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NORVASC
Angina
Hypertension
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Drug Name:

NORVASC Rx

Generic Name and Formulations:
Amlodipine (as besylate) 2.5mg, 5mg, 10mg; tabs.

Company:
Pfizer Inc.

Therapeutic Use:

Indications for NORVASC:

Vasospastic and chronic stable angina.

Adult:

10mg once daily. Elderly or hepatic impairment: 5mg once daily.

Children:

Not recommended.

Warnings/Precautions:

Severe obstructive coronary disease. Severe aortic stenosis. CHF. Hepatic dysfunction. Pregnancy. Nursing mothers.

Interactions:

May be potentiated by CYP3A inhibitors; monitor and may need to adjust dose. Concomitant CYP3A inducers; monitor BP. Concomitant sildenafil; monitor for hypotension. Concomitant simvastatin: limit simvastatin dose to 20mg/day. May potentiate cyclosporine or tacrolimus; monitor levels and adjust dose.

Pharmacological Class:

Calcium channel blocker (CCB) (dihydropyridine).

Adverse Reactions:

Edema, fatigue, palpitations, dizziness, nausea, flushing, abdominal pain, drowsiness.

How Supplied:

Tabs 2.5mg, 10mg—90; 5mg—90, 300

Indications for NORVASC:

Hypertension.

Adult:

5mg daily. Adjust at 7–14 day intervals; usual max 10mg daily. Small, fragile, elderly, hepatic impaired, patients on other antihypertensives: 2.5mg daily.

Children:

<6yrs: not established. 6–17yrs: 2.5–5mg daily.

Warnings/Precautions:

Severe obstructive coronary disease. Severe aortic stenosis. CHF. Hepatic dysfunction. Pregnancy. Nursing mothers.

Interactions:

May be potentiated by CYP3A inhibitors; monitor and may need to adjust dose. Concomitant CYP3A inducers; monitor BP. Concomitant sildenafil; monitor for hypotension. Concomitant simvastatin: limit simvastatin dose to 20mg/day. May potentiate cyclosporine or tacrolimus; monitor levels and adjust dose.

Pharmacological Class:

Calcium channel blocker (CCB) (dihydropyridine).

Adverse Reactions:

Edema, fatigue, palpitations, dizziness, nausea, flushing, abdominal pain, drowsiness.

How Supplied:

Tabs 2.5mg, 10mg—90; 5mg—90, 300

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