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Improved tyrosine kinase inhibitor (TKI) selectively activates in tumor tissue, minimizing side effects in patients

A new strategy developed by an interdisciplinary team of researchers aims to reduce the side effects connected to use of tyrosine kinase inhibitors (TKIs).

Prior cancer exclusion criteria may stymie potential of lung cancer clinical trials

A history of prior cancer can exclude many individuals from participation in clinical trails related to lung cancer, even when the prior cancer is unlikely to interfere with treatment outcomes.

Better adherence to guidelines for safe handling of antineoplastic drugs is needed

Recommended safe handling practices for workers who administer antineoplastic drugs in health care settings are not always followed, according to a new study.

Unplanned hospitalizations among gastrointestinal cancer patients common

Unplanned hospitalizations among gastrointestinal cancer patients common

Among elderly patients with gastrointestinal cancer, unplanned hospitalizations are common, according to online research.

Immunotherapy added to radiotherapy may help overcome resistance to treatments

Coupling immunotherapy to radiotherapy treatment could help prevent cancers from becoming resistant to treatment, according to a new study.

Companion diagnostic test improves detection of BRCA mutations in patients with ovarian cancer

The Tumor BRACAnalysis CDx companion diagnostic test boosted the detection of cancer-causing BRCA1/2 mutations in women with ovarian cancer by over 40 percent.

Landmark Medicare law had little impact on reducing chemotherapy cost

Legislation passed in 2003 intended to slow the spiraling costs of drugs paid for by the federal government to treat Medicare patients has not proved to be a success.

70-Gene signature not likely to be cost-effective for breast cancer

70-Gene signature not likely to be cost-effective for breast cancer

Findings in comparative economic analysis of patients with node-negative breast cancer showed the 70-gene signature is unlikely to be cost-effective for guiding adjuvant chemotherapy decision making.

Follow-up colonoscopies too frequent and overused by endoscopists

A retrospective study has uncovered an overuse of colonoscopies for colorectal cancer screening and surveillance.

Current therapy for hypothyroidism endorsed by new guidelines

A recent review has found insufficient consistent data exist to recommend a change in use of levothyroxine as the only drug needed to treat hypothyroidism.

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Companion diagnostic test improves detection of BRCA mutations in patients with ovarian cancer

The Tumor BRACAnalysis CDx companion diagnostic test boosted the detection of cancer-causing BRCA1/2 mutations in women with ovarian cancer by over 40 percent.

Gigapixel camera provides resolution and whole-body imaging for taking a "skin cancer selfie"

A gigapixel camera that takes high-resolution snapshots of the entire body could prove to be a new tool for whole-body skin cancer screening.

Outcomes in nonsquamous lung cancer comparable with docetaxel or pemetrexed

The first direct comparison of treating nonsquamous lung cancer with either pemetrexed or docetaxel in addition to cisplatin has shown that the two combinations achieve similar progression-free survival.

Pertuzumab adds survival benefit for HER2-positive breast cancer

Patients with HER2-positive breast cancer that has metastasized demonstrate longer survival outcomes if treated with a combination of pertuzumab, trastuzumab, and chemotherapy.

IMPRESS trial fails to find benefit from more tyrosine kinase inhibitor (TKI) treatment after resistance develops

Patients with lung cancer that have developed resistance to the drug gefitinib experience no statistically significant improvement in progression-free survival when continued use of the drug with chemotherapy is utilized.

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