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OXSORALEN
Pigmentation disorders
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Drug Name:

OXSORALEN Rx

Generic Name and Formulations:
Methoxsalen 1%; lotion; contains alcohol 71%.

Company:
Valeant Pharmaceuticals, Inc

Therapeutic Use:

Indications for OXSORALEN:

As a topical repigmenting agent in vitiligo in conjunction with controlled doses of ultraviolet A (320–400 nm) or sunlight.

Adult:

Individualize. Use gloves or finger cots to apply. Apply to to well-defined area of vitiligo, then expose to suitable source of UVA. Treatment intervals should be regulated by erythema response; generally once a week is recommended or less often depending on results. Pigmentation may begin after a few weeks with significant repigmentation after 6 to 9 months of treatment. Repigmentation occurs more rapidly in fleshy areas (eg, face, abdomen, buttocks) and less rapidly in less fleshy areas (eg, dorsum of the hands or feet).

Children:

Not recommended.

Contraindications:

Idiosyncratic reactions to psoralen compounds. Melanoma or history of. Invasive skin carcinoma. Photosensitivity diseases (eg, porphyria, acute lupus erythematosus, xeroderma pigmentosum). Children <12yrs.

Warnings/Precautions:

To be used only by physicians; do not dispense to patients. Keep treated areas protected from sun. Possible increased risk of skin cancer; caution in patients with fair-skin, or those with history of prior coal tar UV treatment, or who have had ionizing radiation, or taken arsenical compounds. Pregnancy (Cat.C). Nursing mothers.

Interactions:

Caution with concomitant photosensitizing agents (eg, anthralin, coal tar or derivatives, griseofulvin, phenothiazines, nalidixic acid, halogenated salicylanilides, sulfonamides, tetracyclines, thiazides, certain organic staining dyes).

Pharmacological Class:

Psoralen.

Adverse Reactions:

Severe burns (from overexposure to UVA).

How Supplied:

Lotion—1oz

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