News

Variability in breast cancer not a barrier for predictive testing

Breast cancer has variability from the different cell types with different patterns of gene expression in breast cancer, but a new study found that that variability should not be a barrier to using gene expression tests to help tailor cancer treatments to individual patients. These findings were presented at the 5th IMPAKT Breast Cancer Conference.

IMRT offers no significant benefit over CRT following prostatectomy

IMRT offers no significant benefit over CRT following prostatectomy

No significant difference in morbidity, cancer control for men treated post-prostatectomy using Intensity-modulated radiotherapy (IMRT) over conformal radiotherapy (CRT).

NLST: Low-dose helical CT preferable for early lung cancer detection

NLST: Low-dose helical CT preferable for early lung cancer detection

Initial results confirm more positive screening results, diagnostic procedures, cancer ID'd with CT versus standard chest X-rays.

Late recurrence in estrogen-positive breast cancer predicted by genetic and clinical factors

Among women with estrogen-receptor positive breast cancer, late recurrence was best predicted by the clinical treatment score. Significant prognostic value was added by the PAM50 risk of recurrence score and by the Breast Cancer Index score, according to a study comparing five scores that was presented at the 5th IMPAKT Breast Cancer Conference in Brussels, Belgium.

Social ties improve physical symptoms after breast cancer diagnosis

Women with breast cancer who had the strongest social relationships were likeliest to report fewer symptoms and the best overall quality of life.

Everolimus overcomes trastuzumab resistance in HER2+ early breast cancer

Some patients with early breast cancer had a benefit in clinical response rate when everolimus was added to trastuzumab treatment, though the benefit was statistically nonsignificant. These puzzling results suggested that this benefit was independent of the molecular pathways that could be expected to be involved.

Basal-cell carcinoma targeted by new deoxyribozyme drug

A new class of drugs targeting the genetic material of skin cancer has been successfully tested in humans for the first time. This opens the way to new treatments for a range of conditions from skin cancers to eye diseases.

FDA wants warning labels on tanning devices

The FDA is proposing that indoor tanning beds and booths carry labels that warn minors not to use these products.

Sleep problems may increase risk for prostate cancer

Men who reported sleep problems, including difficulty falling asleep and staying asleep, had up to a twofold increased risk for prostate cancer, according to recently published data.

Prostate cancer comorbidities increase other-cause death risk for men

Prostate cancer comorbidities increase other-cause death risk for men

For older men with nonmetastatic prostate cancer, comorbidities increase risk of other-cause death mortality.

Conference Coverage

Rigosertib well tolerated in patients with advanced solid tumors

Orally administered rigosertib was found to be well-tolerated in patients with advanced solid tumors in a phase 1 trial. Rigosertib is a dual kinase inhibitor, and this trial is the first to study its orally administered form in solid tumors.

Quantifying heterogeneity in breast cancer

Later-stage breast cancers tend to have more mutations and are more heterogeneous than early-stage cancers. Now, new findings demonstrate that heterogeneity is prevalent even within legions of DCIS.

New combination of two existing drugs shows promise for resistant lung cancer

A new chemotherapy regimen appears to produce minimal side effects in patients with lung cancer that has not responded to previous therapy, paving the way for additional research to determine if the new regimen also helps shrink tumors.

Biomarker may help identify neuroblastomas vulnerable to a novel class of drugs

An irregularity within many neuroblastoma cells may indicate whether a neuroblastoma tumor is vulnerable to a new class of anti-cancer drugs known as BET bromodomain inhibitors.

Gene variations that predict chemotherapy side effects identified

Seemingly benign differences in genetic code from one person to the next could influence who develops side effects to chemotherapy. A new study identified gene variations that can predispose people to chemotherapy-induced peripheral neuropathy.

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