Paclitaxel

Research Identifies Underlying Mechanism of Chemotherapy-Induced Peripheral Neuropathy

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A previously unidentified avenue exists for potential therapies for peripheral neuropathy induced by the chemotherapeutic agent paclitaxel.

Weekly Paclitaxel Doesn't Increase Survival in Ovarian Cancer

Weekly Paclitaxel Doesn't Increase Survival in Ovarian Cancer

Paclitaxel administered with carboplatin on a weekly basis is not associated with improved progression-free survival.

Concurrent Chemoradiotherapy Using Paclitaxel Plus Cisplatin in the Treatment of Elderly Patients With Esophageal Cancer

Concurrent Chemoradiotherapy Using Paclitaxel Plus Cisplatin in the Treatment of Elderly Patients With Esophageal Cancer

The purpose of this research was to examine both efficiency and safety of concurrent chemoradiotherapy (CCRT) using paclitaxel combined with cisplatin in elderly esophageal cancer patients.

Artificial Intelligence May Better Predict Response in Breast Cancer Treatment

Artificial Intelligence May Better Predict Response in Breast Cancer Treatment

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Researchers are working on a way to use artificial intelligence to predict a patient's response to two common chemotherapy drugs used to treat breast cancer: paclitaxel and gemcitabine.

Molecular tinkering doubles cancer drug's efficacy

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By surrounding molecules of paclitaxel with self-assembling spheres composed of amino acids, researchers doubled tumor exposure to the drug and reduced its effects on healthy tissue.

Fostamatinib-paclitaxel combination may shrink ovarian cancers

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Researchers have found that the experimental drug fostamatinib, combined with the chemotherapy drug paclitaxel, may overcome ovarian cancer cells' resistance to paclitaxel.

Rare gene variants associated with side effects from paclitaxel

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Researchers have identified the first genetic marker associated with severe neurologic toxicity from paclitaxel.

Importance of sequence in administering premeds with paclitaxel

Importance of sequence in administering premeds with paclitaxel

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In what sequence should you administer premedications prior to paclitaxel: Should the antihistamine be given first or the steroid?

Nab-paclitaxel demonstrated superior activity vs paclitaxel in early breast cancer

Nab-paclitaxel demonstrated superior activity vs paclitaxel in early breast cancer

Nab-paclitaxel has demonstrated significant benefit for patients with early high-risk breast cancer when compared with conventional solvent-based paclitaxel, according to recent research.

Reconstituting nab-paclitaxel

Reconstituting nab-paclitaxel

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Is there a good reason to mix nab-paclitaxel (Abraxane) with warm (not cool) normal saline when reconstituting?

Concurrent radiation and chemotherapy after surgery effective in high-risk endometrial cancer

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Radiation therapy with concurrent paclitaxel chemotherapy after surgery can be effective to treat patients with high-risk endometrial cancer, according to new research.

Nab-paclitaxel plus gemcitabine up pancreatic cancer survival

Nab-paclitaxel plus gemcitabine up pancreatic cancer survival

For patients with metastatic pancreatic cancer, treatment with albumin-bound paclitaxel (nab-paclitaxel) plus gemcitabine is more effective than gemcitabine alone.

Common food additive may prevent peripheral neuropathy from chemotherapy

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Working with cells in test tubes and in mice, researchers discovered that a chemical commonly used as a dog food preservative prevents chemotherapy-associated peripheral neuropathy.

ASCO: Weekly paclitaxel effective as standard-dose regimen in breast CA

ASCO: Weekly paclitaxel effective as standard-dose regimen in breast CA

For women with breast cancer, low-dose weekly paclitaxel is as effective as the standard-dose regimen given every two weeks, with fewer side effects.

FDA Update November/December 2012

Paclitaxel protein-bound particles for injectable suspension, 90-minute infusion of rituximab, omacetaxine mepesuccinate receive FDA approval

New drug combination improved overall survival in advanced pancreatic cancer

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Overall survival was significantly improved in patients with late-stage pancreatic cancer who received a new combination of cancer drugs compared with those who received standard treatment.

Infusing paclitaxel without an inline filter

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What are the potential problems associated with infusing paclitaxel without an inline filter?

A new era in management of
 gastrointestinal cancers

A new era in management of
 gastrointestinal cancers

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Key studies presented at the 2011 Oncology Congress focus on treatments, prevention, and early diagnosis of GI tract cancers.

Update affirms breast cancer treatment guidelines

The Clinical Practice Guide­lines in Oncology for Breast Cancer, published by NCCN, have been updated to affirm the existing recommendation regarding the use of bevacizumab (Avastin) for the treatment of metastatic breast cancer.

Adjuvant therapy in breast cancer

Weekly paclitaxel adjuvant therapy for breast cancer may result in better overall survival than other regimens, the results of a US study suggest.

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