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NuLYTELY
Constipation and bowel cleansers
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Drug Name:

NuLYTELY Rx

Generic Name and Formulations:
Polyethylene glycol 3350 420g, sodium bicarbonate 5.72g, sodium chloride 11.2g, potassium chloride 1.4g; per 4L of soln; pwd for reconstitution; cherry, lemon-lime, orange, or pineapple flavor.

Company:
Braintree Laboratories, Inc.

Therapeutic Use:

Indications for NuLYTELY:

Bowel cleansing before colonoscopy.

Adult:

May consume water or clear liquids during and after completion of bowel prep up until 2hrs before procedure. Drink 240mL orally every 10 mins or 20–30mL/min by NG tube until rectal effluent is clear or 4L consumed. May interrupt if severe GI disturbances occur.

Children:

<6 months: not recommended. ≥6 months: May consume water or clear liquids during and after completion of bowel prep up until 2hrs before procedure. Drink 25mL/kg per hour orally or by NG tube until rectal effluent is clear or 4L consumed. May interrupt if severe GI disturbances occur.

Contraindications:

GI obstruction. Bowel perforation. Gastric retention. Ileus. Toxic colitis or megacolon.

Warnings/Precautions:

Not for direct ingestion. Correct fluid/electrolyte abnormalities before use. History of prolonged QT, uncontrolled arrhythmias, recent MI, unstable angina, CHF, or cardiomyopathy: increased risk of arrhythmias; consider ECGs at pre-dose and post-colonoscopy. History or risk of seizures. Renal impairment; monitor baseline and post-colonoscopy electrolytes, creatinine, BUN. Inflammatory bowel disease. Rule out suspected GI obstruction/perforation before administering. Severe ulcerative colitis. Impaired gag reflex. Semi- or unconscious patients. Risk of regurgitation or aspiration. Monitor young children (<2yrs) for hypoglycemia. Maintain adequate hydration. Pregnancy (Cat.C). Nursing mothers.

Interactions:

Caution with drugs that increase risk of fluid/electrolyte abnormalities, arrhythmias or QT prolongation. Drugs that may lower the seizure threshold (eg, tricyclic antidepressants), alcohol or benzodiazepine withdrawal, known or suspected hyponatremia: may increase risk of seizures. Concomitant diuretics, ACE inhibitors, ARBs, NSAIDs; may affect renal function. Avoid concomitant stimulant laxatives (eg, bisacodyl, sodium picosulfate). Oral drugs administered within 1hr of start of Nulytely may not be absorbed.

Pharmacological Class:

Osmotic laxative.

Adverse Reactions:

Nausea, abdominal fullness and bloating, cramps, vomiting, anal irritation; seizures, arrhythmias, mucosal ulcerations and ischemic colitis. Children: also dehydration or hypokalemia.

How Supplied:

Disposable jug (4L)—1

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