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Nicardipine
Angina
Hypertension
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Drug Name:

Nicardipine Rx

Generic Name and Formulations:
Nicardipine HCl 20mg, 30mg; caps.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Nicardipine:

Chronic stable angina.

Adult:

Initially 20mg 3 times daily; adjust at intervals of at least 3 days; max 120mg daily. Severe hepatic impairment: initially 20mg twice daily. Renal insufficiency: 20mg 3 times daily and titrate carefully.

Children:

<18yrs: not recommended.

Contraindications:

Advanced aortic stenosis.

Warnings/Precautions:

Cardiac failure. Acute cerebral infarction or hemorrhage. Hepatic or renal impairment. Measure blood pressure 1–2 hrs and 8 hrs after dosing. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Potentiated by cimetidine. Increases serum levels of cyclosporine, tacrolimus; monitor and adjust its dose. Possibly potentiates digoxin; monitor.

Pharmacological Class:

Calcium channel blocker (CCB) (dihydropyridine).

Adverse Reactions:

Increased angina, hypotension, flushing, headache, pedal edema, asthenia, dizziness, tachycardia, somnolence, GI upset, insomnia.

Note:

Formerly known under the brand name Cardene.

How Supplied:

Contact supplier.

Indications for Nicardipine:

Hypertension.

Adult:

Initially 20mg 3 times daily; adjust at intervals of at least 3 days; max 120mg daily. Severe hepatic impairment: initially 20mg twice daily.

Children:

<18yrs: not recommended.

Contraindications:

Advanced aortic stenosis.

Warnings/Precautions:

Cardiac failure. Angina. Acute cerebral infarction or hemorrhage. Hepatic or renal impairment. Pheochromocytoma. For caps: measure blood pressure (BP) 1–2 hrs and 8 hrs after dosing. For IV: monitor BP before and during infusion; avoid rapid or excessive reductions; switch to oral form when possible. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Potentiated by cimetidine. Increases serum levels of cyclosporine, tacrolimus; monitor and adjust its dose. Possibly potentiates digoxin; monitor.

See Also:

CARDENE IV

CARDENE IV PREMIXED

Pharmacological Class:

Calcium channel blocker (CCB) (dihydropyridine).

Adverse Reactions:

Increased angina, flushing (caps), headache, pedal edema, asthenia, dizziness, somnolence (caps), tachycardia, GI upset, sweating; ECG abnormalities, orthostatic hypotension, ventricular extrasystoles, local reactions (inj).

Note:

Formerly known under the brand name Cardene.

How Supplied:

Caps 20mg, 30mg—contact supplier; IV (10mL amps)—10; Premixed—200mL

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