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OCTAPLAS
Bleeding disorders
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Drug Name:

OCTAPLAS Rx

Generic Name and Formulations:
Pooled plasma (human) 45–70mg/mL; soln for IV infusion; solvent/detergent treated; frozen; pyrogen-free.

Company:
Octapharma

Therapeutic Use:

Indications for OCTAPLAS:

Replacement of multiple coagulation factors with acquired deficiencies due to liver disease, undergoing cardiac surgery, or liver transplant. Plasma exchange in thrombotic thrombocytopenic purpura (TTP).

Adult:

For IV infusion only after thawing. Administer based on ABO-blood group compatibility. Coagulation factors replacement: initially 10–15mL/kg to increase plasma coagulation factor levels approx. 15–25%; if hemostasis is not achieved, use higher doses. Adjust based on response; monitor aPTT, PT, and/or specific coagulation factors. TTP: usually 1–1.5 plasma volumes (40–60mL/kg) to completely replace plasma volume removed during plasmapheresis.

Children:

Not established.

Contraindications:

IgA deficiency. Severe Protein S deficiency. Prior hypersensitivity to fresh frozen plasma or plasma-derived products including plasma protein.

Warnings/Precautions:

Risk of transfusion reactions with ABO blood group mismatches. Risk of hypervolemia with high infusion rates; monitor for signs/symptoms of pulmonary edema or cardiac failure. Hyperfibrinolysis may develop due to low levels of alpha2-antiplasmin; monitor for signs of excessive bleeding in liver transplantation. Monitor for thrombosis. Risk of citrate toxicity; use max infusion rate: 0.020–0.025mmol citrate/kg/min (eg, Octaplas <1mL/kg/min). Contains human plasma; monitor for possible infection transmission (eg, viruses, Creutzfeldt-Jakob disease agent). Elderly. Labor & delivery. Pregnancy (Cat.C). Nursing mothers.

Interactions:

Avoid injecting calcium-containing drugs in same IV line.

Pharmacological Class:

Pooled plasma (human).

Adverse Reactions:

Pruritus, urticaria, nausea, headache, paresthesia; anaphylactic shock, citrate toxicity, severe hypotension.

How Supplied:

Soln—200mL

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