Pancreatic Cancer

Utilization and Trends in Palliative Therapy for Stage IV Pancreatic Adenocarcinoma Patients: A U.S. Population-based Study

Utilization and Trends in Palliative Therapy for Stage IV Pancreatic Adenocarcinoma Patients: A U.S. Population-based Study

[Journal of Gastrointestinal Oncology] This research examined patients who presented with metastatic pancreatic adenocarcinoma at diagnosis, and their patterns of palliative care utilization.

CAR, PNI Levels Correlate with Outcomes in Pancreatic Cancer

CAR, PNI Levels Correlate with Outcomes in Pancreatic Cancer

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An association was found between low PNI/high CAR levels and poor outcomes in operable pancreatic ductal adenocarcinoma, even in patients who undergo curative resection.

Navigating Colorectal and Pancreatic Cancer Patients in a Multidisciplinary Cancer Center

Navigating Colorectal and Pancreatic Cancer Patients in a Multidisciplinary Cancer Center

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By identifying incidence, prevalence, and risk factors for colorectal and pancreatic cancer in our communities, nurse navigators can develop screening and prevention programs to better serve these populations.

Genome-Informed Treatment Improves Survival in Pancreatic Cancer

Genome-Informed Treatment Improves Survival in Pancreatic Cancer

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Precision Medicine Improves Pancreatic Cancer Treatment

Cisplatin Plus Standard-of-Care Regimen Reduced Tumors in Advanced Pancreatic Cancer

Cisplatin Plus Standard-of-Care Regimen Reduced Tumors in Advanced Pancreatic Cancer

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Cisplatin plus standard-of-care gemcitabine/nab-paclitaxel improved tumor shrinkage in patients with metastatic pancreatic cancer, according to a study by the HonorHealth Research Institute and the Translational Genomics Research Institute.

Biopolymer Delivery of Synergistic Immunotherapy Could Improve Efficacy

Biopolymer Delivery of Synergistic Immunotherapy Could Improve Efficacy

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Biopolymer codelivery of CAR T cells and stimulator of IFN genes directly to the surface of solid tumors more effectively reduced tumor size.

Onset or Rapid Worsening of Diabetes May Indicate Pancreatic Cancer

Onset or Rapid Worsening of Diabetes May Indicate Pancreatic Cancer

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An investigation into whether onset or worsening of diabetes causes pancreatic cancer or vice versa was presented at the 2017 European Cancer Congress.

Postoperative Gemcitabine Plus Capecitabine: A New Standard of Care for Pancreatic Cancer

Postoperative Gemcitabine Plus Capecitabine: A New Standard of Care for Pancreatic Cancer

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Use of Adjuvant gemcitabine plus capecitabine for patients with pancreatic cancer who have undergone tumor resection resulted in a modest increase short-term survival.

Study Raises Questions About PDX1 as a Potential Pancreatic Cancer Target

Study Raises Questions About PDX1 as a Potential Pancreatic Cancer Target

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PDX1 appears to have distinct roles at different stages of pancreatic cancer development.

Selumetinib + MK-2206 Fails to Improve Survival vs mFOLFOX in Pancreatic Cancer

Selumetinib + MK-2206 Fails to Improve Survival vs mFOLFOX in Pancreatic Cancer

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Seluminitinib in combination with an AKT inhibitor did not improve survival compared with modified FOLFOX in previously treated metastatic pancreatic cancer.

Favorable Perioperative Outcomes After Resection of Borderline Resectable Pancreatic Cancer Treated With Neoadjuvant Stereotactic Radiation and Chemotherapy Compared with Upfront Pancreatectomy for Resectable Cancer

Favorable Perioperative Outcomes After Resection of Borderline Resectable Pancreatic Cancer Treated With Neoadjuvant Stereotactic Radiation and Chemotherapy Compared with Upfront Pancreatectomy for Resectable Cancer

[Journal of Gastrointestinal Oncology] This research examines outcomes related to the use of neoadjuvant multi-agent chemotherapy and stereotactic body radiation therapy (SBRT) in borderline resectable pancreatic cancer (BRPC) or locally advanced pancreatic cancer (LAPC) patients.

How Does Obesity Influence Pancreatic Cancer Development and Treatment?

How Does Obesity Influence Pancreatic Cancer Development and Treatment?

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Research findings reveal the mechanism by which obesity increases inflammation and desmoplasia in the most frequent type of pancreatic cancer, using mouse models and human tissue samples.

Systematic Palliative Care Provides Greater Improvement in Quality of Life for Patients with Pancreatic Cancer

Systematic Palliative Care Provides Greater Improvement in Quality of Life for Patients with Pancreatic Cancer

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Quality of life is significantly improved for patients with pancreatic cancer when systematic palliative care is administered vs on-demand palliative care.

Metastatic Ability May Precede Tumor Formation in Pancreatic Cancer

Metastatic Ability May Precede Tumor Formation in Pancreatic Cancer

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Metastatic capabilities of pancreatic cancer might arise before tumors even form. Metastasis and advanced stage of disease at diagnosis are attributed to low survival rates for pancreatic cancer.

