment?

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Research findings reveal the mechanism by which obesity increases inflammation and desmoplasia in the most frequent type of pancreatic cancer, using mouse models and human tissue samples.

Systematic Palliative Care Provides Greater Improvement in Quality of Life for Patients with Pancreatic Cancer

Systematic Palliative Care Provides Greater Improvement in Quality of Life for Patients with Pancreatic Cancer

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Quality of life is significantly improved for patients with pancreatic cancer when systematic palliative care is administered vs on-demand palliative care.

Metastatic Ability May Precede Tumor Formation in Pancreatic Cancer

Metastatic Ability May Precede Tumor Formation in Pancreatic Cancer

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Metastatic capabilities of pancreatic cancer might arise before tumors even form. Metastasis and advanced stage of disease at diagnosis are attributed to low survival rates for pancreatic cancer.

Novel Approach Uses Ultrasound to Enhance Efficacy of Chemotherapy in Pancreatic Cancer

Novel Approach Uses Ultrasound to Enhance Efficacy of Chemotherapy in Pancreatic Cancer

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Combining a laboratory ultrasound technique called sonoporation with the commercially available chemotherapy compound gemcitabine increases the porosity of pancreatic cells with microbubbles and helps get the drug into cancer cells.

Chemotherapy and Radiation Prior to Surgery Improves Outcomes in Patients With Pancreatic Cancer

Chemotherapy and Radiation Prior to Surgery Improves Outcomes in Patients With Pancreatic Cancer

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Despite the increased risk, patients whose pancreatic cancer tumor has grown to encompass critical blood vessels can be candidates for surgery. Data on efforts to fine-tune a protocol for these patients were presented at the SSAT 57th Annual Meeting.

Adjuvant Gemcitabine/Capecitabine: New Standard of Care for Resected Pancreatic Cancer

Adjuvant Gemcitabine/Capecitabine: New Standard of Care for Resected Pancreatic Cancer

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Adjuvant gemcitabine plus capecitabine significantly improved overall survival compared with gemcitabine monotherapy in patients with pancreatic ductal adenocarcinoma, according to results of the ESPAC-4 trial presented at the ASCO 2016 Annual Meeting.

Chemoradiotherapy Showed No Survival Benefit Over Chemotherapy in Locally Advanced Pancreatic Cancer

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Researchers discovered no survival benefit of chemoradiotherapy over chemotherapy in treating locally advanced pancreatic cancer in the LAP01 Randomized Clinical Trial.

Barriers to Understanding Pancreatic Cancer Can Be Overcome With Improvements to Online Health Information

Barriers to Understanding Pancreatic Cancer Can Be Overcome With Improvements to Online Health Information

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Available information on pancreatic cancer was written at too high a level and contained inaccuracies regarding alternative therapies, a recent study has shown.

Molecular profiling of a case of advanced pancreatic cancer identifies an active and tolerable combination of targeted therapy with backbone chemotherapy

Molecular profiling of a case of advanced pancreatic cancer identifies an active and tolerable combination of targeted therapy with backbone chemotherapy

[Journal of Gastrointestinal Oncology] This research reviews the case history of a patient with stage IVB pancreatic adenocarcinoma initially treated with gemcitabine and erlotinib who stopped therapy after 3 months without achieving a response and was switched to a different and effective combination strategy.

New Mechanism to Target RAS Genes Identified

New Mechanism to Target RAS Genes Identified

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A small molecule that inhibits RAS protein interactions offers hope for targeting this elusive protein. It is one of the most sought-after cancer targets for drug developers, but the mutant RAS protein lacks drug-binding pockets.

Readability of Online Pancreatic Cancer Info Varies

Readability of Online Pancreatic Cancer Info Varies

Lowest accuracy scores for alternative tx websites; websites with higher accuracy more difficult to read

Targeting Drugs to Pancreatic Cancer Through Implantable Device

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New research indicates a far greater efficacy in pancreatic cancer drug therapy delivered via implantable device than via IV.

Immune-stimulating Drug and Chemotherapy Show Early Promise for Pancreatic Cancer

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An experimental therapy looks to hold promise for tumor control treatment in pancreatic adenocarcinoma.

AACR: Oral Bacteria Tied to Pancreatic Cancer Risk

AACR: Oral Bacteria Tied to Pancreatic Cancer Risk

Two strains of oral bacteria -- P. gingivalis and A. actinomycetemcomitans -- have been linked to higher risk of pancreatic cancer.

