For pancreatic cancer, chokeberry extract may enhance effectiveness of gemcitabine
the ONA take:
According to a new study published in the Journal of Clinical Pathology, chokeberry, a wild berry, may improve the effectiveness of gemcitabine for the treatment of pancreatic cancer. In the study, researchers tested gemcitabine alone, different levels of chokeberry (Aronia melanocarpa) extract alone, and a combination of both on AsPC-1 pancreatic cancer cells in vitro. Researchers found that 1 ug/mL of chokeberry extract induced some cancer cell death after 48 hours.
Furthermore, when low doses of chokeberry extract were administered with low doses of gemcitabine, the extract greatly strengthened the effectiveness of gemcitabine. Chokeberry extract had no effect on other normal lining cells, even at doses as high as 50 ug/mL.
Chokeberry is a wild berry that grows along the eastern portion of North America, particularly in wetlands and swamps. Previous research has shown that chokeberries have high concentrations of vitamins and antioxidants, such as numerous polyphenols. Other studies have demonstrated that chokeberry has induced apoptosis in brain cancer.
The researchers suggest that adding "nutraceuticals" like chokeberry to traditional chemotherapy may enhance the effectiveness, especially in difficult to treat cancers like pancreatic cancer.
Chokeberry may improve the effectiveness of gemcitabine for the treatment of pancreatic cancer.
A wild berry native to North America may strengthen the effectiveness of a chemotherapy drug commonly used to treat pancreatic cancer, reveals experimental research published online in the Journal of Clinical Pathology. The findings prompt the researchers to suggest that adding 'nutraceuticals' to chemotherapy cycles may improve the effectiveness of conventional drugs, particularly in hard to treat cancers, such as pancreatic cancer.
They base their findings on the effectiveness of extract of chokeberry (Aronia melanocarpa) in killing off cancer cells - a process known as apoptosis. Chokeberry is a wild berry that grows on the eastern side of North America in wetlands and swamp areas. The berry is high in vitamins and antioxidants, including various polyphenols - compounds that are believed to mop up the harmful by-products of normal cell activity.
Sign Up for Free e-newsletters
- Avoiding the ED: Planned Strategies for Unplanned Urgent Cancer Care
- NP-Led Clinics Improved Phase 1 Oncology Study Operations, Outcomes
- Art as Palliative Care: Bedside Intervention Improves Pain, Anxiety, Mood in Hospitalized Cancer Patients
- Unprotected Sex After Chemotherapy
- Mindfulness Training May Improve End-of-Life Conversations in Advanced Cancer
- Aligning Patient Goals With End of Life Treatment Decisions
- Study Suggests Greater Focus on the Needs of Family Caregivers of Patients With Cancer
- First Antibody-Based Treatment Regimen Approved for First-Line Treatment of Multiple Myeloma
- Increased Diabetes Risk Associated With Cancer Development
- Childhood Neuroblastoma Survivors at Risk for Psych Impairment
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
|Head and Neck Cancer||Regimens||Drugs|