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NITROMIST
Angina
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Drug Name:

NITROMIST Rx

Generic Name and Formulations:
Nitroglycerin 0.4mg/actuation; lingual aerosol spray.

Company:
Mist Pharmaceuticals, LLC

Therapeutic Use:

Indications for NITROMIST:

Acute attacks and prophylaxis of angina.

Adult:

1–2 sprays at onset of attack, on or under tongue while sitting; may repeat every 5 minutes as needed; max 3 sprays/15 minutes. May use prophylactically 5–10 minutes before exertion. Do not inhale spray. Do not rinse mouth for 5–10 minutes after use.

Children:

Not established.

Contraindications:

Concomitant PDE5 inhibitors (eg, sildenafil, vardenafil, tadalafil), riociguat. Severe anemia. Increased intracranial pressure.

Warnings/Precautions:

Volume depletion. Hypotension. Acute MI. CHF. Hypertrophic cardiomyopathy. Monitor for tolerance. Product is flammable. Elderly. Pregnancy (Cat.C). Nursing mothers.

Interactions:

See Contraindications. Hypotension potentiated with PDE5 inhibitors, riociguat, antihypertensives, β-blockers, calcium channel blockers, alcohol. May be potentiated by aspirin. Nitroglycerin (IV) may antagonize t-PA, heparin (monitor APTT). Avoid concomitant ergotamine and related drugs. Do not use epinephrine to treat hypotension from nitrate overdose.

Pharmacological Class:

Nitrate.

Adverse Reactions:

Headache (may be severe), flushing, rash, hypotension, syncope.

How Supplied:

Bottles—4.1g (90 metered sprays), 8.5g (230 metered sprays)

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