Novel Approach Uses Ultrasound to Enhance Efficacy of Chemotherapy in Pancreatic Cancer

Novel Approach Uses Ultrasound to Enhance Efficacy of Chemotherapy in Pancreatic Cancer

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Combining a laboratory ultrasound technique called sonoporation with the commercially available chemotherapy compound gemcitabine increases the porosity of pancreatic cells with microbubbles and helps get the drug into cancer cells.

Chemotherapy and Radiation Prior to Surgery Improves Outcomes in Patients With Pancreatic Cancer

Chemotherapy and Radiation Prior to Surgery Improves Outcomes in Patients With Pancreatic Cancer

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Despite the increased risk, patients whose pancreatic cancer tumor has grown to encompass critical blood vessels can be candidates for surgery. Data on efforts to fine-tune a protocol for these patients were presented at the SSAT 57th Annual Meeting.

Adjuvant Gemcitabine/Capecitabine: New Standard of Care for Resected Pancreatic Cancer

Adjuvant Gemcitabine/Capecitabine: New Standard of Care for Resected Pancreatic Cancer

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Adjuvant gemcitabine plus capecitabine significantly improved overall survival compared with gemcitabine monotherapy in patients with pancreatic ductal adenocarcinoma, according to results of the ESPAC-4 trial presented at the ASCO 2016 Annual Meeting.

Chemoradiotherapy Showed No Survival Benefit Over Chemotherapy in Locally Advanced Pancreatic Cancer

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Researchers discovered no survival benefit of chemoradiotherapy over chemotherapy in treating locally advanced pancreatic cancer in the LAP01 Randomized Clinical Trial.

Barriers to Understanding Pancreatic Cancer Can Be Overcome With Improvements to Online Health Information

Barriers to Understanding Pancreatic Cancer Can Be Overcome With Improvements to Online Health Information

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Available information on pancreatic cancer was written at too high a level and contained inaccuracies regarding alternative therapies, a recent study has shown.

Molecular profiling of a case of advanced pancreatic cancer identifies an active and tolerable combination of targeted therapy with backbone chemotherapy

Molecular profiling of a case of advanced pancreatic cancer identifies an active and tolerable combination of targeted therapy with backbone chemotherapy

[Journal of Gastrointestinal Oncology] This research reviews the case history of a patient with stage IVB pancreatic adenocarcinoma initially treated with gemcitabine and erlotinib who stopped therapy after 3 months without achieving a response and was switched to a different and effective combination strategy.

New Mechanism to Target RAS Genes Identified

New Mechanism to Target RAS Genes Identified

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A small molecule that inhibits RAS protein interactions offers hope for targeting this elusive protein. It is one of the most sought-after cancer targets for drug developers, but the mutant RAS protein lacks drug-binding pockets.

Readability of Online Pancreatic Cancer Info Varies

Readability of Online Pancreatic Cancer Info Varies

Lowest accuracy scores for alternative tx websites; websites with higher accuracy more difficult to read

Targeting Drugs to Pancreatic Cancer Through Implantable Device

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New research indicates a far greater efficacy in pancreatic cancer drug therapy delivered via implantable device than via IV.

Immune-stimulating Drug and Chemotherapy Show Early Promise for Pancreatic Cancer

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An experimental therapy looks to hold promise for tumor control treatment in pancreatic adenocarcinoma.

AACR: Oral Bacteria Tied to Pancreatic Cancer Risk

AACR: Oral Bacteria Tied to Pancreatic Cancer Risk

Two strains of oral bacteria -- P. gingivalis and A. actinomycetemcomitans -- have been linked to higher risk of pancreatic cancer.

Experimental Immune Therapy Tears Down Protective Microenvironment of Pancreatic Cancer Tumors

Experimental Immune Therapy Tears Down Protective Microenvironment of Pancreatic Cancer Tumors

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An experimental immune therapy can re-educate macrophages to tear down the scaffolding that surrounds and protects pancreatic cancer from chemotherapy.

Adjuvant Chemotherapy More Effective in Reducing Distant Pancreatic Cancer Metastasis

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Adding radiotherapy to chemotherapy and surgery reduced the number of local disease recurrences but did not affect distant recurrences or survival.

Researchers Believe Pancreatic Cancer Is Four Separate Diseases

Researchers Believe Pancreatic Cancer Is Four Separate Diseases

Researchers identified four classes of genetic error that triggered pancreatic tumors and classified pancreatic cancer as four separate diseases.

Neem Tree Extract Demonstrates Anticancer Activity Against Pancreatic Cancer

Neem Tree Extract Demonstrates Anticancer Activity Against Pancreatic Cancer

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A natural extract from the neem tree of India is found to have potential as a treatment for pancreatic cancer.

Implantable Device Delivers Anticancer Regimen Directly Into Pancreatic Cancer Tumors

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An implantable device allows large doses of highly toxic drugs to be delivered directly to pancreatic tumors while reducing exposure to the toxic side effects in the rest of the body.

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