Generic Name and Formulations:
Pentobarbital sodium 50mg/mL; soln for IM or IV inj; contains alcohol.
Indications for NEMBUTAL:
Short-term (≤ 2 weeks) treatment of insomnia when oral route is not feasible.
IM: 150mg–200mg (max 5mL/inj) as a single deep IM inj. IV: Inject slowly (max 50mg/min). ≥70kg: initially 100mg; observe and monitor vital signs at least 1 minute, then may increase as needed in small increments to usual max 500mg. Elderly, debilitated, renal or hepatic impairment: reduce dose.
IM: 2–6mg/kg as a single deep IM inj; max 100mg. IV: inject slowly; reduce adult dose proportionally (see literature).
Prehepatic coma: not recommended. Avoid abrupt cessation. Acute or chronic pain. Depression. Suicidal tendencies. Drug abuser. Hepatic or renal impairment. Monitor BP, respiration, cardiac function. Avoid extravasation. Write ℞ for smallest practical amount. Elderly. Debilitated. Labor & delivery. Pregnancy (Cat.D). Nursing mothers.
Potentiated by MAOIs, valproic acid, sodium valproate (monitor). CNS depression potentiated with alcohol, other CNS depressants. Antagonizes anticoagulants, corticosteroids, other steroid hormones (eg, oral contraceptives), doxycycline. May interfere with griseofulvin absorption. Variable effects with phenytoin (monitor).
Somnolence, respiratory depression, CNS effects, bradycardia, hypotension, syncope, GI upset, headache, inj site reactions, paradoxical excitement.
Multi-dose vials (20mL, 50mL)—1
Sign Up for Free e-newsletters
- CHEMO-SUPPORT: A Nursing Intervention to Relieve Chemotherapy Symptom Burden
- A Witness to Letting Go: Nursing Care at the End of Life
- Sexual Quality of Life Decreased During, After Chemotherapy for Digestive Cancers
- Androgen-Deprivation Therapy for Prostate Cancer May Cause Nocturia, Sleep Disturbance
- Approach and Management of Checkpoint Inhibitor-related Immune Hepatitis
- Various Aspects of Palliative Care Focus Associated With Different Outcomes In Cancer
- Cost vs Benefits: The Controversy Over Proton Beam Radiotherapy
- Patient Expectations at Odds With Actual Outcomes for Radiotherapy in Breast Cancer
- Patients Desire More Online Tools and Access
- Managing Chemo Brain in Pediatric Survivors of Childhood Cancer
- Modified XELIRI Noninferior to FOLFIRI for OS in Metastatic Colorectal Cancer
- Nabilone Improves Cancer-Associated Anorexia in Lung Cancer
- Direct-to-Consumer Genetic Test for Select BRCA Mutations Gets FDA Nod
- Patients With Head and Neck Cancer Have Greater Chance of Being Prescribed Opioids
- Medical Terms in Patient Education: Using the Confusing to Explain the Complicated
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
|Head and Neck Cancer||Regimens||Drugs|