Experimental Immune Therapy Tears Down Protective Microenvironment of Pancreatic Cancer Tumors

Experimental Immune Therapy Tears Down Protective Microenvironment of Pancreatic Cancer Tumors

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An experimental immune therapy can re-educate macrophages to tear down the scaffolding that surrounds and protects pancreatic cancer from chemotherapy.

Adjuvant Chemotherapy More Effective in Reducing Distant Pancreatic Cancer Metastasis

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Adding radiotherapy to chemotherapy and surgery reduced the number of local disease recurrences but did not affect distant recurrences or survival.

Researchers Believe Pancreatic Cancer Is Four Separate Diseases

Researchers Believe Pancreatic Cancer Is Four Separate Diseases

Researchers identified four classes of genetic error that triggered pancreatic tumors and classified pancreatic cancer as four separate diseases.

Neem Tree Extract Demonstrates Anticancer Activity Against Pancreatic Cancer

Neem Tree Extract Demonstrates Anticancer Activity Against Pancreatic Cancer

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A natural extract from the neem tree of India is found to have potential as a treatment for pancreatic cancer.

Implantable Device Delivers Anticancer Regimen Directly Into Pancreatic Cancer Tumors

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An implantable device allows large doses of highly toxic drugs to be delivered directly to pancreatic tumors while reducing exposure to the toxic side effects in the rest of the body.

Nanoparticle Drug Delivery Aims to Control Pancreatic Tumor and Inhibit Escape Pathways

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Use of a nanoparticle to deliver drugs may reduce tumors and suppress metastatic escape. These efforts offer a way to control drug release over space and time while reducing systemic drug exposure and the associated side effects.

CDK4/6 Inhibitors Exploit a Unique Vulnerability in Pancreatic Cancer

CDK4/6 Inhibitors Exploit a Unique Vulnerability in Pancreatic Cancer

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The metabolism of pancreatic cancer cells is altered by the anticancer activity of CDK4/6 inhibitors. Researchers hope this biologic vulnerability could be exploited to treat pancreatic cancer.

Adding Leucovorin to S-1 Improves PFS in Advanced Pancreatic Cancer

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The addition of leucovorin to S-1 significantly improved progression-free survival compared with S-1 alone in patients with advanced pancreatic cancer who were refractory to gemcitabine.

Family Members of Patients With CUP Are At Increased Risk for Several Types of Cancer

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Family members of patients with cancers of unknown primary (CUP) are at higher risk of developing CUP themselves, as well as cancers of the lung, pancreas, and colon and some cancers of the blood.

Portal Vein Blood Leads to Earlier, More Accurate Pancreatic Cancer Diagnosis

Portal Vein Blood Leads to Earlier, More Accurate Pancreatic Cancer Diagnosis

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Blood samples collected from the portal vein can tell physicians far more about a patient's pancreatic cancer than peripheral blood collected from a more easily accessed vein in the arm.

Investigational Drug Is Effective Against Debilitating Adverse Effect of Cancer in Preclinical Trials

Investigational Drug Is Effective Against Debilitating Adverse Effect of Cancer in Preclinical Trials

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New data describes how an experimental drug can stop the debilitating and life-threatening adverse effect cachexia commonly associated with advanced cancers and restore muscle health.

Blood Sample Offers a New Way of Detecting Cancer

Blood Sample Offers a New Way of Detecting Cancer

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RNA test of blood platelets can detect, classify, and pinpoint the location of cancer by analyzing a sample equivalent to 1 drop of blood. Using this new method, researchers were able to identify cancer with 96% accuracy.

Nanoliposomal Irinotecan Extends Survival in Metastatic Pancreatic Cancer

Nanoliposomal Irinotecan Extends Survival in Metastatic Pancreatic Cancer

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Nanoliposomal irinotecan in combination with fluorouracil and folinic acid improves survival in patients with pancreatic ductal adenocarcinoma.

Study Findings Explain Why Chemotherapy May be Compromised in Patients With Pancreatic Cancer

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Study findings may explain why chemotherapy drugs such as gemcitabine are not effective for many patients with pancreatic cancer, and perhaps point to new approaches to treatment including enhancing gemcitabine's ability to stop tumor growth.

Blood Test Can Guide Treatment Sequencing for Pancreatic Cancer

Blood Test Can Guide Treatment Sequencing for Pancreatic Cancer

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A widely available, inexpensive blood test can predict outcomes and guide treatment in pancreatic cancer; however, only 1 in 5 US patients with the disease have the blood test.

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