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NEURONTIN TABLETS
Nonnarcotic analgesics
Seizure disorders
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Drug Name:

NEURONTIN TABLETS Rx

Generic Name and Formulations:
Gabapentin 600mg, 800mg; scored.

Company:
Pfizer Inc.

Therapeutic Use:

Indications for NEURONTIN TABLETS:

Postherpetic neuralgia.

Adult:

300mg once on day 1, twice daily on day 2, and 3 times daily on day 3; may titrate up to usual max 1.8g/day in 3 divided doses (doses up to 3.6g/day have been used without added benefit). Renal dysfunction: CrCl 30–59mL/min: 400–1400mg/day in 2 divided doses; CrCl 15–29mL/min: 200–700mg once daily; CrCl ≤15mL/min: 100–300mg once daily (see full labeling); hemodialysis: 125–350mg after session.

Children:

Not established.

Warnings/Precautions:

Renal dysfunction. Suicidal behavior and ideation (monitor). Monitor for DRESS/multiorgan hypersensitivity, anaphylaxis, angioedema; discontinue if occurs. Avoid abrupt cessation. Elderly. Pregnancy (Cat.C). Nursing mothers.

Interactions:

Potentiates CNS depression with alcohol, morphine, other CNS depressants. Give 2 hrs after antacids. May antagonize hydrocodone. May interfere with some urine protein tests (eg, Multistix-SG).

See Also:

NEURONTIN CAPSULES

NEURONTIN ORAL SOLN

Adverse Reactions:

Dizziness, somnolence, peripheral edema, nausea, ataxia, amblyopia, thought disorder, abnormal gait, incoordination.

How Supplied:

Caps, tabs—100; Soln—470mL

Indications for NEURONTIN TABLETS:

Adjunct in partial seizures.

Adult:

Add or remove other AEDs over at least 1 week. Initially 300mg three times daily. Usual range: 900–1800mg/day in 3 divided doses; max 2.4g/day (up to 3.6g/day has been used short-term; see full labeling); max 12 hrs between doses. Renal dysfunction: CrCl 30–59mL/min: 400–1400mg/day in 2 divided doses; CrCl 15–29mL/min: 200–700mg once daily; CrCl ≤15mL/min: 100–300mg once daily (see full labeling); hemodialysis: 125–350mg after session.

Children:

<3yrs: not established. Give in 3 divided doses; max 12 hrs between doses; titrate over 3 days. 3–11yrs: initially 10–15mg/kg per day. 3–4yrs: titrate to 40mg/kg per day. ≥5yrs: titrate to 25–35mg/kg per day. Max 50mg/kg per day. Renal impairment: not studied.

Warnings/Precautions:

Renal dysfunction. Suicidal behavior and ideation (monitor). Monitor for DRESS/multiorgan hypersensitivity, anaphylaxis, angioedema; discontinue if occurs. Avoid abrupt cessation. Elderly. Pregnancy (Cat.C). Nursing mothers.

Interactions:

Potentiates CNS depression with alcohol, morphine, other CNS depressants. Give 2 hrs after antacids. May antagonize hydrocodone. May interfere with some urine protein tests (eg, Multistix-SG).

See Also:

NEURONTIN CAPSULES

NEURONTIN ORAL SOLN

Adverse Reactions:

Somnolence, dizziness, ataxia, fatigue, nystagmus; diplopia, amblyopia, tremor, dysarthria, amnesia, back pain; children also: viral infection, fever, nausea, vomiting, emotional lability, thought disorder, hyperkinesia, hostility.

How Supplied:

Caps, tabs—100; Soln—470mL

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