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NITRO-DUR
Angina
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Drug Name:

NITRO-DUR Rx

Generic Name and Formulations:
Nitroglycerin 0.1mg/hr, 0.2mg/hr, 0.3mg/hr, 0.4mg/hr, 0.6mg/hr, 0.8mg/hr; transdermal patches.

Company:
Merck & Co., Inc.

Therapeutic Use:

Indications for NITRO-DUR:

Prophylaxis of angina. Not for acute attacks.

Adult:

Initially one 0.2–0.4mg/hr patch for 12–14hr/day. Remove patch for 10–12hrs/day.

Children:

Not established.

Contraindications:

Concomitant PDE-5 inhibitors (eg, sildenafil, tadalafil, vardenafil), riociguat.

Warnings/Precautions:

Acute MI. Volume depletion. Hypotension. Heart failure. Hypertrophic cardiomyopathy. Reduce dose if hypotension occurs. Remove before defibrillation or cardioversion. Elderly. Pregnancy (Cat.C). Nursing mothers.

Interactions:

See Contraindications. Severe hypotension with PDE-5 inhibitors, riociguat. Hypotension potentiated with alcohol, other vasodilators, calcium channel blockers.

Pharmacological Class:

Nitrate.

Adverse Reactions:

Headache, increased angina, lightheadedness, syncope, orthostatic hypotension, tachycardia, rash.

How Supplied:

Patch—30

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