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NITROSTAT
Angina
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Drug Name:

NITROSTAT Rx

Generic Name and Formulations:
Nitroglycerin 0.3mg, 0.4mg, 0.6mg; sublingual tabs.

Company:
Pfizer Inc.

Therapeutic Use:

Indications for NITROSTAT:

Acute relief of angina attack. Acute prophylaxis of angina pectoris.

Adult:

Treatment: 1 tab sublingually or in buccal pouch at onset, may repeat in 5 mins; max 3 tabs in 15 mins. Prophylaxis: 5–10 mins before activity.

Children:

Not established.

Contraindications:

Early MI. Severe anemia. Increased intracranial pressure. Concomitant PDE-5 inhibitors (eg, sildenafil, tadalafil, vardenafil), soluble guanylate cyclase stimulator (eg, riociguat).

Warnings/Precautions:

Acute MI, CHF: monitor. Hypotensive or volume depleted. Hypertrophic cardiomyopathy. Avoid abrupt cessation. Discontinue if blurred vision or dry mouth occurs. Use lowest effective dose. Elderly. Pregnancy (Cat.B). Nursing mothers.

Interactions:

See Contraindications. Hypotension potentiated by PDE-5 inhibitors, calcium channel blockers, riociguat, alcohol, aspirin. May antagonize alteplase, heparin. Drugs that cause dry mouth (eg, tricyclics, anticholinergics) may interfere with sublingual dissolution. Avoid ergotamine and related drugs. Tolerance to other forms of nitrates may blunt effects. May interfere with cholesterol tests.

Pharmacological Class:

Nitrate.

Adverse Reactions:

Headache, vertigo, weakness, palpitation, orthostatic hypotension, tachycardia, syncope, flushing, rash, exfoliative dermatitis.

How Supplied:

Tabs 0.4mg—4 x 25, 100; 0.3mg, 0.6mg—100

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