ADD THIS DRUG TO MY LIST

Select the drug indication to add to your list

OTEZLA
Arthritis/rheumatic disorders
Psoriasis
Compare To Related Drugs
View/Edit/Compare Drugs In My List

Only 4 drugs may be compared at once

Drug Name:

OTEZLA Rx

Generic Name and Formulations:
Apremilast 10mg, 20mg, 30mg; tabs.

Company:
Celgene Corp

Therapeutic Use:

Indications for OTEZLA:

Active psoriatic arthritis.

Adult:

Swallow whole. Initially titrate over 5 days. Starting on Day 1: 10mg in the AM. Day 2: 10mg in AM and 10mg in PM. Day 3: 10mg in AM and 20mg in PM. Day 4: 20mg in AM and 20mg in PM. Day 5: 20mg in AM and 30mg in PM. Following on Day 6 and thereafter: 30mg twice daily (AM & PM). Severe renal impairment (CrCl <30mL/min): reduce to 30mg once daily; for initial titration, use only AM dose schedule and skip PM doses.

Children:

<18yrs: not established.

Warnings/Precautions:

Risk of severe diarrhea, nausea, and vomiting; monitor patients susceptible to complications (eg, elderly, volume depleted, hypotension); consider reducing dose or suspending therapy if occurs. History of depression and/or suicidal thoughts or behaviors; monitor for clinical worsening or other mood changes. Monitor weight regularly; evaluate and consider discontinuing if unexplained or significant weight loss occurs. Renal impairment. Pregnancy (Cat.C). Nursing mothers.

Interactions:

Concomitant strong CYP450 inducers (eg, rifampin, phenobarbital, carbamazepine, phenytoin): not recommended.

Pharmacological Class:

Phosphodiesterase 4 (PDE4) inhibitor.

Adverse Reactions:

Diarrhea, nausea, headache, upper respiratory tract infection, vomiting, nasopharyngitis, upper abdominal pain; weight loss, depression.

Note:

Register pregnant patients exposed to Otezla by calling (877) 311-8972.

How Supplied:

Tabs 30mg—60; 2-week starter pack—13+14; 28-day starter pack—13+42; Carton—2x14

Indications for OTEZLA:

Moderate-to-severe plaque psoriasis, in adults who are candidates for phototherapy or systemic therapy.

Adult:

Swallow whole. Initially titrate over 5 days. Starting on Day 1: 10mg in the AM. Day 2: 10mg in AM and 10mg in PM. Day 3: 10mg in AM and 20mg in PM. Day 4: 20mg in AM and 20mg in PM. Day 5: 20mg in AM and 30mg in PM. Following on Day 6 and thereafter: 30mg twice daily (AM & PM). Severe renal impairment (CrCl <30mL/min): reduce to 30mg once daily; for initial titration, use only AM dose schedule and skip PM doses.

Children:

<18yrs: not established.

Warnings/Precautions:

Risk of severe diarrhea, nausea, and vomiting; monitor patients susceptible to complications (eg, elderly, volume depleted, hypotension); consider reducing dose or suspending therapy if occurs. History of depression and/or suicidal thoughts or behaviors; monitor for clinical worsening or other mood changes. Monitor weight regularly; evaluate and consider discontinuing if unexplained or significant weight loss occurs. Renal impairment. Pregnancy (Cat.C). Nursing mothers.

Interactions:

Concomitant strong CYP450 inducers (eg, rifampin, phenobarbital, carbamazepine, phenytoin): not recommended.

Pharmacological Class:

Phosphodiesterase 4 (PDE4) inhibitor.

Adverse Reactions:

Diarrhea, nausea, headache, upper respiratory tract infection, vomiting, nasopharyngitis, upper abdominal pain; weight loss, depression.

Note:

Note: Register pregnant patients exposed to Otezla by calling (877) 311-8972.

How Supplied:

Tabs 30mg—60; 2-week starter pack—13+14; 28-day starter pack—13+42; Carton—2x14

Sign Up for Free e-newsletters

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs