Neoadjuvant Chemotherapy Use on the Rise in Ovarian Cancer Treatment

This article originally appeared here.
Neoadjuvant Chemotherapy Use Up in Ovarian Cancer Treatment
Neoadjuvant Chemotherapy Use Up in Ovarian Cancer Treatment

(HealthDay News) -- For patients with stage IIIC to IV ovarian cancer, neoadjuvant chemotherapy (NACT) use increased from 2003 to 2012, according to a study published online Sept. 6 in the Journal of Clinical Oncology.

Larissa A. Meyer, M.D., from the University of Texas MD Anderson Cancer Center in Houston, and colleagues examined the use of NACT versus primary cytoreductive surgery (PCS) in a multi-center observational study. Data were included for 1,538 women with stages IIIC to IV ovarian cancer who were diagnosed between 2003 and 2012. Overall survival, morbidity, and postoperative residual disease were compared in a propensity-score matched sample of 594 patients.

Continue Reading Below

The researchers found that from 2003-2010 to 2011-2012 there was an increase in NACT use from 16 to 34 percent in stage IIIC disease and from 41 to 62 percent in stage IV disease (both Ptrend < 0.001). There was variation by institution in adoption of NACT, from 8 to 30 percent for stage IIIC disease (P < 0.001) and from 27 to 61 percent for stage IV disease (P = 0.007). NACT correlated with shorter overall survival in stage IIIC disease compared with PCS (hazard ratio, 1.40; 95 percent confidence interval, 1.11 to 1.77), but not in stage IV disease (hazard ratio, 1.16; 95 percent confidence interval, 0.89 to 1.52).

"Future studies should prospectively consider the efficacy of NACT by extent of residual disease in unselected patients," the authors write.

Several authors disclosed financial ties to the biopharmaceutical industry.

Abstract
Full Text (subscription or payment may be required)

Loading links....
You must be a registered member of ONA to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs