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Orphenadrine 25mg/Aspirin 385mg/Caffeine 30mg
Musculoskeletal pain
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Drug Name:

Orphenadrine 25mg/Aspirin 385mg/Caffeine 30mg Rx

Generic Name and Formulations:
Orphenadrine citrate 25mg, aspirin 385mg, caffeine 30mg; tabs.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Orphenadrine 25mg/Aspirin 385mg/Caffeine 30mg:

Painful musculoskeletal conditions.

Adult:

1–2 tabs 3–4 times daily.

Children:

Not recommended.

Contraindications:

NSAID allergy. Varicella or influenza in teenagers. Glaucoma. Achalasia. GU or GI obstruction. Myasthenia gravis.

Warnings/Precautions:

Coronary disease, insufficiency or tachycardia. History of bronchospasm. Peptic ulcer. Coagulation disorders. Monitor blood pressure, BUN, uric acid levels. Pregnancy (Cat.C). Nursing mothers.

Interactions:

Increased risk of GI bleed/ulcer with alcohol, aspirin, NSAIDs, corticosteroids, anticoagulants. Potentiates oral hypoglycemics, anticholinergics, protein-bound drugs (eg, warfarin). Antagonizes steroids, barbiturates, phenylbutazone, uricosurics. Tremor and mental confusion with propoxyphene.

See Also:

Orphenadrine 50mg/Aspirin 770mg/Caffeine 60mg

Pharmacological Class:

Anticholinergic + salicylate.

Adverse Reactions:

Tachycardia, transient dizziness or syncope, GI upset/bleed, anticholinergic effects (eg, dry mouth, blurred vision, increased intraocular pressure, urinary retention), weakness, headache, rash, blood dyscrasias.

Note:

Formerly known under the brand names Norgesic (25/385/30); Norgesic Forte (50/770/60).

How Supplied:

Contact supplier.

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