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ONCASPAR
Leukemias, lymphomas, and other hematologic cancers
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Drug Name:

ONCASPAR Rx

Generic Name and Formulations:
Pegaspargase 750 IU/mL; soln for IV or IM inj; preservative-free.

Company:
Baxalta

Therapeutic Use:

Indications for ONCASPAR:

First-line acute lymphoblastic leukemia (including patients with asparaginase hypersensitivity).

Adults and Children:

Give by IV inj over 1–2hrs or by IM inj (max 2mL/inj site). 2500 IU/m2 no more frequently than every 14 days.

Contraindications:

History of pancreatitis, serious hemorrhage, or thrombosis with prior L-asparaginase therapy.

Warnings/Precautions:

Have resuscitation equipment available and observe patient for 1hr post-dose. Monitor serum glucose, coagulation parameters. Discontinue if serious allergic reactions, thrombotic events, or pancreatitis occur. Monitor for hepatotoxicity and abnormal liver function. Pregnancy (Cat.C). Nursing mothers: not recommended.

Pharmacological Class:

Enzyme.

Adverse Reactions:

Allergic reactions (including anaphylaxis), hyperglycemia, pancreatitis, CNS thrombosis, coagulopathy, hyperbilirubinemia, elevated transaminases, hyperlipidemia.

How Supplied:

Single-use vial (5mL)—1

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