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NILANDRON
Prostate and other male cancers
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Drug Name:

NILANDRON Rx

Generic Name and Formulations:
Nilutamide 150mg; tabs.

Company:
Covis Pharmaceuticals, Inc.

Therapeutic Use:

Indications for NILANDRON:

Metastatic prostate cancer (Stage D2), as an adjunct to surgical castration.

Adult:

300mg once daily for 30 days then 150mg once daily, starting day of or day after surgical castration.

Children:

Not applicable.

Contraindications:

Severe hepatic impairment or respiratory insufficiency.

Warnings/Precautions:

Obtain baseline liver and pulmonary function tests and chest X-ray. Monitor for interstitial pneumonitis; discontinue if occurs. Monitor liver function for first 4 months then periodically; discontinue if ALT > 2xULN or jaundice occurs. May discolor urine or sclera. Pregnancy (Cat.C): not for use in women. Nursing mothers.

Interactions:

Monitor drugs metabolized by CYP450 (eg, Vit. K antagonists, theophylline, phenytoin); may need to adjust dose. May cause alcohol intolerance.

Pharmacological Class:

Antiandrogen.

Adverse Reactions:

Hot flushes, impaired night vision, GI upset, increased liver enzymes, constipation, dizziness, abnormal vision, hypertension, hepatitis, interstitial pneumonitis.

How Supplied:

Tabs—30

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